Faecal calprotectin concentrations in untreated coeliac patients

Montalto, Massimo; Santoro, Luca; Curigliano, Valentina; D’Onofrio, Ferruccio; Cammarota, Giovanni; Panunzi, Simona; Ricci, Roberta; Gallo, Adele; Grieco, Antonio; Gasbarrini, Antonio; Gasbarrini, Giovanni

doi:10.1080/00365520601173632

Cited by 36 publications

(22 citation statements)

References 22 publications

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“…This fact was demonstrated in two cases of intestinal infection in the present research. Many common organic intestinal diseases, such as celiac disease (16) , diverticular disease (29) , colorectal carcinoma (20) , microscopic colitis, and allergic colitis, are not uniformly characterized by significant neutrophil infiltrate, so FC can be detected but in levels lower than those in IBD (25) . The findings of the patients from the miscellanea group corroborated this fact.…”

Section: Discussionmentioning

confidence: 99%

FECAL CALPROTECTIN: levels for the ethiological diagnosis in Brazilian patients with gastrointestinal symptoms

Kotze

Nisihara

Marion

et al. 2015

Arq. Gastroenterol.

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-Background -Determination of fecal calprotectin can provide an important guidance for the physician, also in primary care, in the differential diagnosis of gastrointestinal disorders, meanly between inflammatory bowel diseases and irritable bowel syndrome. Objectives -The aims of the present study were to prospectively investigate, in Brazilian adults with gastrointestinal complaints, the value of fecal calprotectin as a biomarker for the differential diagnosis between functional and organic disorders and to correlate the concentrations with the activity of inflammatory bowel diseases. Methods -The study included consecutive patients who had gastrointestinal complaints in which the measurement levels of fecal calprotectin were recommended. Fecal calprotectin was measured using a Bühlmann (Basel, Switzerland) ELISA kit.

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Section: Discussionmentioning

confidence: 99%

FECAL CALPROTECTIN: levels for the ethiological diagnosis in Brazilian patients with gastrointestinal symptoms

Kotze

Nisihara

Marion

et al. 2015

Arq. Gastroenterol.

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“…However, whether fecal calprotectin indicates colonic or small intestinal inflammation is not clear. Although calprotectin is well correlated with colonic inflammation, it appears less reliable for inflammation in the proximal GI tract (Summerton et al 2002;Montalto et al 2007Montalto et al , 2010Garcia-Sanchez et al 2010). …”

Section: Inflammationmentioning

confidence: 99%

The Cystic Fibrosis Intestine

Lisle

Borowitz

2013

Cold Spring Harbor Perspectives in Medicine

160

187

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“…FC is specific for inflammation, but not disease-specific, as it may, besides IBD, be elevated in those gastrointestinal inflammatory conditions where neutrophils are present (table 1). In microscopic colitis and celiac disease, the major inflammatory cell population usually constitutes of lymphocytes and therefore calprotectin concentrations in stool may remain low [27,28]. …”

Section: Calprotectinmentioning

confidence: 99%

Diagnostics and Prognostics of Inflammatory Bowel Disease with Fecal Neutrophil-Derived Biomarkers Calprotectin and Lactoferrin

Sipponen

2013

Dig Dis

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Crohn's disease (CD), ulcerative colitis (UC), and colitis unclassified, collectively defined as inflammatory bowel disease (IBD), are the consequence of chronic inflammatory reactions in the gastrointestinal tissue. Endoscopy with biopsies is the mainstay in the diagnosis of this inflammation and is also important in the assessment of disease activity and monitoring of treatment. Furthermore, mucosal healing is increasingly becoming a therapeutic target for treatment of IBD and the golden standard of assessing it is endoscopy. However, due to the costs, invasiveness, and to limited endoscopic capacity, the need is strong for reliable surrogate markers of intestinal inflammation. Bowel contents, being in close contact with intestinal mucosa, can take up molecules that are measurable from stool samples and thus can serve as markers of inflammation. The fecal neutrophil-derived biomarkers, especially calprotectin and lactoferrin, have several features of an ideal test for detecting intestinal inflammation: they are noninvasive, simple, and low in cost. The utility of these biomarkers in distinguishing IBD from noninflammatory conditions such as irritable bowel syndrome is well documented. They correlate closely with endoscopic activity both in CD and UC. They allow serial monitoring of disease activity and of treatment success, and can even serve in predicting clinical relapse in unsymptomatic patients or sustained remission after induction with TNF-α-blocking agents. In this review an overview will be given to the role of fecal neutrophil-derived biomarkers calprotectin and lactoferrin in diagnostics and prognostics of IBD.

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Faecal calprotectin concentrations in untreated coeliac patients

Abstract: This study shows, for the first time, that FCCs in untreated coeliac patients do not differ significantly from those in controls.

Cited by 36 publications

References 22 publications

FECAL CALPROTECTIN: levels for the ethiological diagnosis in Brazilian patients with gastrointestinal symptoms

FECAL CALPROTECTIN: levels for the ethiological diagnosis in Brazilian patients with gastrointestinal symptoms

The Cystic Fibrosis Intestine

Diagnostics and Prognostics of Inflammatory Bowel Disease with Fecal Neutrophil-Derived Biomarkers Calprotectin and Lactoferrin

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