Under pressurized thermal shock (PTS), once crack initiation occurs in a reactor pressure vessel (RPV), the stress concentration around the crack tips may result in local instability and crack propagation. The temperature‐dependent material properties are introduced into the finite element analysis model. According to the response of the transient temperature field and stress field near the crack tip region, the influence of PTS on the carrying capacity of the structure is demonstrated. Also, the process of crack initiation and propagation is simulated by using the extended finite element method (XFEM). The results show that the crack of mode I is easy to be initiated on the nozzle in the initial high temperature and high pressure working state. The effect of cladding on the RPV integrity is enhanced with the increase of crack size, and it mainly depends on the crack length. During the PTS transient, a discontinuity of stress exists near the cladding‐base interface, and the cladding bears more loading than the base of the same size. As the unloading of the internal pressure, the stress does not decline due to the strong thermal shock. In the late stage of the PTS process, the internal pressure caused by repressurization poses a challenge to the strength of the structure. With the decrease of the base wall thickness, the allowable repressure value also gradually decreases. However, the increase of the base wall thickness causes the rise of thermal stress, and the allowable repressure load is not significantly improved.