Factors related to diagnostic delay of oral squamous cell carcinoma in southern Thailand: Revisited

Kerdpon, Duangporn; Jantharapattana, Kitti; Sriplung, Hutcha

doi:10.1111/odi.12757

Cited by 17 publications

(28 citation statements)

References 18 publications

(37 reference statements)

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“…Patients with delayed diagnosis have significantly higher probability to present an advanced-stage tumour at diagnosis than patients with no delay in diagnosis similarly to previous studies ( 16 - 18 ). It may be possible that the relationship between delay in diagnosis and advanced oral and oropharyngeal tumour stage is explained by the fact that certain cancers remain silent during the initial stages and produce symptoms only when in advanced phases.…”

Section: Discussionsupporting

confidence: 86%

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The interval since first symptoms until diagnosis of squamous cell carcinoma in the head and neck region is still a problem in southern Brazil

Lb¹,

Rt²,

Lm³

et al. 2020

Med Oral

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Background The aim was to examine the interval since first symptoms until final diagnosis of squamous cell carcinoma (SCC) in the head and neck region in southern Brazil. Material and Methods The individuals were prospectively selected and underwent anamnesis, physical examination and interview in the first medical consultation at a Cancer Hospital from south of Brazil. Results From 488 patients who underwent clinical examination, 105 were included in the study with diagnosis of SCC. Patients average interval from first symptoms to final diagnosis was 152 days (median 86; max:1105; min: 1), the average professional interval was 108 days (median: 97; max:525; min: 1) , and the average total period interval was 258 days (median: 186; max:1177; min: 45). Factors statistically associated with patient and diagnosis itinerary intervals were smoking and poorly adapted dentures and distance from home to hospital, respectively. Conclusions The identification of the itinerary characteristics of this specific population may reflect in more effective public policies, such as primary and secondary prevention programs, aiming to increase the survival of oncological patient. Furthermore, the knowledge of the variables that influence the late diagnosis minimizes patient's journey in search of care to cancer centers through health programs. Key words: Head and neck cancer, time interval, time to diagnosis, diagnosis delay, squamous cell carcinoma.

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Section: Discussionsupporting

confidence: 86%

“…Some studies suggest that approximately 30% of patients with oral cancers seek professional help more than 3 months after presenting first symptoms ( 12 , 18 ). These results are similar to the present study that showed 34% individuals were diagnosed with mouth cancer and 46% for oropharyngeal cancer in that patient interval.…”

Section: Discussionmentioning

confidence: 99%

The interval since first symptoms until diagnosis of squamous cell carcinoma in the head and neck region is still a problem in southern Brazil

Lb¹,

Rt²,

Lm³

et al. 2020

Med Oral

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“…Similarly, rural residence and levels of education were also examined in various studies but the current evidence is insufficient to make any inference. Studies from India, Srilanka, and Thailand (Alahapperuma & Fernando, 2017;Baishya et al, 2015;Kerdpon et al, 2018) found education as a significant factor in determining patient interval but those from USA, England, and Italy cannot establish such links (Guggenheimer et al, 1989;Panzarella et al, 2014;Scott et al, 2008). The stark reflection from this observation is the relevance of education in facilitating health care utilization in developing countries.…”

Section: Discussionmentioning

confidence: 98%

“…An oral cancer-specific review of early diagnosis research also reported similar observations (Varela-Centelles et al, 2018). The mean patient interval duration reported from various countries (Kerdpon, Jantharapattana, & Sriplung, 2018) vary considerably necessitating the need for a region-specific estimate of these durations to assess the need and status of early cancer control initiatives.…”

