“…It has previously been shown that antibody responses can be seen as early as IFN-␥ responses in Johne's infected animals Lybeck et al 2010;Robinson et al 2008;Waters et al 2003). This can be observed in sheep exposed to Map irrespective of whether the animals are found to have infection at necropsy.…”
“…It has previously been shown that antibody responses can be seen as early as IFN-␥ responses in Johne's infected animals Lybeck et al 2010;Robinson et al 2008;Waters et al 2003). This can be observed in sheep exposed to Map irrespective of whether the animals are found to have infection at necropsy.…”
“…Although this is generally not associated with paratuberculosis in goats, similar findings were described in a recent study of naturally infected goats. 20 Variable findings have been reported concerning the preferential sites of lesions in the intestine of goats with paratuberculosis. Several studies found the jejunum most severely affected, 19,20,36,41 whereas others noted the distal small intestine.…”
Section: Discussionmentioning
confidence: 99%
“…20 Variable findings have been reported concerning the preferential sites of lesions in the intestine of goats with paratuberculosis. Several studies found the jejunum most severely affected, 19,20,36,41 whereas others noted the distal small intestine. 25,40 In our investigation, predominantly JPPs in the proximal and mid-jejunum and the ICVPP were altered in subclinical paratuberculosis.…”
The development of lesions after infection with Mycobacterium avium subsp paratuberculosis (MAP) was examined in an experimental infection model. Goat kids were orally inoculated 10 times with 10 mg bacterial wet mass of MAP (total dose 2.6 × 10(8) colony-forming units). Six to 7 inoculated goats and 3 controls were autopsied 3, 6, 9, and 12 months postinoculation (mpi), lesions were documented, and samples were collected for histology, immunohistochemistry (IHC), and bacterial culture. Twenty-five of the 26 inoculated goats did not develop clinical signs. Macroscopic lesions were detected in 3 of the 7 inoculated goats as soon as 3 mpi. Jejunal Peyer's patches (JPPs) were thickened and had ulcerated surfaces and circumscribed serositis. Characteristic granulomatous infiltrates were seen in all goats in gut-associated lymphoid tissues (GALTs), especially JPPs and lymphoid tissue at the ileocecal valve and in intestinal lymph nodes. Granulomatous intestinal infiltrates not associated with GALT were seen beginning at 6 mpi and with increasing frequency thereafter. Interindividual differences in lesions were most pronounced at 12 mpi, varying from mild focal paucibacillary to severe diffuse multibacillary patterns. Bacterial culture of MAP confirmed the IHC findings but was more sensitive and revealed widespread dissemination at 3 and 12 mpi. Granulomatous arteritis was found in intestinal submucosa of several goats. This may contribute to the spreading of MAP to the intestinal wall and possibly systemically. The different lesions observed during the clinically inapparent period of paratuberculosis are most likely indicators for the later progression of infection and development of clinical disease.
“…Diarrhea is reported in some animals that is intermittent at initial stages but tend to persist in later stages. Reduced ruminal motility is also reported in effected goats (Lybeck et al, 2011) Blood Parameters Lybeck et al, (2011) reported decrease in hematochrit, hemoglobin and albumin levels in effected goats. Almujalli and Al-Ghamdi (2012) reported increase in creatinine, blood urea nitrogen, magnesium, AST and ALT in diseased camels.…”
Section: Clinical Signsmentioning
confidence: 92%
“…In later stages of infection Th2 (humoral) response (Wadhwa et al, 2013) may be present but it doesn't prove sufficient to check infection (Stabel, 2000). Lybeck et al, (2011) reported shedding of MP in feces in effected goats before interferon gamma which usually preceded humoral immune response.…”
Mycobacterium paratuberculosis the subspecies of M. avium, effects wide range of animals including domestic cattle, sheep, goats, buffaloes, camelids and wild ruminants resulting in progressive and chronic enteritis known as Johne's disease (paratuberculosis). Clinically sick animals show emaciation, diarrhea and eventually death but the risk is that mostly they don't show clinical sign still can shed bacteria in feces and milk. Organism spread in the animal body through blood and lymph nodes to multiple internal organs. It is economically very important disease in livestock because effected livestock is recommended to be culled due to high treatment costs. Etiology, host range, immunology, epidemiology, stages/ forms, clinical signs, diagnostic tools and treatment have been discussed with special reference to endemic situations. Strategies to control this disease include improved management practices, testing and culling and vaccination. Modifications in management practices is not an easy job and so is the case with testing and culling; vaccine on the other hand is the simple practice but it is not usually practiced by farmers because lack of knowledge/awareness in herdsmen and availability of vaccine.All copyrights reserved to Nexus® academic publishers
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