Factors related to surgical complications and their impact on the functional status in 236 open surgeries for malignant tumors in a Latinoamerican hospital

Rabadán, Alejandra T.; Hernández, D; Eleta, Martín; Pietrani, Marcelo; Baccanelli, Matteo; Christiansen, Stefan; Teijido, C.A.

doi:10.1016/j.surneu.2006.11.050

Cited by 26 publications

(23 citation statements)

References 17 publications

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“…We identified that increasing age was associated with higher postoperative mortality after craniotomy for glioma resection. This is in agreement with most prior literature on glioma surgery, although some studies have found no association (5,12,16,19,22,23). In national-level investigations, using the NIS (1, 3, 14), older age was associated with higher in-hospital mortality for patients undergoing resections of brain tumors.…”

Section: Discussionsupporting

confidence: 90%

Craniotomy for Glioma Resection: A Predictive Model

et al. 2015

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Section: Discussionsupporting

confidence: 90%

Craniotomy for Glioma Resection: A Predictive Model

et al. 2015

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“…This value is higher than the rates reported by several other single-institution series, and yet, all other studies were composed of younger patient populations. 23,24,26,27 For example, a 1.8% rate of pulmonary complication was reported by Tan et al among adult-aged patients who underwent image-guided craniotomies by a single surgeon for the treatment of brain metastases. 39 The median age of the patients in this study was only 58 years, compared with our median age of 71 years.…”

Section: Discussionmentioning

confidence: 98%

“…24–26,37 Barker et al in a NIS-based study found that age was an important predictor of death among patients of all ages who underwent craniotomy for resection of brain metastases. However, this study did not specifically report the relative odds of death among the elderly.…”

Section: Discussionmentioning

confidence: 99%

“…This value is compatible with other single-institution studies, whose values varied from 8–32%. 20,21,23,24,26,27,38 This wide range of complications is associated with the widely varying number of complications studied in these different reports. For example, in the current study we focused on systemic complications, which may explain the relatively low overall complication rate.…”

Section: Discussionmentioning

confidence: 99%

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Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors

et al. 2010

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Objective Risks of brain surgery in elderly patients with brain metastases are not well defined. This study was designed to quantify the postoperative risk for these patients after brain surgery for metastatic disease to the brain. Methods We performed a retrospective analysis of the Nationwide Inpatient Sample (1998–2005). Patients aged 65 years or older who underwent tumor resection of brain metastases were identified by ICD-9 coding. Primary outcome was inpatient death. Other outcomes included systemic postoperative complications, length of stay (LOS), and total charges. Results A total of 4,907 patients (53.6% men) were identified. Mean age was 72.1 years. Mean Charlson comorbidity score was 7.8. Inpatient mortality was 4%. The most common adverse events were pulmonary complications (3.4%). Mean length of stay was 9.2 days. Mean total charges were $57,596.39. In multivariate analysis, patients up to age 80 years had no significantly greater odds of inpatient death, relative to their 65- to 69-year-old counterparts. Each 1-point increase in Charlson score was associated with 12% increased odds of death, 0.52 days increased LOS, and $1,710.61 higher hospital charges. Postoperative pulmonary complications, stroke, or thromboembolic events increased LOS and total charges by up to 9.6 days and $57,664.42, respectively. These associations were statistically significant (P < 0.05). Conclusions Surgical resection of brain metastases among the elderly up to the ninth decade of life is feasible. Age older than 80 years and higher Charlson comorbidity scores were found to be important prognostic factors for inpatient outcome. Incorporating these factors into preoperative decision making may help to select appropriately those elderly candidates for neurosurgical intervention.

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“…There are several single-institution or regional analyses with conflicting results on the effect of age on mortality (5,12,16,20,23,24). Studies of national databases have shown equally divergent results.…”

Section: Discussionmentioning

confidence: 99%