Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis

Biskou, Olga; Gardner‐Medwin, Janet; Mackinder, Mary; Bertz, Martin; Clark, Caspar; Svolos, Vaios; Russell, Richard K.; Edwards, Christine; McGrogan, Paraic; Gerasimidis, Konstantinos

doi:10.1097/mpg.0000000000001384

Cited by 17 publications

(16 citation statements)

References 11 publications

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“…Intestinal atrophy seems to be a dominant feature influencing the FC levels in CD patients (15). Here, we detected markedly higher FC levels in the patients that all had villous atrophy (Marsh score 3) while previous reports incorporated children with lower Marsh scores (4,11,15). However, FC was associated with neither the grade of intestinal inflammation nor with the clinical picture of CD in a report by Montalto et al (17).…”

Section: Discussioncontrasting

confidence: 45%

“…In a recent report, children with total villous atrophy showed higher FC levels (13.8 ± 9.3 mg/L) than those with partial atrophy (3.7 ± 1.8 mg/L) (15). Similarly, 17 children newly identified with CD had higher FC levels than healthy children (11). According to the report by Tola et al (16), the mean value of FC was significantly higher in adults with CD than in healthy ones.…”

Section: Discussionmentioning

confidence: 93%

“…As controls, 70 healthy age and sex-matched children were recruited from the same geographical region. The sample size was determined based on the availability of newly diagnosed CD children and the report of Biskou et al (11). The individuals with systemic disorders, family history of intestinal inflammatory disease, and history of taking a gluten-free diet (GFD) were excluded.…”

Section: Study Populationmentioning

confidence: 99%

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A Survey of Fecal Calprotectin in Children with Newly Diagnosed Celiac Disease with Villous Atrophy

et al. 2019

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Background: Fecal calprotectin (FC) has been used as a diagnostic marker in intestinal inflammatory conditions. Objectives: As a few studies have been dedicated to assess the role of FC in coeliac disease (CD), the current study aimed to address this issue. Methods: This study included 70 newly diagnosed CD (Marsh score 3) and 70 healthy children. The study was performed at the pediatric ward of Amir-Al-Momenin Hospital in Zabol city, the southeast of Iran, during June 2016-September 2017. The FC level was determined using a specific ELISA kit. Results: Women constituted 64.3% (45/70) and 55.1% (38/70) of CD and healthy children, respectively (P = 0.1). Three was no significant difference in the mean age between children with CD (6.3 ± 3.4) and without CD (8.3 ± 4.5) (P = 0.2). The mean level of FC was significantly higher in patients (239.1 ± 177.3 µg/g) than in healthy controls (38.5 ± 34.6 µg/g, P < 0.001). The titer of anti-tTG was significantly higher in patients than in healthy children (205.9 ± 156.2 U/mL vs. 6.7 ± 2.1 U/mL, respectively, P < 0.001). There was a significant correlation between the FC level and anti-tTG titer (r = 0.611, P < 0.001). However, the correlation was not statistically significant between FC and age (r = -0.154, 0.07). The ROC curve analysis revealed an AUC value of 0.893 (95% CI: 0.827 -0.960, P < 0.001). At the level of 50 µg/g, FC rendered the sensitivity and specificity of 90% and 92%, respectively, for the diagnosis of CD.Positive predictive value (PPV) and negative predictive value (NPV) of FC at this cutoff value were 95.5% and 90.5%, respectively. Conclusions: FC can be considered a screening complementary tool for detecting CD with high sensitivity and specificity.

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Section: Discussioncontrasting

confidence: 45%

Section: Discussionmentioning

confidence: 93%

Section: Study Populationmentioning

confidence: 99%

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A Survey of Fecal Calprotectin in Children with Newly Diagnosed Celiac Disease with Villous Atrophy

et al. 2019

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“…Similarly to the aforementioned study, Balamtekin et al [8] confirmed significantly higher FCC in untreated children with CD in comparison with treated children and with the control group (p < 0.001). In a group of 63 children with recently diagnosed CD, studied by Biskou et al [9], patients with CD had higher FCC than their healthy peers (36.4 mg/kg vs. 25 mg/kg).…”

Section: Discussionmentioning

confidence: 96%

Faecal calprotectin concentration in children with coeliac disease

Szaflarska-Popławska

Romańczuk

Parzęcka

2020

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Introduction: It is still unknown whether faecal calprotectin elevation may be caused by active untreated coeliac disease (CD) itself or whether it indicates the coexistence of CD and another disease associated with gastrointestinal inflammation. Aim: To assess faecal calprotectin concentration (FCC) and its correlation with the clinical form and histopathological picture of the small intestine in children with CD. Material and methods: Fifty-five children with newly recognised CD (mean age: 9.1 years) and 17 children with CD diagnosed at least year before and on a strict gluten-free diet (mean age: 12.3 years) were accepted for the study. Classical (n = 27), non-classical (n = 17), and asymptomatic form (n = 11) were distinguished in children with newly diagnosed CD based on the clinical picture. The histopathological small intestinal lesions were classified as Marsh 1 (n = 4), 3a (n = 5), 3b (n = 20), and 3c (n = 26). FCC was assessed using ELISA method with 50 µg/g as the upper limit of the normal. Results: FCC was abnormal for 21 patients with newly diagnosed CD (38.2%) and for six patients from the treated group (35.3%). Mean FCC for the analysed group of patients was 91.7 ±144.8 µg/g, in the group with newly diagnosed CD-100.9 ±154.4 µg/g, and in the treated group-61.8 ±106.2 µg/g (Z =-1.333; p = 0.183). In the group of patients with recently diagnosed CD a statistically significant relationship was not observed for FCC and both clinical picture (c 2 = 0.319, p = 0.852) and severity of small intestinal lesions according to the Marsh classification (rho = 0.136). Conclusions: Assessment of FCC seems to have no use as a marker for diagnostics and monitoring of CD irrespective of clinical form of the disease and severity of the inflammatory lesions within the small intestine.

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“…However, data on FC levels in the assessment of intestinal inflammation among patients with JIA are limited. Although Biskou, et al12 found that FC levels are not raised in children with JIA, it has been demonstrated that FC levels could be higher in JIA patients because of their use of nonsteroidal antiinflammatory drugs; however, levels returned to normal values after drug withdrawal13 . Stoll, et al found that FC levels were higher in children with ERA if compared to patients with nonspondyloarthritis subtype and unrelated connective tissue diseases, and noninflammatory control subjects…”

mentioning

confidence: 98%

Fecal Calprotectin to Detect Inflammatory Bowel Disease in Juvenile Idiopathic Arthritis

Ferrara

Pastore²,

Sancin³

et al. 2018

J Rheumatol

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Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis

Cited by 17 publications

References 11 publications

A Survey of Fecal Calprotectin in Children with Newly Diagnosed Celiac Disease with Villous Atrophy

A Survey of Fecal Calprotectin in Children with Newly Diagnosed Celiac Disease with Villous Atrophy

Faecal calprotectin concentration in children with coeliac disease

Fecal Calprotectin to Detect Inflammatory Bowel Disease in Juvenile Idiopathic Arthritis

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