Failing Factors Associated With Osseointegrated Dental Implant Loss

Abstract

The results obtained in this study suggest that host factors can be contributing to the failure of implants.

Outcome after pelvic sarcoma resection and reconstruction with a modular hemipelvic prostheses

“…We used the ISOLS system [14] at the latest follow-up and the score was 19.5. It is critical that osseointegration is achieved after the surgery because failure in the osseointegration process is a significant cause of implant loss [28]. Osseointegration implies a firm, direct and lasting connection between vital bone and the titanium implants [3,26].…”

“…It was definded by Brånemark that an implant is regarded as osseointegrated when there is no progressive relative movement between the implant and the bone with which it has direct contact [8,9]. Montes considered that living and functional bone tissue formation around the implants results in osseointegration [25,28]. Success of osseointegration depends on certain factors [33], such as implant biomaterial and superficial properties (topography and surface roughness) [4,10,11,18,19,22], appropriate bone quantity and quality [15], systemic factors and no surgical complications, such as bone overheating and contamination [4,24], and peri-implantitis [32,36].…”

The Current Knowledge of Genetic Susceptibility Influencing Dental Implant Outcomes

“…Late failures have been related to peri-implantitis (Rosenberg et al, 2004), and occlusal overload (Misch et al, 2004). Although many studies have provided an important contribution to the understanding of the implant failure process, in some situations, clinical factors alone do not explain why some present implant loss (Deas et al, 2002;Montes et al, 2007). The goal that should be achieved by modern implantology research is developing tools able to predict the patient biological response to treatment before implant surgery intervention.…”

“…The knowledge that implant loss i) is not totally explained by clinical conditions and ii) tends to cluster in subsets of individuals (Montes et al, 2007;Weyant and Burt, 1993) may indicate that specific host response characteristics, that disturb the osseointegration process, are influenced by genetic factors (Alvim-Pereira et al, 2008a). Gene polymorphisms are a mechanism by which individuals may exhibit variations in DNA sequence.…”

“…In this approach the physiology and involved metabolic pathways of healing and osseointegration process are the basis to search for candidate genes underlying host susceptibility to implant failure. But, a number of biologic mechanisms is involved in the osseointegration complex process, some of which have not yet been identified (Mengatto et al 2011;Montes et al, 2007). Although some similarities between osseointegration and tooth extraction socket were seen, different pathways of transcription and growth factors, extracellular matrix molecules, and chemokines were proposed (Lin et al, 2010).…”