Factors which affect the diastolic pressure-volume curve.

Factors contributing to altered left ventricular diastolic properties during angina pectoris.

“…Finally, an important role for the pericardium in enhancing "mechanical coupling" of the ventricles has been suggested. 25 In the present study, right ventricular end-diastolic pressure did not increase during angina in the immediate post-pacing period, although left ventricular end-diastolic pressure nearly doubled. If altered right ventricular afterload (right ventricular systolic pressure rose from 31 ± 2 mm Hg to 39 ± 2 mm Hg) 16 CIRCULATION 30 recently demonstrated in isolated rabbit hearts that increases in coronary perfusion pressure resulted in increases in ventricular "effective stiffness," and that these changes in ventricular stiffness were parallel to acute substantial changes in wall thickness.…”

“…Many factors influence the left ventricle in diastole, but the completeness of ventricular relaxation and external diastolic constraints of the ventricle are among the most important.5' [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] With regard to external constraints, attention has focused on the influence of the pericardium, right ventricular loading, and coronary perfusion pressure" [18][19][20][21][22][23][24][25]30 on left ventricular diastolic compliance. Glantz and Parmley have suggested that during ischemia induced by atrial pacing, increased rightsided volume and pressure cause the left ventricular diastolic pressure-volume curve to shift upward as a result of "direct mechanical coupling between the two ventricles," enhanced by the intact pericardium.5 They cite data of Weiss et al 26 as being inconsistent with the concept that impaired relaxation is playing a major role in causing the altered left ventricular diastolic pressures, as had been suggested by several investigators.4 ' 6, 12, 13, 15, 16 The present study was designed to examine the role of altered right ventricular loading and pericardial influences on the increased left ventricular diastolic pressure during angina.…”

Experimentally verified minimal cardiovascular system model for rapid diagnostic assistance

“…Experimental data found in the literature usually involved surgically removing the heart from the circulation system and investigating static responses [Maughan et al, 1987;Weber et al, 1981;Glantz and Parmley, 1978;Santamore and Dell'Italia, 1998]. Fluid is injected into one side of the heart, and the eect on the other side of the heart is investigated.…”

Changes in pericardial pressure during the perinatal period.

“…28 The apparent increase in stroke work observed at equal end-diastolic pressures ( Figure 2C) could suggest that contractility increased after ventilation.29 However, analysis of the cardiac function curves in which more reliable measures of preload (left ventricular end-diastolic diameter [ Figure 2A] or left ventricular end-diastolic transmural pressure [ Figure 2C]) are used strongly suggests that the increase in cardiac function results solely from an increase in preload. Because end-diastolic pressure does not accurately reflect left ventricular preload, end-diastolic pres-sure should not be used uncritically to assess cardiac function.29 A shift in the diastolic pressure-volume relation ( Figure 2B) can produce a shift in the conventional ventricular function curve (i.e., stroke work versus left ventricular end-diastolic pressure, Figure 2A) even when contractility remains constant ( Figure 2C; see also Figure 6 of Reference 28).…”