2020
DOI: 10.1136/annrheumdis-2019-216471
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Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice

Abstract: ObjectivesEmerging evidence suggests that the microbiome plays an important role in the pathogenesis of osteoarthritis (OA). We aimed to test the two-hit model of OA pathogenesis and potentiation in which one ‘hit’ is provided by an adverse gut microbiome that activates innate immunity; the other ‘hit’ is underlying joint damage.MethodsMedical history, faecal and blood samples were collected from human healthy controls (OA-METS-, n=4), knee OA without metabolic syndrome (OA+METS-, n=7) and knee OA with metabol… Show more

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Cited by 74 publications
(80 citation statements)
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References 68 publications
(65 reference statements)
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“…Fusobacterium were enriched in Pre-RA group of mice compared with HC, while Akkermansia and Staphylococcus were enriched in both Pre-RA and RA groups. Interestingly, Fusobacterium has been implicated in metabolic disorder [33,34], osteoarthritis [35] and Behcet's disease [36]. One of the most well-known pathogenic species within the Fusobacterium genus, Fusobacterium nucleatum, are associated with the occurrence of multiple conditions including colorectal carcinoma [37], IBD [38], and RA [39].…”
Section: Discussionmentioning
confidence: 99%
“…Fusobacterium were enriched in Pre-RA group of mice compared with HC, while Akkermansia and Staphylococcus were enriched in both Pre-RA and RA groups. Interestingly, Fusobacterium has been implicated in metabolic disorder [33,34], osteoarthritis [35] and Behcet's disease [36]. One of the most well-known pathogenic species within the Fusobacterium genus, Fusobacterium nucleatum, are associated with the occurrence of multiple conditions including colorectal carcinoma [37], IBD [38], and RA [39].…”
Section: Discussionmentioning
confidence: 99%
“…Huang et al designed a study to collect fecal samples from human healthy controls, knee OA without metabolic syndrome, and knee OA with metabolic syndrome groups, then transplant pooled samples into germ-free OA mice induced by meniscal/ligamentous injury (MLI). Interestingly, only the microbiota transplantation from the knee OA with metabolic syndrome and MLI resulted in an increase in the severity of OA, which was also consistently associated with elevated inflammatory biomarkers and gut permeability [ 21 ]. These findings support that an adverse microbiome would exacerbate the histopathological severity of OA induced by joint injury in a murine model.…”
Section: Gut Microbiota Modulation As Treatment Of Oamentioning
confidence: 99%
“…The combinative treatments increased the abundance of Bifidobacterium and Roseburia and decreased Clostridium leptum and Akkermansia muciniphila . Huang et al, 2020 [ 21 ] MLI-induced OA germ-free mice model FMT (fecal samples collected from human healthy controls, knee OA without metabolic syndrome and knee OA with metabolic syndrome) 10 weeks OA severity was minimal in GF mice following MLI. Compared with the other groups, transplantation with the knee OA with metabolic syndrome groups, microbiome was associated with higher systemic levels of inflammatory biomarkers, higher gut permeability and worse OA severity.…”
Section: Introductionmentioning
confidence: 99%
“…They transplanted faecal microbiota from healthy and from metabolically compromised human donors into germ-free mice, 2 weeks before articular knee injury. Compared with the other groups, transplantation with the microbiome from metabolically compromised donors was associated with higher mean systemic concentrations of inflammatory biomarkers, higher gut permeability, and worse OA severity [ 72 ].…”
Section: Gut-dysbiosis-derived Inflammatory Mechanismsmentioning
confidence: 99%