Faecal calprotectin as an aid to the diagnosis of non-IgE mediated cow's milk protein allergy

Belizón, Carlos Trillo; Páez, Eduardo Ortega; Claros, Antonio Medina; Sánchez, Isabel Rodríguez; González, Ana María Reina; Medialdea, Rafael Vera; Salguero, Jose Manuel Ramón

doi:10.1016/j.anpede.2015.07.037

Cited by 14 publications

(14 citation statements)

References 17 publications

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“…In addition to GI diseases, the FC level was recently used as a diagnostic marker for various atopic and allergic diseases in children. [6][7][8][9][10] In our study, three children with high FC values had allergic diseases, In addition, numerous ongoing studies investigate the relationship of the FC levels with various bowel diseases, such as acute appendicitis, Henoch-Schönlein purpura, and colonic polyps. [23][24][25] Several studies showed that even neonates who suffered from necrotizing enterocolitis had early elevation in FC levels.…”

Section: Discussionmentioning

confidence: 73%

“…In addition to GI diseases, the FC level was recently used as a diagnostic marker for various atopic and allergic diseases in children . In our study, three children with high FC values had allergic diseases, one 34‐month‐old child with high FC value was diagnosed with cow's milk protein allergy, and other 24‐month‐old and 29‐month‐old children without food allergy had a history of atopic dermatitis.…”

Section: Discussionmentioning

confidence: 74%

“…In addition to gastrointestinal disorders, FC was recently reported as a reliable diagnostic method in cow's milk protein allergy and atopic diseases …”

Section: Introductionmentioning

confidence: 99%

“…4,5 In addition to gastrointestinal disorders, FC was recently reported as a reliable diagnostic method in cow's milk protein allergy and atopic diseases. [6][7][8][9][10] For adults and children over 4 years, a cut-off level of 50 μg/g has been well established for diagnostic purposes. 4 Normally, a high level of calprotectin was reported in healthy neonates due to the higher intestinal permeability, the establishment of gut flora, and the response to alimentary antigens.…”

Section: Introductionmentioning

confidence: 99%

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Fecal calprotectin level in healthy children aged less than 4 years in South Korea

Song

Lee

Choi

et al. 2017

Clinical Laboratory Analysis

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Background Fecal calprotectin (FC) is non‐invasive inflammatory marker indicating various bowel diseases. However, the median‐specific cut‐off values and the standard deviations (SD) of the FC levels in each age group <4 years were not elucidated. Methods Healthy volunteers were enrolled from four kindergartens. A questionnaire was used to confirm that the children met the inclusion criteria, and several demographics and history of bowel symptoms were collected. The FC level was measured. Results A total of 234 healthy children aged between 6 months and 4 years were recruited. The median FC concentration of all participants was 245 μg/g (range 12–1033 μg/g, mean 68.5 μg/g, SD 123.12 μg/g). The children were divided into six age groups. The upper limit of 95% CI of median FC values was 135 μg/g in 7–12 months group, 65 μg/g in 13–18 months group, 55 μg/g in 19–24 months group, 40 μg/g in 25–30 months group, 21 μg/g in 31–36 months group, and 12 μg/g in 37–48 months group. A negative correlation trend was found between the age and the FC concentration. Conclusion This is the first study to present the FC median levels in the specific age groups <4 years in Korea. We found a FC level reduction with age, indicating a bowel maturation process and decreased intestinal permeability of the intestinal mucosa. In our study, FC levels reached the values of 50 μg/g around the age of 2 years.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 74%

“…In addition to gastrointestinal disorders, FC was recently reported as a reliable diagnostic method in cow's milk protein allergy and atopic diseases …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Fecal calprotectin level in healthy children aged less than 4 years in South Korea

Song

Lee

Choi

et al. 2017

Clinical Laboratory Analysis

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“…Therefore, gut proteins such as β-defensin, eosinophil cationic protein, TNF-α, and calprotectin in fecal samples can act as surrogate markers of cellular response. The Table lists studies showing that estimation of FC may prove to be a useful biomarker in FPIES [2,4,5]. Beşer et al [4] showed a higher FC level in non-IgE-mediated disease before elimination of CMP that decreased after elimination of CMP, although levels were still higher than in IgE-mediated disease.…”

mentioning

confidence: 99%

Testing for Fecal Calprotectin in Food Protein–Induced Enterocolitis Syndrome

Khan

2018

J Investig Allergol Clin Immunol

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Clinical characteristics, laboratory findings, and tolerance acquisition in infants with cow's milk protein allergy in a private center in Lima, Peru for the period 2021–2022

Calle,

Díaz‐Vásquez,

Córdova‐Calderón

et al. 2024

Immunity Inflam & Disease

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BackgroundCow's milk protein allergy (CMPA) remains relatively understudied in Latin America.MethodsIn this observational study, we enrolled 64 patients with a median age of 3 months, of whom 60% were male. Patients included had a history of IgE‐mediated reactions with IgE sensitization or non‐IgE‐mediated reactions or symptoms following exposure to cow's milk. They underwent skin prick test, ImmunoCAP, fecal calprotectin (FC), and fecal eosinophil‐derived neurotoxin (EDN), in addition to double‐blinded placebo‐controlled oral food challenges (DBPCFC), with clinical evolution and tolerance acquisition observed over 1 year.ResultsMalnutrition was present in 78.1% of patients, and 87.5% had a family history of atopy, with 51.6% receiving exclusive breastfeeding. Gastrointestinal manifestations were prevalent in 90.6% of patients, followed by dermatological manifestations (10.9%), with only 2 experiencing anaphylaxis. IgE‐mediated CMPA was observed in only six patients. In those with non‐IgE‐mediated CMPA, FC had a median of 284 mg/dL (IQR: 138.5–415.5), while EDN had a median of 508.5 mg/dL (IQR: 160.25–868). One year after diagnosis, median FC significantly decreased (p < 0.0001), and malnutrition prevalence reduced to 17.1%. Moreover, 81% of patients acquired tolerance following DBPCFC, with 52% utilizing nutritional replacement formulas at diagnosis. Notably, 94% of those extensively hydrolyzed casein‐based formulas achieved tolerance (p = 0.08).ConclusionOur findings provide a foundational framework for future investigations into CMPA diagnosis, tolerance acquisition, and the utilization of hypoallergenic formulas tailored to the unique characteristics of our region.

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Faecal calprotectin as an aid to the diagnosis of non-IgE mediated cow's milk protein allergy

Cited by 14 publications

References 17 publications

Fecal calprotectin level in healthy children aged less than 4 years in South Korea

Fecal calprotectin level in healthy children aged less than 4 years in South Korea

Testing for Fecal Calprotectin in Food Protein–Induced Enterocolitis Syndrome

Clinical characteristics, laboratory findings, and tolerance acquisition in infants with cow's milk protein allergy in a private center in Lima, Peru for the period 2021–2022

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