Factors related to health-related quality of life in ankylosing spondylitis, overall and stratified by sex

Law, Lucy; Rehnman, Jeannette Beckman; Deminger, Anna; Klingberg, Eva; Jacobsson, Lennart; Forsblad-d’Elia, Helena

doi:10.1186/s13075-018-1784-8

Cited by 61 publications

(63 citation statements)

References 44 publications

(56 reference statements)

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“…Therefore, based on both results, the second hypothesis, that the level of anxiety and pain would increase at the first tube replacement, compared to the levels of pain and anxiety presented before implantation, was not confirmed. These result coincides with other studies ( 35 - 38 ) . Regarding the gender difference in anxiety, other articles ( 39 ) suggest that there may be factors intrinsic to the female gender that predispose them to present more comorbidities, such as biochemical, hormonal and/or social aspects, that explain the differences per genus.…”

Section: Discussionsupporting

confidence: 94%

Quality of life, pain and anxiety in patients with nephrostomy tubes

Cacho

Ayesa-Arriola

2019

Rev. Latino-Am. Enfermagem

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Objective: to evaluate the impact on the quality of life as well as anxiety and pain in patients with nephrostomy tubes. Method: this is a longitudinal descriptive study performed on a sample of n=150 patients. To evaluate the quality of life, the EuroQol-5D questionnaire was used; anxiety was quantified by the Beck Anxiety Inventory; to study pain, a visual analogue scale was employed. Results: statistically significant differences were found in the quality of life, with its worsening (r = 0.51; p <0.01) when evaluated at the first tube replacement. Patients presented mild to moderate anxiety before the procedure, which was reduced at the first tube replacement, although this difference was not significant (r = 0.028, p = 0.393). Finally, the degree of pain was also significantly reduced (r = 0.13, p<0.01) after six weeks. As for gender, women presented the worst values in the three variables studied (worse quality of life and greater anxiety and pain). Conclusions: nephrostomy tubes have a negative impact on the patient’s quality of life. During the time they live with these tubes, patients have mild to moderate pain and anxiety.

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Section: Discussionsupporting

confidence: 94%

Quality of life, pain and anxiety in patients with nephrostomy tubes

Cacho

Ayesa-Arriola

2019

Rev. Latino-Am. Enfermagem

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“…Previous studies have shown that patients with ax-SpA report HRQOL scores that are similar to those reported for other inflammatory diseases [2,10], but lower than those in healthy controls [1,4,[11][12][13]. Women with the ax-SpA report lower HRQOL than men [14][15][16], and decreased HRQOL in patients with ax-SpA is associated with fatigue [17], increased disease activity, decreased daily activity and exercise [4,[18][19][20], pain, and adverse psychological factors such as body-image disturbance, anxiety and depression [21,22].…”

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confidence: 62%

No deterioration in health-related quality of life in patients with axial spondyloarthritis followed for 5 years in ordinary outpatient clinics in the biological treatment era

et al. 2019

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Background Axial spondyloarthritis (ax-SpA) causes pain, fatigue, stiffness, loss of physical function and impaired healthrelated quality of life (HRQOL). Aims The study aimed to explore the changes in HRQOL over 5 years in patients with ax-SpA and to identify baseline predictors associated with changes in HRQOL assessed using three HRQOL measures. Methods Demographic, disease, medication and HRQOL data were collected at baseline and at 5-year follow-up. HRQOL was assessed using SF-6D, 15D and SF-36. Analyses involved McNemar, independent paired t tests and multiple regression. Results In the 240 (women 31%, men 69%) ax-SpA patients assessed (mean age 46 years), measures reflecting disease activity decreased and co-morbidities increased, and more patients were treated with biologic drugs during follow-up. No deterioration in HRQOL was observed between baseline and 5-year follow-up; indeed, there was a significant increase in SF-6D and SF-36 PCS scores. Improvement in HRQOL measured by SF-6D was associated with younger age, higher education, low Bath Ankylosing Spondylitis (BAS) Activity Index (BASDAI), high BAS Patient Global Score and high C-reactive protein; improvement in SF-36 PCS was associated with younger age, higher education, low BASDAI and no use of biological treatment at baseline. Conclusion Our ax-SpA outpatient clinic patients, with more patients treated with biologic drugs during the 5-year followup, did not deteriorate in HRQOL. In fact, the physical dimension in HRQOL improved over the years, as did measures reflecting disease activity. Our study adds evidence to the importance of suppressing inflammation to maintain and improve HRQOL in ax-SpA patients.

