Faculty Opinions recommendation of Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives.

Bothwell, Mark

doi:10.3410/f.13614956.15010056

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature 2012

DOI: 10.3410/f.13614956.15010056

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Faculty Opinions recommendation of Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives.

Mark Bothwell

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2023

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Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy

Ávila

Pérez

Ávila-Villanueva

et al. 2023

Explor Neuroprot Ther

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Currently, the predominant targets for the treatment of Alzheimer’s disease (AD) are the main components of the two pathological structures: senile plaques (composed of amyloid beta peptide aggregates) or neurofibrillary tangles (constructed of tau protein polymers). However, the existence of adequate disease modifiers based on such targets is discussed. In this special issue, it has been suggested to search for new possible targets for AD therapy. This contribution tries to analyze non-neuronal tissues (periphery) to identify potential factors (target) involved in the development of AD.

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Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy

Ávila

Pérez

Ávila-Villanueva

et al. 2023

Explor Neuroprot Ther

View full text Add to dashboard Cite

show abstract

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Faculty Opinions recommendation of Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives.

Cited by 1 publication

References 0 publications

Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy

Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy

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