Factors predicting survival in patients with advanced oesophageal cancer: a prospective multicentre evaluation

Bergquist, Henrik; Johnsson, Åse A.; Wenger, Urs; Lundell, Lars; Ruth, Magnus

doi:10.1111/j.1365-2036.2007.03589.x

Cited by 43 publications

(27 citation statements)

References 30 publications

(46 reference statements)

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“…It appears that treatment with radiotherapy alone for elderly patients with esophageal carcinoma is insufficient and there is a need for a more suitable and effective treatment, such as targeted therapy or low-risk chemotherapy. It was confirmed by univariate and multivariate analysis that T, N, M and clinical stage and radiotherapy dose were important prognostic factors for long-term survival, which was consistent with currently available reports (8,9). Of note, we observed that different pathological changes were associated with different survival results.…”

Section: Discussionsupporting

confidence: 79%

Factors affecting long-term survival in elderly patients undergoing radiotherapy for esophageal carcinoma

Liu

Wang

et al. 2014

Molecular and Clinical Oncology

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Abstract. This study was conducted with the aim to analyze the factors affecting the 1-, 3-and 5-year survival rate of elderly patients with esophageal carcinoma. Between 2004 and 2008, a total of 371 patients aged ≥70 years treated with radiotherapy alone were enrolled in this study. The clinical characteristics and radiotherapy dose were evaluated by survival rate and the 1-, 3-and 5-year overall survival (OS) rates were found to be 42, 13.2 and 9.16%, respectively. The univariate analysis revealed significant differences in T, N, M and clinical stage and radiotherapy dose (all P-values <0.05) and no significant differences in gender (all P-values >0.05). There was a difference in tumor location when only comparing the 3-and 5-year OS rates (P=0.031 and P=0.025, respectively). The multivariate analysis identified clinical stage as an independent factor for the 1-year OS rate (P=0.003), whereas radiotherapy dose and clinical stage were found to be independent factors for the 3-and 5-year OS rates (all P-values 0.05). In the analysis of radiotherapy dose, we observed no significant difference in the 1-year OS rate between the radiation dose (DT) >60 Gy and the 50 Gy≤DT<60 Gy groups (P= 0.363); however, there were statistically significant differences in the 3-year OS rate between the 50 Gy≤DT<60 Gy and the other groups (P=0.039 and P= 0.032); there were no significant differences in the 5-year OS rate among the dose groups (all P-values >0.05).In conclusion, according to the findings of this retrospective study, radiotherapy alone for elderly patients with esophageal cancer does not appear to be acceptable and there is a need for a more effective treatment. T, N, M and clinical stage and radiotherapy dose were identified as factors significantly affecting the 1-, 3-and 5-year OS in elderly patients with esophageal carcinoma, although a higher radiotherapy dose with normal fractionation did not appear to improve the OS rate.

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Section: Discussionsupporting

confidence: 79%

Factors affecting long-term survival in elderly patients undergoing radiotherapy for esophageal carcinoma

Liu

Wang

et al. 2014

Molecular and Clinical Oncology

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“…These findings have been corroborated in further published studies. 8,14,29,30 Our study demonstrates that SEMS effectively relieves dysphagia. As a one-off palliative procedure, it is important to have low levels of peri-procedural morbidity and minimal re-interventions to maximise quality of life and minimise re-hospitalisation.…”

Section: Discussionmentioning

confidence: 86%

Fluoroscopically-guided palliative stenting for the management of malignant oesophageal obstruction: A five year experience

Mann

Belgaumkar

Hatrick

et al. 2015

Int J Gastrointest Interv

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A B S T R A C TBackground: Dysphagia is often a sign of advanced malignant oesophageal disease with 90% of these patients requiring palliative intervention. This study aims to evaluate the outcomes of patients treated for malignant obstruction with self-expanding metal stents (SEMS) over a five-year period. Methods: Data was collected retrospectively from patients undergoing SEMS from January 2006 to December 2010. Primary outcomes were operative details, complications, re-interventions, and mortality rates. Results: One hundred twenty procedures were performed on 109 patients without any immediate complications. Thirty-two patients developed early complications and 20 patients died within thirty days. Twelve patients had stent-related difficulties and 10 patients were re-stented for recurrent dysphagia. Median survival from SEMS procedure was 2.7 months with an actuarial survival of 21% at 6 months and 7% at 1 year. Conclusion: SEMS is an effective and safe method of palliation for patients with non-operable oesophageal cancer. Post procedural survival is short and palliative support should be initiated as soon as diagnosis is made.

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“…Radiotherapy and brachytherapy may provide additional survival benefit over stenting, as well as a more sustained improvement in quality of life 3 . However, esophageal stenting remains a widely accepted intervention for those patients too frail for oncological therapies, or in whom dysphagia has progressed despite treatment 4 .…”

Section: Introductionmentioning

confidence: 99%

The Glasgow Prognostic Score at the Time of Palliative Esophageal Stent Insertion is a Predictive Factor of 30-Day Mortality and Overall Survival

Driver¹,

Handforth

Radhakrishna

et al. 2018

Journal of Clinical Gastroenterology

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Factors predicting survival in patients with advanced oesophageal cancer: a prospective multicentre evaluation

Abstract: SUMMARY BackgroundOesophageal cancer is often diagnosed at an advanced stage, with poor prognosis and severe morbidity. In majority of cases, palliative treatment is the only option available.

Cited by 43 publications

References 30 publications

Factors affecting long-term survival in elderly patients undergoing radiotherapy for esophageal carcinoma

Factors affecting long-term survival in elderly patients undergoing radiotherapy for esophageal carcinoma

Fluoroscopically-guided palliative stenting for the management of malignant oesophageal obstruction: A five year experience

The Glasgow Prognostic Score at the Time of Palliative Esophageal Stent Insertion is a Predictive Factor of 30-Day Mortality and Overall Survival

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