Fahr’s Syndrome presenting with epileptic seizure, two case reports

Ongun, Nedim; Değirmenci, Eylem; Erdoǧan, Çağdaş

doi:10.14744/nci.2015.47966

Cited by 4 publications

(5 citation statements)

References 11 publications

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“…It can be seizures, pyramidal syndrome, akinetic hypertonic syndrome, cerebellar syndrome generally discreet, urinary problems, choreic athetosic movements, dysarthria or mumbling speech. However, seizures are rarely reported as revealing symptoms [10]. Cranial nerves involvement and bouts of benign intracranial hypertension are rare, while cases without neurological symptoms have been reported [1,7].…”

Section: Discussionmentioning

confidence: 99%

Fahr's syndrome with hyperparathyroidism revealed by seizures and proximal weakness

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Fahr's syndrome with hyperparathyroidism revealed by seizures and proximal weakness

et al. 2019

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“…Concerning the etiopathogenic mechanism, the epileptic seizures may be caused by hypocalcemia due to primary hypoparathyroidism (explained by an increase in neuronal excitability induced by the drop in extracellular calcium concentration); however, another hypothesis is taken into consideration: the dysfunction of the cortico-basal connections and their interhemispheric relationships (13,14).…”

Section: Resultsmentioning

confidence: 99%

Epileptic Seizures as te First Manifestation of Fahr’s Syndrome

et al. 2020

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Introduction.Hypoparathyroidism is a rare endocrine disorder, leading to complications affecting the kidneys, the eyes, the cerebrum (Fahr's syndrome, epilepsy, parkinsonism, cognitive impairment), and the heart.Case report. We present the case of a 24-year old male that presented to our clinic for generalized tonicclonic seizures increasing in frequency for the last year or so. Furthermore, he was diagnosed with subcapsular cataract of both eyes and had intraocular lens implant surgery 12 years ago. CT scan performed at admission showed calcium deposits on the dentate nuclei, basal ganglia, thalamus, cerebellum and bilateral subcortical fronto-parietal white matter compatible with Fahr's disease. The results of the laboratory tests were normal except for hypocalcemia, hyperphosphoremia and low intact parathormone (iPTH). The patient was diagnosed with primary hypoparathyroidism which led to Fahr's syndrome. The patient was prescribed oral medication including calcium carbonate, calcidiol, magnesium orotate and levetiracetam. The follow-up after three months revealed a seizure free status and normalization of magnesium, calcium, and phosphorus levels.Conclusion. Fahr's syndrome can be a cause of epileptic seizures and should be considered in the clinical approach to an epileptic patient, especially in children, teenagers, and young adults.

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“…Fahr’s syndrome is often first diagnosed when CT imaging reveals bilateral intracerebral calcifications in the cerebral gray matter such as those seen in HY. However, the clinical presentations and age at the time of presentation vary greatly [ 3 ]. While basal ganglia calcifications are common idiopathic findings in older patients, it is more concerning in our patient given her younger age.…”

Section: Discussionmentioning

confidence: 99%

“…Although her EEG did not review any abnormalities, this study is limited by timing. Furthermore, seizures are rarely reported as the presenting symptoms of Fahr’s syndrome [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Fahr’s Syndrome in the Setting of Abnormal Calcium-Phosphate Metabolism and Lupus Nephritis

Haider¹,

Liang²,

Khan³

2022

Cureus

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Fahr's syndrome is a rare neurodegenerative disorder characterized by bilateral calcifications of the basal ganglia and cerebral cortex. These deposits are made of calcium and phosphorus and are thought to be due to abnormalities in calcium-phosphate homeostasis. The clinical manifestation includes extrapyramidal symptoms (e.g., spastic paralysis), generalized or partial seizures, cognitive impairment, and neuropsychiatric symptoms. Here, we discuss a case of a young female with a medical history of systemic lupus erythematosus (SLE) and lupus nephritis who developed generalized seizures and was found to have extensive bilateral calcifications in the basal ganglia and cerebral cortex. Her laboratory workup showed disorganized calcium-phosphorus homeostasis.

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Fahr’s Syndrome presenting with epileptic seizure, two case reports

Cited by 4 publications

References 11 publications

Fahr's syndrome with hyperparathyroidism revealed by seizures and proximal weakness

Fahr's syndrome with hyperparathyroidism revealed by seizures and proximal weakness

Epileptic Seizures as te First Manifestation of Fahr’s Syndrome

Fahr’s Syndrome in the Setting of Abnormal Calcium-Phosphate Metabolism and Lupus Nephritis

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