Failure criterion of collagen fiber: Viscoelastic behavior simulated by using load control data

Wang, Jaw‐Lin; Parnianpour, Mohamad; Shirazi-Adl, A.; Engin, Ali Erkan

doi:10.1016/s0167-8442(97)00002-5

Cited by 41 publications

(27 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The failure strain of collagen is known to be strain-rate dependent, 45 but we did not account for this behavior. However, this should not influence the finding that excessive shear strains along the collagen fibrils and excessive fibril strain are both associated with different sites of damage.…”

Section: Discussionmentioning

confidence: 99%

Causes of mechanically induced collagen damage in articular cartilage

Wilson

Burken

Donkelaar

et al. 2005

Journal Orthopaedic Research

121

126

View full text Add to dashboard Cite

Osteoarthritis (OA) is a multifactorial disease, associated with articular cartilage degeneration and eventually joint destruction. The phases of the disease have been described in detail, and mechanical factors play an important role in the initiation of OA, but many questions remain about its etiology. Swelling of cartilage, one of the earliest signs of damage, is proportional to the amount of collagen damage. This strongly suggests that damage to the collagen network is an early event in cartilage degeneration. The goal of this study was to determine the mechanical cause of early collagen damage in articular cartilage after mechanical overloading. Both the shear strain along the fibrils and the maximum fibril strains were evaluated as possible candidates for causing collagen damage. This evaluation was done by comparing the locations of maximum shear and tensile strains with the locations of initial collagen damage after mechanical overloading in bovine explants as found using antibodies directed against denatured type II collagen (Col2-3/4M). Collagen damage could be initiated by excessive shear strains along the collagen fibrils, and by excessive fibrils strains. The locations of collagen damage after mechanical overloading were highly dependent on the cartilage thickness, with thinner cartilage being more susceptible to damage than thicker samples. ß

show abstract

Section: Discussionmentioning

confidence: 99%

Causes of mechanically induced collagen damage in articular cartilage

Wilson

Burken

Donkelaar

et al. 2005

Journal Orthopaedic Research

121

126

View full text Add to dashboard Cite

show abstract

“…Collagen fibres also show time-and history-dependent stress-strain behaviour, similar to tendon on the tissue scale. With the assumption of fibres being independent of each other, collagen fibres have recently been characterized by linear elastic, bilinear elastic, linear viscoelastic and QLV formulations under tension, in studies which both consider the interfibrillar matrix or neglect it [57,80,81,[88][89][90]. The various fibril PDFs (described above) can be incorporated into these formulations to examine the role of collagen fibres in tendon behaviour.…”

Section: Contribution Of Collagen Fibril To Tendon Mechanicsmentioning

confidence: 99%

Modelling approaches for evaluating multiscale tendon mechanics

Fang

Lake

2016

Interface Focus.

View full text Add to dashboard Cite

Tendon exhibits anisotropic, inhomogeneous and viscoelastic mechanical properties that are determined by its complicated hierarchical structure and varying amounts/organization of different tissue constituents. Although extensive research has been conducted to use modelling approaches to interpret tendon structure–function relationships in combination with experimental data, many issues remain unclear (i.e. the role of minor components such as decorin, aggrecan and elastin), and the integration of mechanical analysis across different length scales has not been well applied to explore stress or strain transfer from macro- to microscale. This review outlines mathematical and computational models that have been used to understand tendon mechanics at different scales of the hierarchical organization. Model representations at the molecular, fibril and tissue levels are discussed, including formulations that follow phenomenological and microstructural approaches (which include evaluations of crimp, helical structure and the interaction between collagen fibrils and proteoglycans). Multiscale modelling approaches incorporating tendon features are suggested to be an advantageous methodology to understand further the physiological mechanical response of tendon and corresponding adaptation of properties owing to unique in vivo loading environments.

show abstract

“…Collagen fibers have been previously modeled as linear elastic (Diamant et al 1972;Kastelic et al 1980;Stouffer et al 1985), bilinear elastic (Belkoff and Haut 1992;Hurschler et al 1997;Kwan and Woo 1989), and linear viscoelastic (Johnson et al 1996;Wang et al 1997;Wilson et al 2004). To represent the nonlinear effects of collagen recruitment in the current model, collagen fibers were simulated using axially oriented nonlinear spring elements attached at the nodes of the matrix elements, similar to the model of Wilson et al (1997).…”

Section: Collagen Fibersmentioning

confidence: 99%

A finite element model predicts the mechanotransduction response of tendon cells to cyclic tensile loading

Lavagnino

Arnoczky

Kepich

et al. 2007

Biomech Model Mechanobiol

View full text Add to dashboard Cite

The importance of fluid-flow-induced shear stress and matrix-induced cell deformation in transmitting the global tendon load into a cellular mechanotransduction response is yet to be determined. A multiscale computational tendon model composed of both matrix and fluid phases was created to examine how global tendon loading may affect fluid-flow-induced shear stresses and membrane strains at the cellular level. The model was then used to develop a quantitative experiment to help understand the roles of membrane strains and fluid-induced shear stresses on the biological response of individual cells. The model was able to predict the global response of tendon to applied strain (stress, fluid exudation), as well as the associated cellular response of increased fluid-flow-induced shear stress with strain rate and matrix-induced cell deformation with strain amplitude. The model analysis, combined with the experimental results, demonstrated that both strain rate and strain amplitude are able to independently alter rat interstitial collagenase gene expression through increases in fluid-flow-induced shear stress and matrix-induced cell deformation, respectively.

show abstract

Failure criterion of collagen fiber: Viscoelastic behavior simulated by using load control data

Cited by 41 publications

References 45 publications

Causes of mechanically induced collagen damage in articular cartilage

Causes of mechanically induced collagen damage in articular cartilage

Modelling approaches for evaluating multiscale tendon mechanics

A finite element model predicts the mechanotransduction response of tendon cells to cyclic tensile loading

Contact Info

Product

Resources

About