Factors Related to High-sensitivity Cardiac Troponin T Levels in Pre-dialysis Chronic Kidney Disease Patients

Raikou, Vaia D; Vlaseros, Giannis; Kyriaki, Despina; Gavriil, Sotiris

doi:10.14218/erhm.2021.00074

Cited by 1 publication

(1 citation statement)

References 24 publications

(32 reference statements)

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“…Diabetes, hypertension, previous history of coronary artery disease, and cerebrovascular accident were found in this study to be associated with elevated concentrations of h-cTnT, which have been reported by other studies [24,43,44]. Findings of higher serum h-cTnT in diabetic HD patients are consistent with previous data from HD patients reported by others [36].…”

Section: Plos Onesupporting

confidence: 92%

Exploring the relation between Interleukin-6 and high-sensitive cardiac troponin T in asymptomatic hemodialysis patient: A cross-sectional study

Ibrahim,

Yasin,

Abbas

et al. 2024

PLoS ONE

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Background High-sensitive cardiac troponin T (h-cTnT), which serves as a marker for myocardial damage, has also been linked to adverse outcomes in asymptomatic hemodialysis patients. This study aims to explore the correlation between interleukin-6 (IL-6) and h-cTnT in asymptomatic hemodialysis patients to unravel the relationship between inflammation and cardiovascular risk. Methods A cross-sectional study involving 81 patients was conducted from November 2022 to March 2023 at An-Najah National University Hospital in Palestine. We gathered clinical data, including comorbidities, and obtained blood samples for measuring IL-6 and h-cTnT levels. We performed statistical analyses, including correlation tests and linear regression, to assess the associations between these variables. Results The study revealed a notable increase in both h-cTnT and IL-6 levels, and a significant correlation between the two (rho = 0.463, P<0.001) in asymptomatic hemodialysis patients. Likewise, h-cTnT levels displayed positive correlations with age (rho = 0.519, P<0.001) and negative correlations with albumin (rho = -0.297, p = 0.007) and transferrin saturation (rho = -0.227, P = 0.042). IL-6 levels exhibited correlations with age (rho = 0.422, P<0.001), albumin (rho = -0.389, P<0.001), iron (rho = -0.382, P<0.001), and transferrin saturation (rho = -0.362, P = 0.001). Notably, higher h-cTnT levels were associated with diabetes, hypertension, a history of coronary artery disease, cerebrovascular accidents, older age, and male gender. Conclusion This study underscores the significant association between the inflammatory marker IL-6 and h-cTnT in asymptomatic hemodialysis patients, suggesting that inflammation may play an essential role in the elevation of h-cTnT levels. This association may have implications for predicting cardiovascular events and guiding interventions to reduce cardiovascular disease morbidity and mortality in hemodialysis patients.

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