Factors predictive of positive response to steroid therapy in simple bone cysts: an old trick that still works

Flont, Paweł; Kołacińska-Flont, Marta; Niedzielski, Kryspin

doi:10.1007/s00264-013-1912-7

Cited by 11 publications

(17 citation statements)

References 24 publications

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“…Recent publications have revived this "old trick", with its simplicity, low cost and acceptable success rate. In case of incomplete response to a first injection, treatment is usually repeated once or twice [2,3,12,15,16].…”

Section: Treatmentmentioning

confidence: 99%

Bone cysts: Unicameral and aneurysmal bone cyst

Mascard

Gomez‐Brouchet

Lambot

2015

Orthopaedics & Traumatology: Surgery & Research

231

280

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Simple and aneurysmal bone cysts are benign lytic bone lesions, usually encountered in children and adolescents. Simple bone cyst is a cystic, fluid-filled lesion, which may be unicameral (UBC) or partially separated. UBC can involve all bones, but usually the long bone metaphysis and otherwise primarily the proximal humerus and proximal femur. The classic aneurysmal bone cyst (ABC) is an expansive and hemorrhagic tumor, usually showing characteristic translocation. About 30% of ABCs are secondary, without translocation; they occur in reaction to another, usually benign, bone lesion. ABCs are metaphyseal, excentric, bulging, fluid-filled and multicameral, and may develop in all bones of the skeleton. On MRI, the fluid level is evocative. It is mandatory to distinguish ABC from UBC, as prognosis and treatment are different. UBCs resolve spontaneously between adolescence and adulthood; the main concern is the risk of pathologic fracture. Treatment in non-threatening forms consists in intracystic injection of methylprednisolone. When there is a risk of fracture, especially of the femoral neck, surgery with curettage, filling with bone substitute or graft and osteosynthesis may be required. ABCs are potentially more aggressive, with a risk of bone destruction. Diagnosis must systematically be confirmed by biopsy, identifying soft-tissue parts, as telangiectatic sarcoma can mimic ABC. Intra-lesional sclerotherapy with alcohol is an effective treatment. In spinal ABC and in aggressive lesions with a risk of fracture, surgical treatment should be preferred, possibly after preoperative embolization. The risk of malignant transformation is very low, except in case of radiation therapy.

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Section: Treatmentmentioning

confidence: 99%

Bone cysts: Unicameral and aneurysmal bone cyst

Mascard

Gomez‐Brouchet

Lambot

2015

Orthopaedics & Traumatology: Surgery & Research

231

280

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“…Mean age was 7.8 years (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Eleven cysts (29%) were active and 27 (71%) were latent.…”

Section: Resultsmentioning

confidence: 99%

“…However high recurrence risk after sur-gery and complications linked to surgery were reported (11,12) . To reduce these complications many methods were described (13)(14)(15)(16)(17) . These include injections (steroid, autogenous bone marrow, demineralized bone matrix), multiple drilling and flexible intramedullary nailing (18)(19)(20) .…”

Section: Introductionmentioning

confidence: 99%

Triple methylprednisolone injections for simple humerus cysts at one-month intervals

Çakar¹,

Bülbül²

2018

Okmeydani Medical Journal

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“…The purpose of treatment of SBC is to restore bone strength, cortical thickness, and obliteration of the cyst, as well as to prevent all possible complications, and prolonged restriction of physical activity [1,9,10]. The appropriate treatment, however, remains uncertain, and a wide spectrum of treatment modalities have been proposed ranging from observation to subtotal resection [1].…”

Section: Introductionmentioning

confidence: 99%

Simple Bone Cyst Treated with Percutaneous Steroid Injection

Kamal

Ajiantoro

Prabowo

2018

Asian J Pharm Clin Res

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Objectives: Through this study, we want to explore the effectiveness of methylprednisolone injections to treat simple bone cyst (SBC).Methods: We collected the data of all patients with SBC who were treated with percutaneous steroid injection (PSI). The study was conducted in Cipto Mangunkusumo Hospital and we used a computerized search of operative reports to identify all SBC patients who were treated by PSI 3 times between 2013 and 2016.Results: A total of 10 patients were reported in these serial cases, 8 males and 2 females. The average age of these subjects is 7.8 years old. Musculoskeletal Tumor Society functional score determine good result after 3rd injection of steroid. Bone healing evaluation using Chang Criteria showed a good healing proccess.Conclusion: Steroid injection therapy for SBC yielded a good functional result. It gets solid union relatively quickly, simple operation procedure, widely available, with less side effect. Therefore, this procedure could be a choice for treatment of SBCs patient. Further study needs to be conducted with more sample size.

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Factors predictive of positive response to steroid therapy in simple bone cysts: an old trick that still works

Cited by 11 publications

References 24 publications

Bone cysts: Unicameral and aneurysmal bone cyst

Bone cysts: Unicameral and aneurysmal bone cyst

Triple methylprednisolone injections for simple humerus cysts at one-month intervals

Simple Bone Cyst Treated with Percutaneous Steroid Injection

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