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“…Spearman correlation coefficients were calculated to assess the correlation between ASAS HI and PROs. Candidate variables for regression analysis were referred to the previous studies which investigated associated factors of HRQoL and structural progression in SpA [16,17]. Linear regression analysis was performed to determine predictors of ASAS HI.…”

Section: Methodsmentioning

confidence: 99%

Predictors of Assessment of Spondyloarthritis International Society (ASAS) Health Index in Axial Spondyloarthritis and Comparison of ASAS Health Index between Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis: Data from the Catholic Axial Spondyloarthritis COhort (CASCO)

Min

Lee

Park

et al. 2019

JCM

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The Assessment of Spondyloarthritis International Society (ASAS) health index (HI) is a novel tool for approaching disability, health, and functioning in spondyloarthritis (SpA). In the present study we compared ASAS HI between patients with ankylosing spondylitis (AS) and those with nonradiographic axial SpA (nr-axSpA). In addition, we identified predictors of ASAS HI. We designed this cross-sectional study using data from the Catholic Axial Spondyloarthritis COhort (CASCO), a prospective cohort from a single tertiary hospital. We compared baseline characteristics, including ASAS HI, between AS and nr-axSpA, and determined the frequency of each item constituting the ASAS HI. We used linear regression analysis to identify factors associated with ASAS HI. Total of 357 patients with axSpA—261 with AS and 96 with nr-axSpA—were included in analysis. AS patients were older and had higher ASAS HI than nr-axSpA. Among ASAS HI items, pain (item No. 1) and energy/drive (item No. 5) were the most common areas for which axSpA patients experienced discomfort. ASAS HI correlated with other SpA-related parameters such as BASDAI, ASDAS, and BASFI. Multivariable regression analysis of the axSpA group showed that high NSAID intake and mSASSS were positively associated with ASAS HI, whereas higher economic status and alcohol consumption were negatively associated with ASAS HI. Results were consistent in the AS group on subgroup analysis, whereas alcohol consumption was the only factor significantly associated with ASAS HI in the nr-axSpA group. In the present cohort study, patients with AS had poorer health status (higher ASAS HI) than those with nr-axSpA. Items proposed by AS patients (items No. 1 and 5) were the most frequently checked areas as axSpA patients feel discomfort, and this support that ASAS HI could practically assess actual discomfort of axSpA patient. ASAS HI was well correlated with known disease parameters, including activity, function, and quality of life; therefore, ASAS HI could be used in the future to represent the health status of SpA in a systematic way. Spinal structural damage (higher mSASSS), high NSAID intake, alcohol consumption, and economic status were predictors of ASAS HI in patients with axSpA, especially those with AS.

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Factors related to health-related quality of life in ankylosing spondylitis, overall and stratified by sex

Cited by 61 publications

References 44 publications

Quality of life, pain and anxiety in patients with nephrostomy tubes

Quality of life, pain and anxiety in patients with nephrostomy tubes

No deterioration in health-related quality of life in patients with axial spondyloarthritis followed for 5 years in ordinary outpatient clinics in the biological treatment era

Predictors of Assessment of Spondyloarthritis International Society (ASAS) Health Index in Axial Spondyloarthritis and Comparison of ASAS Health Index between Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis: Data from the Catholic Axial Spondyloarthritis COhort (CASCO)

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