Factors related to colonic fermentation of nondigestible carbohydrates of a previous evening meal increase tissue glucose uptake and moderate glucose-associated inflammation

Priebe, Marion; Wang, Hong Wei; Weening, Desireé; Schepers, Marianne; Preston, Tom; Vonk, Roel J.

doi:10.3945/ajcn.2009.28521

Cited by 88 publications

(78 citation statements)

References 48 publications

(54 reference statements)

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“…62,63 These changes can persist for hours as was demonstrated in men who ate a fiber rich evening meal and exhibited morning serum butyrate levels comparatively higher compared with those who ate a meal relatively low in fiber. 64 These findings indicate that the concentrations of serum SCFAs are dynamic and fluctuate in response to dietary fiber manipulation. …”

Section: Microbial Scfa Production and Systemic Traffickingmentioning

confidence: 89%

Metabolic tinkering by the gut microbiome

et al. 2014

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Section: Microbial Scfa Production and Systemic Traffickingmentioning

confidence: 89%

Metabolic tinkering by the gut microbiome

et al. 2014

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“…Although there is good observational evidence for whole grains reducing the risk of type 2 diabetes, there is only limited information on the effect of whole grains on glucose metabolism kinetics and insulin response. In a single meal study, whole-grain barley improved peripheral insulin sensitivity as indicated by an increased rate of glucose disappearance (46) . Recent work supports the present hypothesis that whole grains reduce peripheral insulin resistance compared with refined grains (39) , even though no effects on body composition were found in the 8-week study.…”

Section: Branched-chain Amino Acids Aromatic Amino Acids Acyl-carnimentioning

confidence: 99%

Whole grains beyond fibre: what can metabolomics tell us about mechanisms?

Ross

2014

Proc. Nutr. Soc.

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Dietary fibre alone does not fully explain the frequent association between greater intake of whole grains and reduced risk of disease in observational studies, and other phytochemicals or food structure may also play an important role. For all the observational evidence for the benefits of a whole-grain-rich diet, we have only limited knowledge of the mechanisms behind this reduction in disease risk, aside from the action of specific cereal fibres on reduction of blood cholesterol and the post-prandial glucose peak. Nutritional metabolomics, the global measurement and interpretation of metabolic profiles, assesses the interaction of food with the endogenous gene-protein cascade and the gut microbiome. This approach allows the generation of new hypotheses which account for systemic effects, rather than just focusing on one or two mechanisms or metabolic pathways. To date, animal and human trials using metabolomics to investigate mechanistic changes to metabolism on eating whole grains and cereal fractions have led to new hypotheses around mechanistic effects of whole grains. These include the role of cereals as a major source of dietary glycine betaine, a possible effect on phospholipid synthesis or metabolism, the role of branched-chain amino acids and improvements in insulin sensitivity, and the possibility that whole grains may have an effect on protein metabolism. These hypotheses help explain some of the observed effects of whole grains, although mechanistic studies using stable isotopes and fully quantitative measures are required to confirm these potential mechanisms.

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“…barley kernels) reduces plasma glucose levels by nearly 29% in the morning, increases tissue uptake of glucose by 30% and associated with a lower post-prandial circulating IL-6 and TNF-α level. [7] Diabetes is also associated with an increased expression of markers of oxidative stress. For instance patients with diabetes tend to have higher levels of lipid peroxidation than non-diabetics.…”

Section: Diabetes Mellitus and Oxidative Stress In The Gastrointestinalmentioning

confidence: 99%

Diabetes Mellitus and Oxidative Stress in the Gastrointestinal Tract-Connecting the Dots

Chakraborty¹

2011

Free Radicals and Antioxidants

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Factors related to colonic fermentation of nondigestible carbohydrates of a previous evening meal increase tissue glucose uptake and moderate glucose-associated inflammation

Abstract: In healthy subjects, factors related to colonic fermentation of nondigestible carbohydrates increase peripheral insulin sensitivity and moderate glucose-associated inflammation.

Cited by 88 publications

References 48 publications

Metabolic tinkering by the gut microbiome

Metabolic tinkering by the gut microbiome

Whole grains beyond fibre: what can metabolomics tell us about mechanisms?

Diabetes Mellitus and Oxidative Stress in the Gastrointestinal Tract-Connecting the Dots

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