Factors Relating to the Biodistribution &amp; Clearance of Nanoparticles &amp; Their Effects on
            <i>In Vivo</i>
            Application

Wei, Yanchun; Li, Quan; Zhou, Chao; Zhan, Qiuqiang

doi:10.2217/nnm-2018-0040

Cited by 141 publications

(89 citation statements)

References 149 publications

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“…Renal excretion is particularly relevant for NCs below the threshold value (ca. 5.5 nm) [25]. MPS clearance is operated by liver>spleen>lung phagocytes.…”

Section: Sizementioning

confidence: 96%

Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope

Salvioni

Rizzuto

Bertolini

et al. 2019

Cancers

142

138

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Starting with the enhanced permeability and retention (EPR) effect discovery, nanomedicine has gained a crucial role in cancer treatment. The advances in the field have led to the approval of nanodrugs with improved safety profile and still inspire the ongoing investigations. However, several restrictions, such as high manufacturing costs, technical challenges, and effectiveness below expectations, raised skeptical opinions within the scientific community about the clinical relevance of nanomedicine. In this review, we aim to give an overall vision of the current hurdles encountered by nanotherapeutics along with their design, development, and translation, and we offer a prospective view on possible strategies to overcome such limitations.

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“…Renal excretion is particularly relevant for NCs below the threshold value (ca. 5.5 nm) [25]. MPS clearance is operated by liver>spleen>lung phagocytes.…”

Section: Sizementioning

confidence: 96%

Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope

Salvioni

Rizzuto

Bertolini

et al. 2019

Cancers

142

138

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“…The sphere volume‐to‐surface area ratio equals diameter/6; therefore, microcapsules appear to be more efficient for encapsulation than nanocapsules when compared solely based on the volume available for loading of the active substance. However, LNPs with diameters of around 200 nm exhibited benefits over larger particles in drug delivery to cancer cells . In contrast to problems encountered elsewhere (e.g., analysis, colloids), the (self‐)aggregation tendency of lignins can be exploited in the formation of capsules, that is, structures comprised per definition of a core–shell construct; shells can be of varying rigidity, cores can be solid or liquid.…”

Section: Entrapment Encapsulation and Adsorption Of Active Substancmentioning

confidence: 99%

Lignin for Nano‐ and Microscaled Carrier Systems: Applications, Trends, and Challenges

et al. 2019

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To liberate society from its dependence on fossil‐based fuels and materials it is pivotal to explore components of renewable plant biomass in applications that benefit from their intrinsic biodegradability, safety, and sustainability. Lignin, a byproduct of the pulp and paper industry, is a plausible material for carrying various types of cargo in small‐ and large‐scale applications. Herein, possibilities and constraints regarding the physical–chemical properties of the lignin source as well as modifications and processing required to render lignins suitable for the loading and release of pesticides, pharmaceuticals, and biological macromolecules is reviewed. In addition, the technical challenges, regulatory and toxicological aspects, and future research needed to realize some of the promises that nano‐ and microscaled lignin materials hold for a sustainable future are critically discussed.

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“…Research has shown that nanoparticle size is an important factor for their in vivo distribution and clearance. 31 The results suggested that the size of NPs was suitable for their in vivo application. FT-IR (Fourier Transform Infrared Spectroscopy) spectra of oleylamine-coated UCNs and IR-806/PL-PEG-coated UCNs are shown in Figure 2E.…”

Section: Resultsmentioning

confidence: 97%

<p>Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy</p>

Wei¹,

Liu²,

Pan³

et al. 2020

IJN

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Background: Photothermal therapy with accurate and real-time temperature detection is desired in clinic. Upconversion nanocrystals (UCNs) are candidate materials for simultaneous temperature detection and photothermal agents carrying. However, the weak luminescence and multiple laser excitations of UCNs limit their application in thermal therapy. Materials and Methods: NaYF 4 :Yb 3+ ,Er 3+ ,Nd 3+ , PL-PEG-NH 2 , IR-806 and folic acid are selected as structural components. A nanoprobe (NP) integrated with efficient photothermal conversion and sensitive temperature detection capabilities is synthesized for precise photothermal therapy. The probes are based on near-infrared upconversion nanocrystals doped with Yb, Er and Nd ions, which can be excited by 808 nm light. IR-806 dye molecules are modified on the surface as molecular antennas to strongly absorb near-infrared photons for energy transfer and conversion. Results: The results show that under an 808 nm laser irradiation upconversion luminescence of the nanocrystals is enhanced based on both the Nd ion absorption and the FRET energy transfer of IR-806. The luminescence ratio at 520 and 545 nm is calculated to accurately monitor the temperature of the nanoparticles. The temperature of the nanoprobes increases significantly through energy conversion of the molecular antennas. The nanoparticles are found successfully distributed to tumor cells and tumor tissue due to the modification of the biocompatible molecules on the surface. Tumor cells can be killed efficiently based on the photothermal effect of the NPs. Under the laser irradiation, temperature at mouse tumor site increases significantly, tissue necrosis and tumor cell death can be observed. Conclusion: Precision photothermal therapy can thus be achieved by highly efficient nearinfrared light absorption and accurate temperature monitoring, making it promising for tumor treatment, as well as the biological microzone temperature detection.

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Factors Relating to the Biodistribution & Clearance of Nanoparticles & Their Effects on In Vivo Application

Cited by 141 publications

References 149 publications

Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope

Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope

Lignin for Nano‐ and Microscaled Carrier Systems: Applications, Trends, and Challenges

<p>Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy</p>

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