Factors that differentiate early vs. later onset of major depression disorder

Zisook, Sidney; Rush, A. John; Albala, A. Ariav; Alpert, Jonathan E.; Balasubramani, G.K.; Fava, Maurizio; Husain, Mustafa M.; Sackeïm, Harold A.; Trivedi, Madhukar H.; Wisniewski, Stephen R.

doi:10.1016/j.psychres.2004.07.004

Cited by 127 publications

(111 citation statements)

References 58 publications

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“…However, it is also possible that this finding represents a cohort effect, whereby younger individuals may have an earlier age of onset, perhaps due to increased societal pressures regarding appearance. Given that earlier age of onset may be associated with greater severity of mental illness (Zisook et al, 2004;Gollan et al, 2005), the earlier onset of BDD in our adolescents is also consistent with the possibility that adolescents represent a more severe subset of individuals with BDD. Although adolescents did not differ from adults on most severity measures, a higher proportion of adolescents had attempted suicide and were delusional.…”

Section: Discussionsupporting

confidence: 79%

Clinical features of body dysmorphic disorder in adolescents and adults

Phillips

Didie

Menard

et al. 2006

Psychiatry Research

185

128

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Body dysmorphic disorder (BDD) usually begins during adolescence, but its clinical features have received little investigation in this age group. Two hundred individuals with BDD (36 adolescents; 164 adults) completed interviewer-administered and self-report measures. Adolescents were preoccupied with numerous aspects of their appearance, most often their skin, hair, and stomach. Among the adolescents, 94.3% reported moderate, severe, or extreme distress due to BDD, 80.6% had a history of suicidal ideation, and 44.4% had attempted suicide. Adolescents experienced high rates and levels of impairment in school, work, and other aspects of psychosocial functioning. Adolescents and adults were comparable on most variables, although adolescents had significantly more delusional BDD beliefs and a higher lifetime rate of suicide attempts. Thus, adolescents with BDD have high levels of distress and rates of functional impairment, suicidal ideation, and suicide attempts. BDD's clinical features in adolescents appear largely similar to those in adults.

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Section: Discussionsupporting

confidence: 79%

Clinical features of body dysmorphic disorder in adolescents and adults

Phillips

Didie

Menard

et al. 2006

Psychiatry Research

185

128

View full text Add to dashboard Cite

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“…ajor depressive disorder (MDD) is common in adolescents and is associated with high risk of recurrence, comorbidity, future disability, and suicide (Weissman et al 1997;Ustün et al 2004;Zisook et al 2004Zisook et al , 2007Kennard et al 2009). First-line interventions for adolescent MDD include structured psychotherapies (e.g., cognitive behavioral therapy and interpersonal psychotherapy) as well as antidepressants from the selective serotonin reuptake inhibitor (SSRI) class (Aacap 1998).…”

mentioning

confidence: 99%

Neural Correlates of Antidepressant Treatment Response in Adolescents with Major Depressive Disorder

Cullen

Klimes‐Dougan

et al. 2016

Journal of Child and Adolescent Psychopharmacology

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Objective: The neural changes underlying response to antidepressant treatment in adolescents are unknown. Identification of neural change correlates of treatment response could (1) aid in understanding mechanisms of depression and its treatment and (2) serve as target biomarkers for future research. Method: Using functional magnetic resonance imaging, we examined changes in brain activation and functional connectivity in 13 unmedicated adolescents with major depressive disorder (MDD) before and after receiving treatment with a selective serotonin reuptake inhibitor medication for 8 weeks. Specifically, we examined brain activation during a negative emotion task and resting-state functional connectivity (RSFC), focusing on the amygdala to capture networks relevant to negative emotion. We conducted whole-brain analyses to identify how symptom improvement was related to change in brain activation during a negative emotion task or amygdala RSFC. Results: After treatment, clinical improvement was associated with decreased task activation in rostral and subgenual anterior cingulate cortex and increased activation in bilateral insula, bilateral middle frontal cortices, right parahippocampus, and left cerebellum. Analysis of change in amygdala RSFC showed that treatment response was associated with increased amygdala RSFC with right frontal cortex, but decreased amygdala RSFC with right precuneus and right posterior cingulate cortex. Conclusion: The findings represent a foothold for advancing understanding of pathophysiology of MDD in adolescents by revealing the critical neural circuitry changes that underlie a positive response to a standard treatment. Although preliminary, the present study provides a research platform for future work needed to confirm these biomarkers at a larger scale before using them in future target engagement studies of novel treatments.

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“…[22] Yapılan çalışmalarda atipik major depresyonu olanlarda, atipik olmayan gruba göre kadın cinsiyetin daha sık olduğu bildirilmiştir. [19,20,[23][24][25][26][27][28][29][30][31][32][33][34][35] Angst ve arkadaşlarına göre bu oran kadınlarda yaklaşık olarak 4 kat daha yüksek-tir. [11] Nörobiyolojisi Atipik depresyonun nörobiyolojisini inceleyen çalışmalar çeşitli gruplara ayrılmaktadır.…”

Section: Epidemiyolojiunclassified

“…[27] Başka bir çalışmada ise erken başlangıçlı depresyon ile kronisitenin (hastalık süresinin ve şimdiki atak süresinin daha uzun olması, daha yüksek atak sayısı) ve atipiklik arasında bir ilişki olduğu bulunmuştur. [33] Atipik depresyonu olan hastaların depresyonu atipik olmayanlara göre daha fazla özkıyım düşüncesine sahip oldukları ve atklardaki belirti şiddetinin daha yüksek olduğu bildirilmektedir. [13,25] Ayrıca atipik depresyonu olanların sağlık kuruluşlarına daha sık başvurdukları, daha çok ruhsal tedavi arayışı-na girdikleri ve daha fazla sayıda antidepresan kullanımı öyküsüne sahip oldukları saptanmıştır.…”

Section: Klinik Gidiş Ve Prognozunclassified

Atypical Depression

Koyuncu¹,

Binbay²,

Ertekin³

et al. 2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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Atypical depression is defined as a specifier of major depressive disorder. Columbia criteria for atypical depression are commonly used to make a diagnosis. Female sex, onset at early age, chronic course, and higher rate of comorbidity (especially anxiety disorder and bipolar disorder) is noteworthy in atypical depression. Although, the atypical depression seems to support the familial genetic transition, there is not any specific study supporting these data. In the treatment of atypical depression, monoamine oxidase inhibitors are reported to be more effective than tricyclic antidepressants. In recent studies, selective serotonin reuptake inhibitors have also proven to be efficient

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Factors that differentiate early vs. later onset of major depression disorder

Cited by 127 publications

References 58 publications

Clinical features of body dysmorphic disorder in adolescents and adults

Clinical features of body dysmorphic disorder in adolescents and adults

Neural Correlates of Antidepressant Treatment Response in Adolescents with Major Depressive Disorder

Atypical Depression

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