Factors predicting successful induction of oocyte maturation after gonadotropin releasing hormone agonist (GnRH) trigger

Kummer, Nicole; Mann, J.S.; Elassar, A.A.; Nulsen, John; Benadiva, Claudio; Engmann, Lawrence

doi:10.1016/j.fertnstert.2010.07.947

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With a shorter duration of LH surge of about 34 hrs, it mimics the natural cycle surge duration of 48 hrs and thereby reducing the risk of OHSS in high responders [5,6,7] . However, there was increased risk of empty follicle syndrome following isolated GnRH agonist trigger due to suboptimal surge of LH [8] . In cases of poor response to GnRH agonist which is seen in about 2.71% of the study population in the respective studies, the HCG injection of the dual trigger could act as a safeguard against empty follicular syndrome [9,10] .…”

Section: Introductionmentioning

confidence: 99%

A retrospective observational study to see the effect of dual trigger on IVF outcomes in poor ovarian responders

Bakshi¹,

Khaitan²,

Singh³

et al. 2022

Int. J. Clin. Obstet. Gynaecol.

View full text Add to dashboard Cite

Background: Poor Responders Patients undergoing IVF treatment were given Dual Trigger for final oocyte maturation. Poor responders are the patients in whom, less number of egg were retrieved. Typically, they were with advanced maternal age and poor ovarian reserve (AFC <5-7 follicle or AMH < 1.2ng/ml) or with a history of previous Poor ovarian reserve (<3 oocytes) with Controlled ovarian stimulation. This study aimed to examine the effectiveness of dual trigger for final oocyte maturation in poor responder patients based on Bologna criteria (2011). Methods: A total of 30 IVF cycles of poor responder patients were retrospectively analyzed. The study group (15 patients) was given dual triggers (HCG and GnRH agonist) for final oocyte maturation whereas in control group final oocyte maturation was performed with HCG only. GnRH antagonist Protocol was used in both the groups. Baseline characteristics, number of oocyte retrieved, the number of M-2 and the quality of embryo of both groups were compared. Results: Both the groups were comparable in baseline characteristics. In our study, there was not much difference in number of oocyte retrieved, but there was higher number of M2 and top quality embryo, compared to control group. Conclusion: Dual trigger might be a superior option for final oocyte maturation as compared to hCG trigger alone in terms of IVF cycles outcomes in poor responders and further large scale randomized prospective studies needed to validate our results.

show abstract