Factors regulating the differences in frequency of infiltration of Th17 and Treg of the blood–brain barrier

Kubick, Norwin; Łazarczyk, Maciej; Strzałkowska, N.; Charuta, Anna; Horbańczuk, J.O.; Sacharczuk, Mariusz; Mickael, Michel‐Edwar

doi:10.1007/s00251-023-01310-y

Cited by 4 publications

(1 citation statement)

References 38 publications

(37 reference statements)

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“…Recent research endeavors have increasingly turned their focus toward the interplay between the immune system and the central nervous system, seeking to uncover novel mechanisms that contribute to the onset and progression of depression. In this emerging landscape, CD4+ T cells, a pivotal component of the adaptive immune response, have come under the spotlight for their potential involvement in mediating neuroinflammatory processes that influence mood and cognition [3] [4] [5]. Simultaneously, Brain-Derived Neurotrophic Factor (BDNF), a versatile neurotrophin with profound roles in synaptic plasticity, mood regulation, and cognitive function, has been recognized as a key player in depression pathogenesis [6].…”

Section: Introductionmentioning

confidence: 99%

The Interaction between CD4+ T Cells and BDNF in Depression and Its Potential Implications for Therapy

Mickael,

Kubick,

Horbańczuk

et al. 2023

Preprint

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Depression is a complex neuropsychiatric disorder characterized by pervasive feelings of sadness, hopelessness, and cognitive impairments that can profoundly impact an individual's quality of life. Despite extensive research efforts, the precise mechanisms underlying depression remain elusive. Recent studies have highlighted the intricate interplay between the immune system and the central nervous system in the pathophysiology of depression. In this context, CD4+ T cells, a key component of the adaptive immune system, have emerged as potential players in the neuroinflammatory processes associated with depression. Concurrently, Brain-Derived Neurotrophic Factor (BDNF), a multifunctional neurotrophin, has garnered significant attention for its roles in neural plasticity, mood regulation, and cognitive function. This review paper explores the intriguing intersection between CD4+ T cells and BDNF in the context of depression and delves into the exciting prospects it offers for therapeutic interventions. By examining the intricate crosstalk between the immune system and the neurotrophic factors, we aim to shed light on the potential avenues for novel therapeutic strategies in the treatment of depression.

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Section: Introductionmentioning

confidence: 99%

The Interaction between CD4+ T Cells and BDNF in Depression and Its Potential Implications for Therapy

Mickael,

Kubick,

Horbańczuk

et al. 2023

Preprint

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The impact of BDNF and CD4 + T cell crosstalk on depression

Mickael,

Kubick,

Dragan

et al. 2024

Immunol Res

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Immunoregulatory Effects of the Active Form of Vitamin D (Calcitriol), Individually and in Combination with Curcumin, on Peripheral Blood Mononuclear Cells (PBMCs) of Multiple Sclerosis (MS) Patients

Fasihi,

Samimi-Badabi,

Robat-Jazi

et al. 2024

AIAAMC

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Objectives: Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease affecting the central nervous system. Immune cell subsets, notably T helper (Th) 17 and Th1, exert important roles in MS pathogenesis. Whereas, Treg cells modulate the disease process. Calcitriol, the active form of vitamin D, and curcumin, a bioactive compound derived from turmeric, play immunomodulatory effects relevant to autoimmune disorders, including MS. The objective of this study is to investigate the effects of calcitriol and Curcumin on Peripheral blood mononuclear cells (PBMCs) of individuals with MS. background: PBMCs from twenty MS patients were isolated, cultured, and exposed to 0.004 μg/mL of calcitriol and 10 μg/mL of curcumin. The cells underwent treatment with singular or combined doses of these components to assess potential cumulative or synergistic immunomod-ulatory effects. Following treatment, the expression levels of genes and the cellular population of Treg, Th1 and Th17 were evaluated using Real-time PCR and flow cytometry. Results: Treatment with curcumin and calcitriol led to a significant reduction in the expression levels of inflammatory cytokines and transcription factors related to Th1 and Th17 cells, includ-ing IFN-γ, T-bet, IL-17, and RORC. Furthermore, the frequency of these cells decreased follow-ing treatment. Additionally, curcumin and calcitriol treatment resulted in a significant upregu-lation of the FOXP3 gene expression and an increase in the frequency of Treg cells. Conclusion: This study demonstrates that curcumin and calcitriol can effectively modulate the inflammatory processes intrinsic to MS by mitigating the expression of inflammatory cytokines by Th1 and Th17 cells while concurrently enhancing the regulatory role of Treg cells. Moreover, the combined treatment of curcumin and calcitriol did not yield superior outcomes compared to single-dosing strategies.

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Factors regulating the differences in frequency of infiltration of Th17 and Treg of the blood–brain barrier

Cited by 4 publications

References 38 publications

The Interaction between CD4+ T Cells and BDNF in Depression and Its Potential Implications for Therapy

The Interaction between CD4+ T Cells and BDNF in Depression and Its Potential Implications for Therapy

The impact of BDNF and CD4 + T cell crosstalk on depression

Immunoregulatory Effects of the Active Form of Vitamin D (Calcitriol), Individually and in Combination with Curcumin, on Peripheral Blood Mononuclear Cells (PBMCs) of Multiple Sclerosis (MS) Patients

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