Faecal analysis and plasma complement factor 3c levels at admission for an acute attack of ulcerative colitis are predictive of the need for colectomy

Pagoldh, Maria; Lange, Stefan; Jennische, Eva; Almér, Sven; Boström, Elisabeth A.; Eriksson, Anders

doi:10.1097/meg.0000000000000042

Cited by 2 publications

(1 citation statement)

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“…In early clinical studies, complement activation was shown to be associated with the progression of UC and CD. The synthesis of complement components in the intestine of UC patients might be part of the local inflammatory amplification process . In our study, we found that serum FCN‐2/A increased in both patients with IBD and in mice with acute colitis.…”

Section: Discussionmentioning

confidence: 99%

Ficolin‐A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis

Yang

Zhou

et al. 2017

Immunology

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Human ficolin-2 (FCN-2) and mouse ficolin-A (FCN-A, a ficolin-2-like molecule in mouse) are activators of the lectin complement pathway, present in normal plasma and usually associated with infectious diseases, but little is known about the role of FCN-A/2 in inflammatory bowel disease (IBD). In our present study, we found that patients with IBD exhibited much higher serum FCN-2 levels than healthy controls. In the dextran sulphate sodium-induced acute colitis mouse model, FCN-A knockout mice showed much milder disease symptoms with less histological damage, lower expression levels of pro-inflammatory cytokines [interleukin-6 (IL-6), IL-1β and tumour necrosis factor-α (TNF-α)], chemokines (CXCL1/2/10 and CCL4) and higher levels of the anti-inflammatory cytokine IL-10 compared with wild-type mice. We demonstrated that FCN-A/2 exacerbated the inflammatory pathogenesis of IBD by stimulating M1 polarization through the TLR4/MyD88/MAPK/NF-κB signalling pathway in macrophages. Hence, our data suggest that FCN-A/2 may be used as a novel therapeutic target for IBD.

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Section: Discussionmentioning

confidence: 99%

Ficolin‐A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis

Yang

Zhou

et al. 2017

Immunology

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A review of human diseases caused or exacerbated by aberrant complement activation

McGeer

Lee

McGeer

2017

Neurobiology of Aging

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Faecal analysis and plasma complement factor 3c levels at admission for an acute attack of ulcerative colitis are predictive of the need for colectomy

Abstract: Early faecal analysis and measurement of complement factor 3c may be useful as predictive markers of the need for colectomy related to a severe attack of ulcerative colitis.

Cited by 2 publications

References 28 publications

Ficolin‐A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis

Ficolin‐A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis

A review of human diseases caused or exacerbated by aberrant complement activation

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