Faecal bile acids and colorectal cell proliferation

Biasco, Guido; Paganelli, Gian Maria; Owen, R. W.; Hill, Michael J.

doi:10.1097/00008469-199110002-00011

Cited by 9 publications

(2 citation statements)

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“…animalis DN‐173 010 ingestion did not influence the faecal excretion of secondary bile salts. We believe that this is a good thing, as secondary bile salts may increase the risk of colon cancer 22–24 . The shortening of the colonic transit time was therefore not due to significant bile salt modifications.…”

Section: Discussionmentioning

confidence: 84%

Bifidobacterium animalis strain DN‐173 010 shortens the colonic transit time in healthy women: a double‐blind, randomized, controlled study

Marteau

Cuillerier

Meance

et al. 2002

Aliment Pharmacol Ther

212

131

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Background: A previous study has suggested that Bifidobacterium animalis DN‐173 010 shortens the colonic transit time in women. Aim: To confirm this effect and to determine whether modifications of the faecal bacterial mass and/or faecal secondary bile salts may be the explanation. Methods: A double‐blind, cross‐over study was performed. Thirty‐six healthy women were studied in four consecutive 10‐day periods. During periods 2 and 4, they ingested three 125 g cups per day of a fermented milk which was either a product containing B. animalis DN‐173 010 or a control without bifidobacteria. Periods 1 and 3 were run‐in and washout periods, respectively. The total and segmental colonic transit times were assessed using a pellet method. In 12 subjects, all stools were collected and analysed for pH, faecal weight, bacterial mass and bile acids. Results: The total and sigmoid transit times were significantly shorter during dosing with B. animalis compared to the control period. The other transit times, faecal weight, pH, bacterial mass and bile acids were not significantly affected. Conclusions: B. animalis DN‐173 010 shortens the colonic transit time in healthy women. This effect is not explained by modifications of the faecal bacterial mass or secondary bile acids.

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Section: Discussionmentioning

confidence: 84%

Bifidobacterium animalis strain DN‐173 010 shortens the colonic transit time in healthy women: a double‐blind, randomized, controlled study

Marteau

Cuillerier

Meance

et al. 2002

Aliment Pharmacol Ther

212

131

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“…However, while a potentially pro-oncogenic cytokine profile has been reported in NAFLD [72,73], little is known about changes of the bile acid composition in NAFLD. However, the finding that gallstones in NAFLD patients go often in parallel with increasing insulin resistance further suggests that altered bile composition might also play a role in the development of colorectal cancer [74][75][76].…”

Section: Iic Biological Basis For the Development Of Extrahepatic Can...mentioning

confidence: 99%

Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD

Lonardo¹,

Sookoian²,

Chonchol³

et al. 2013

CPD

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Non-alcoholic fatty liver disease (NAFLD) encompasses pure steatosis through nonalcoholic steatohepatitis (NASH) and is the most common cause of chronic liver disease in Western countries. NASH is a progressive liver disease that increases the risk of cirrhosis and end-stage liver disease. Interestingly, the global health risk of NAFLD is not confined to the liver. Compared with those without NAFLD, patients with NAFLD exhibit not only increased liver-related complications and liver-related mortality but also increased risk of developing type 2 diabetes, cardiovascular disease (CVD) and chronic kidney disease, increased risk of post-operative complications after major liver surgery, and increased risk of developing certain malignancies, including primary liver cancer and colorectal cancer. In this review, we discuss the current evidence linking NAFLD with the risk of CVD in the setting of the more complex scenario of other hepatic and extra-hepatic complications that may occur during the natural course of NAFLD. Moreover, we provide a brief description of the putative biological mechanisms underlying such complications, particular emphasis being given to CVD. We conclude that NAFLD is a complex health problem with implications far beyond the liver. Hence, it may cause a significant global health burden and the assistance of patients with NAFLD impacts on the work of physicians from many different medical specialties.

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Cell proliferation biomarkers in the gastrointestinal tract

et al. 1992

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Measurements of epithelial cell proliferation in the mucosa of the gastrointestinal tract pointed out the existence of cell kinetic abnormalities which can be involved in the first steps of carcinogenesis. In particular, an increase in the cell proliferation rate and an abnormal distribution of proliferating cells were found both in animals exposed to carcinogens and in human subjects at high risk of gastrointestinal cancer. In some diseases which predispose to cancer (Le., chronic atrophic gastritis, hereditary gastrointestinal cancer, sporadic colorectal neoplasia, chronic ulcerative colitis) we observed an expansion of the proliferative compartment even when the mucosa was not affected by morphological abnormalities. This proliferative feature seems to be associated with the presence of defects in cell differentiation. The abnormality is well detected by the histological examination of the proliferative pattern using microautoradiography after incorporation of tritiated thymidine, or using immunohistochemistry after bromodeoxyuridine uptake. The literature, and our own results, indicate that the search for abnormalities of epithelial cell proliferation can be useful in studying the earliest mechanisms leading to gastrointestinal cancer, in detecting subjects at high cancer risk, and for pilot chernoprevention studies using these abnormalities as intermediate biomarkers of gastrointestinal cancer risk. 0 1992 Wiley-Liss, Inc.

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Faecal bile acids and colorectal cell proliferation

Cited by 9 publications

References 0 publications

Bifidobacterium animalis strain DN‐173 010 shortens the colonic transit time in healthy women: a double‐blind, randomized, controlled study

Bifidobacterium animalis strain DN‐173 010 shortens the colonic transit time in healthy women: a double‐blind, randomized, controlled study

Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD

Cell proliferation biomarkers in the gastrointestinal tract

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