Factors Related to Persistence of Legionella Urinary Antigen Excretion in Patients with Legionnaires' Disease

Sopena, Nieves; Sabrià, Miquel; Pedro-Botet, M. L.; Reynaga, Esteban; García-Núñez, Marian; Domínguez, José; Matas, Lurdes

doi:10.1007/s10096-002-0839-5

Cited by 45 publications

(15 citation statements)

References 13 publications

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“…Water samples from the patients' home were investigated, but the source of the infection was not determined. The Legionella urinary antigen still tested positive one year later, which has been described in patients with a long-term defervescence of fever (Table 1) [4]. The patient remained well at the time of the follow-up examination at 2 years.…”

Section: Case Presentationmentioning

confidence: 68%

Legionellosis and Lung Abscesses: Contribution ofLegionellaQuantitative Real-Time PCR to an Adapted Followup

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Tellini²,

Flamens

et al. 2013

Case Reports in Infectious Diseases

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We report a case of severe Legionnaires' disease (LD) complicated by a lung abscess in an immunocompetent patient who required ECMO therapy and thoracic surgery. The results of repeated Legionella quantitative real-time PCR performed on both sera and respiratory samples correlated with the LD severity and the poor clinical outcome. Moreover, the PCR allowed for the detection of Legionella DNA in the lung abscess specimen, which was negative when cultured for Legionella. This case report provides a logical basis for further investigations to examine whether the Legionella quantitative PCR could improve the assessment of LD severity and constitute a prognostic marker.

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Section: Case Presentationmentioning

confidence: 68%

Legionellosis and Lung Abscesses: Contribution ofLegionellaQuantitative Real-Time PCR to an Adapted Followup

Descours

Tellini²,

Flamens

et al. 2013

Case Reports in Infectious Diseases

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“…L. pneumophila serogroup 1 is most commonly associated with Legionnaires' disease and this test is sensitive and highly speci¢c for serogroup 1 only. If L. pneumophila serogroup 1 had been the infecting strain, we would have expected the urinary antigen test to still be positive in this patient (even after 4 weeks), because urinary antigen excretion in immunosuppressed patients is prolonged ( 60 days), whereas antigen excretion was o60 days in immunocompetent patients (5). Our experience with culture-con¢rmed cases showed that the duration of antigen excretion in most patients was o30 days (6).…”

Section: Guest Editorialmentioning

confidence: 87%

Editor's introduction to guest editorial

Rubin¹

2004

Transplant Infectious Dis

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“…Les antigènes urinaires de Legionella apparaissent dans les urines dès les premiers jours de l'infection (en 1 à 4 jours) et restent détectables 3 à 8 semaines, voire un an chez certains patients immunodéprimés [25]. Ils peuvent être détectés même après la mise en route d'un traitement antibiotique adapté [26,27].…”

Section: Tdr Legionella Spunclassified

Description et place des techniques bactériologiques dans la prise en charge des infections pulmonaires

Dahyot

Lemée

Pestel-Caron

2017

Revue des Maladies Respiratoires

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Acute pneumonias occur in a variety of clinical settings and accurate identification of bacterial causes is extremely important. No microbiological tool is either 100 % sensitive or 100 % specific, and despite investigations, aetiology remains unanswered in more than 30 % of pneumonia. No sample may be necessary for patients treated as outpatients, non invasive respiratory specimens are preferred in hospitalised individuals (community or healthcare associated), while invasive specimens are used as second line for community acquired pneumonia (CAP) in intensive care, and in the first line where pneumonia occurs in immunosuppressed patients. Bacterial cultures have an important place, if the sample is taken before the introduction of antibiotic therapy. Some contexts may justify the use of blood cultures, testing for urinary antigens or serology. PCR is already becoming available as a daily service but the short-term future probably belongs to molecular multiplex panels capable of detecting many microorganisms within hours, especially in severe CAP resuscitation and in pneumonia in the immunosuppressed. High-throughput sequencing nucleotide techniques will soon revolutionize microbiological diagnosis in respiratory medicine, as in other areas of infectious diseases.

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Factors Related to Persistence of Legionella Urinary Antigen Excretion in Patients with Legionnaires' Disease

Cited by 45 publications

References 13 publications

Legionellosis and Lung Abscesses: Contribution ofLegionellaQuantitative Real-Time PCR to an Adapted Followup

Legionellosis and Lung Abscesses: Contribution ofLegionellaQuantitative Real-Time PCR to an Adapted Followup

Editor's introduction to guest editorial

Description et place des techniques bactériologiques dans la prise en charge des infections pulmonaires

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