Faecalibacterium prausnitzii subspecies–level dysbiosis in the human gut microbiome underlying atopic dermatitis

Song, Han; Yoo, Young; Hwang, Junghyun; Na, Yun-Cheol; Kim, Heenam Stanley

doi:10.1016/j.jaci.2015.08.021

Cited by 313 publications

(331 citation statements)

References 56 publications

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“…In addition, the relation between the gut microbiome in inflammatory bowel disease and response to infliximab was also recently highlighted 90. In particular, when considering the reports about the role of the gut‐skin axis that might influence many diseases including the here investigated skin disorders 91, 92, 93.…”

Section: Discussionmentioning

confidence: 83%

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

Kolk

Wall

Balmforth

et al. 2018

Brit J Clinical Pharma

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AimsTo explore the potential of the skin microbiome as biomarker in six dermatological conditions: atopic dermatitis (AD), acne vulgaris (AV), psoriasis vulgaris (PV), hidradenitis suppurativa (HS), seborrhoeic dermatitis/pityriasis capitis (SD/PC) and ulcus cruris (UC).MethodsA systematic literature review was conducted according to the PRISMA guidelines. Two investigators independently reviewed the included studies and ranked the suitability microbiome implementation for early phase clinical studies in an adapted GRADE method.ResultsIn total, 841 papers were identified and after screening of titles and abstracts for eligibility we identified 42 manuscripts that could be included in the review. Eleven studies were included for AD, five for AV, 10 for PV, two for HS, four for SD and 10 for UC. For AD and AV, multiple studies report the relationship between the skin microbiome, disease severity and clinical response to treatment. This is currently lacking for the remaining conditions.ConclusionFor two indications – AD and AV – there is preliminary evidence to support implementation of the skin microbiome as biomarkers in early phase clinical trials. For PV, UC, SD and HS there is insufficient evidence from the literature. More microbiome‐directed prospective studies studying the effect of current treatments on the microbiome with special attention for patient meta‐data, sampling methods and analysis methods are needed to draw more substantial conclusions.

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Section: Discussionmentioning

confidence: 83%

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

Kolk

Wall

Balmforth

et al. 2018

Brit J Clinical Pharma

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“…4 Numerous investigators have shown that changes in the gut microbiota and intestinal inflammation have been associated with the development of allergic diseases. 6,8,13,23 The gut microbiota controls intestinal inflammation, which further modulates the development of the systemic immune system. 8,23 Altered gut microbiota induces epithelial damage resulting in increased intestinal inflammation, altered gut permeability and immunological balance, which affect the development of allergic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…6,8,13,23 The gut microbiota controls intestinal inflammation, which further modulates the development of the systemic immune system. 8,23 Altered gut microbiota induces epithelial damage resulting in increased intestinal inflammation, altered gut permeability and immunological balance, which affect the development of allergic diseases. 8,13,23 The damaged epithelium with increased permeability might allow for the passage of allergens.…”

Section: Discussionmentioning

confidence: 99%

“…8,23 Altered gut microbiota induces epithelial damage resulting in increased intestinal inflammation, altered gut permeability and immunological balance, which affect the development of allergic diseases. 8,13,23 The damaged epithelium with increased permeability might allow for the passage of allergens. 24 Prolonged enhanced permeability and increased exposure to allergens might result in the subsequent development of atopic eczema.…”

Section: Discussionmentioning

confidence: 99%

“…25 Altered gut microbiota and subsequently reduced production in SCFA can be implicated in children with AD. 8 The gut microbiota appears to play an important role in controlling not only gut specific but also distant immune responses.…”

Section: Discussionmentioning

confidence: 99%

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Elevated fecal calprotectin levels are associated with severity of atopic dermatitis in children

Seo

Ahn

et al. 2017

Asian Pac J Allergy Immunol

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Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis

et al. 2018

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IMPORTANCE Oral intake of new probiotic formulations may improve the course of atopic dermatitis (AD) in a young population.OBJECTIVE To determine whether a mixture of oral probiotics is safe and effective in the treatment of AD symptoms and to evaluate its influence on the use of topical steroids in a young population. DESIGN, SETTING, AND PARTICIPANTSA 12-week randomized, double-blind, placebo-controlled intervention trial, from March to June 2016, at the outpatient hospital Centro Dermatológico Estético de Alicante, Alicante, Spain. Observers were blinded to patient groupings. Participants were children aged 4 to 17 years with moderate atopic dermatitis. The groups were stratified and block randomized according to sex, age, and age of onset. Patients were ineligible if they had used systemic immunosuppressive drugs in the previous 3 months or antibiotics in the previous 2 weeks or had a concomitant diagnosis of intestinal bowel disease or signs of bacterial infection.INTERVENTIONS Twelve weeks with a daily capsule containing freeze-dried powder with 10 9 total colony-forming units of the probiotic strains Bifidobacterium lactis CECT 8145, B longum CECT 7347, and Lactobacillus casei CECT 9104 and maltodextrin as a carrier, or placebo (maltodextrin-only capsules).MAIN OUTCOMES AND MEASURES SCORAD index score and days of topical steroid use were analyzed.RESULTS Fifty children (26 [50%] female; mean [SD] age, 9.2 [3.7] years) participated. After 12 weeks of follow-up, the mean reduction in the SCORAD index in the probiotic group was 19.2 points greater than in the control group (mean difference, −19.2; 95% CI, −15.0 to −23.4). In relative terms, we observed a change of −83% (95% CI, −95% to −70%) in the probiotic group and −24% (95% CI, −36% to −11%) in the placebo group (P < .001). We found a significant reduction in the use of topical steroids to treat flares in the probiotic arm (161 of 2084 patient-days [7.7%]) compared with the control arm (220 of 2032 patient-days [10.8%]; odds ratio, 0.63; 95% CI, 0.51 to 0.78). CONCLUSIONS AND RELEVANCEThe mixture of probiotics was effective in reducing SCORAD index and reducing the use of topical steroids in patients with moderate AD. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT02585986

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Faecalibacterium prausnitzii subspecies–level dysbiosis in the human gut microbiome underlying atopic dermatitis

Cited by 313 publications

References 56 publications

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

Elevated fecal calprotectin levels are associated with severity of atopic dermatitis in children

Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis

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