Section: Discussionmentioning

confidence: 99%

Patient and Diagnostic Intervals in Oral Cancer

Philip

Kannan

2019

ssp

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Background: Oral cancer is an important public health problem in Southeast Asian countries. Generally, cases are reported in advanced stages, resulting in prolonged treatment, high financial burden, and poor prognosis. When diagnosed early, treatment is simple and inexpensive. Materials and Methods: A sequential explanatory study design, cross-sectional survey followed by in-depth interviews, will be used to assess various factors contributing to the patient and diagnostic intervals in oral cancer. At the outset, Data collection tools will be developed and validated. The study protocol is designed as per the "Aarhus statement" for early diagnosis research. In-depth interviews with selected stakeholders and review of documents related to cancer control will constitute the explanatory component of the study design. Discussion: Primary prevention helps in reducing cancer incidence whereas secondary prevention helps in reducing morbidity and mortality. Early diagnosis is a key secondary prevention strategy. Research on early diagnosis of cancer in general and oral cancer, in particular, is scarce. In this regard, a comprehensive and thorough evaluation of various factors facilitates or impede early oral cancer symptom presentation will help in designing policies and programs to promote early diagnosis of oral cancer.

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“…These lesions then become larger and present a higher degrees of invasiveness when the patient finally seeks treatment, confirmed by the more pronounced lesion sizes and higher percentage of tongue SCC metastasis observed herein. Kerdpon et al (2018) indicates that difficulty accessing health services, especially by the most deprived population, also leads to a delay in oral SCC diagnosis and consequently, more advanced development stages, with worse prognosis. It is clear that a broad, free and easily accessible population health system is inversely proportional to the identification of malignant lesions in more advanced stages, including oral SCC, resulting in better patient prognosis.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Lip and Tongue Squamous Cell Carcinoma (Scc) at a Pathological Anatomy Service in Northeast Brazil

Freitas

Maia

Rodrigues

et al. 2021

Int. J. Odontostomat.

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The aim of this work was to trace an epidemiological and clinical profile of oral squamous cell carcinoma (SCC) cases diagnosed as lip and tongue SCC from June 2001 to 2018 at a pathology anatomy service located in Northeastern Brazil. Age, sex, duration, location, growth type, staining, metastasis, etiologic agents and lesion size data were obtained from patient clinical files and histopathological reports. A total of 124 cases were recorded, with tongue SCC being the most prevalent. The common characteristics of both assessed SCCs included higher frequency in men, mean age of 60 years old, evidence mostly of exophytic lesions and maximum size of 4 cm, predominantly diagnosed after a maximum of 1 year of appearance. Regarding divergent findings, lip SCC occurred mostly in the lower portion of the lip, presenting a predominantly leukoplastic color, with regular smoking habits and sunlight identified as the main etiological agents, and no strong relation to metastasis. On the other hand, tongue SCC mostly exhibiting predominantly erythroleukoplastic staining, with a greater relationship to alcoholassociated smoking and regular smoking habits. The highest percentage of patients with metastasis presented tongue SCC. Although lip and tongue SCC display a male preference, an increasing amount of female involvement has been noted over the years, due to the adoption of deleterious habits such as smoking and alcoholism. Tongue SCC presented a greater relationship with metastasis and clinical leukoeritroplastic evidence. This greater aggressiveness could be related to the unfavorable location of these lesions in relation to lip SCC, sometimes making it difficult to identify in their early development stages.

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Factors related to diagnostic delay of oral squamous cell carcinoma in southern Thailand: Revisited

Abstract: Open access to the healthcare system had an influence on diagnostic delay. Public education and precise clinical acumen by HCPs in OSCC diagnosis are needed for early detection.

Cited by 17 publications

References 18 publications

The interval since first symptoms until diagnosis of squamous cell carcinoma in the head and neck region is still a problem in southern Brazil

The interval since first symptoms until diagnosis of squamous cell carcinoma in the head and neck region is still a problem in southern Brazil

Patient and Diagnostic Intervals in Oral Cancer

Prevalence of Lip and Tongue Squamous Cell Carcinoma (Scc) at a Pathological Anatomy Service in Northeast Brazil

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