Factors of Risk in the Development of Coronary Heart Disease—Six-Year Follow-up Experience

Kannel, William B.; Dawber, Thomas R.; Kagan, Abraham; Revotskie, Nicholas; Stokes, Joseph

doi:10.7326/0003-4819-55-1-33

Cited by 1,495 publications

(346 citation statements)

References 8 publications

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“…The now-ubiquitous concept of the coronary 'risk factor' originated with the FHS [48]. But while such risk factors have overwhelmingly measured proximate behavioural and biological markers, research on the social determinants of health has identified persistent effects of socioeconomic processes difficult to reconcile with a biomedical approach.…”

Section: Discussionmentioning

confidence: 99%

Social connectedness is associated with fibrinogen level in a human social network

et al. 2016

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Socially isolated individuals face elevated rates of illness and death. Conventional measures of social connectedness reflect an individual's perceived network and can be subject to bias and variation in reporting. In this study of a large human social network, we find that greater indegree, a sociocentric measure of friendship and familial ties identified by a subject's social connections rather than by the subject, predicts significantly lower concentrations of fibrinogen (a biomarker of inflammation and cardiac risk), after adjusting for demographics, education, medical history and known predictors of cardiac risk. The association between fibrinogen and social isolation, as measured by low indegree, is comparable to the effect of smoking, and greater than that of low education, a conventional measure of socioeconomic disadvantage. By contrast, outdegree, which reflects an individual's perceived connectedness, displays a significantly weaker association with fibrinogen concentrations.

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Section: Discussionmentioning

confidence: 99%

Social connectedness is associated with fibrinogen level in a human social network

et al. 2016

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“…Although progress in cardiovascular medicine has substantially reduced the death toll in the past decades, deeper insight into the pathophysiology of atherosclerosis is mandatory to further improve strategies for the prevention and treatment. Epidemiological studies, especially the Framingham Heart Study, spearheaded the efforts to track down the causes for myocardial infarction (MI) and led to the identification of several predictors for CAD, for example hypertension and hypercholesterolaemia (Kannel et al , 1961) which, together with obesity, smoking and diabetes, are condensed under the term “modifiable risk factors”, as they can be addressed by lifestyle changes and therapeutic interventions (Yusuf et al , 2004). …”

Section: Introductionmentioning

confidence: 99%

The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease

2016

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Cardiovascular diseases are leading causes for death worldwide. Genetic disposition jointly with traditional risk factors precipitates their manifestation. Whereas the implications of a positive family history for individual risk have been known for a long time, only in the past few years have genome‐wide association studies (GWAS) shed light on the underlying genetic variations. Here, we review these studies designed to increase our understanding of the pathophysiology of cardiovascular diseases, particularly coronary artery disease and myocardial infarction. We focus on the newly established pathways to exemplify the translation from the identification of risk‐related genetic variants to new preventive and therapeutic strategies for cardiovascular disease.

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“…Cardiovascular risk scales have been developed from Western cohorts such as the Framingham study [18] or the SCORE project [19]. The performances of these scales could vary, depending on the source population [20–22]; adaptations of Framingham scales for other populations were proposed by some authors in Europe [23,24].…”

Section: Introductionmentioning

confidence: 99%

Feasibility of a cardiovascular cohort in a Sub-Saharan Africa community: preliminary report of the pilot project TAHES (Tanvè Health Study) in Benin

Houehanou

Mizéhoun-Adissoda

Amidou

et al. 2017

Global Health Action

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Background: Faced with the growing burden of cardiovascular disease (CVD) including atherosclerotic in Sub-Saharan Africa (SSA), the development of appropriate prediction tools, based on large cohorts, appears useful for prevention. Objective: The objective of the pilot project TAHES (Tanvè Health Study) was to explore the feasibility of a large cohort study focused on CVD and risk factors in Benin. Methods: We implemented a prospective cohort over 2 years. The sample consisted of all people aged 25 years or older who had lived for at least the previous 6 months in the villages of Tanvè or Dékanmè. At baseline in February 2015, behaviours and medical histories were recorded using a standardized questionnaire adapted from the WHO Steps instrument; screening questionnaires for angina, claudication, congestive heart failure, and stroke were applied; anthropometric measures and fasting capillary blood glucose were taken. All participants were included in the follow-up phase. Surveillance of target CVD and deaths was implemented through a medical and a community network. Results: A total of 1,195 participants were enrolled at baseline; women represented 65.5% and the median age was 39 years. The high participation rate (91.4%), the quality of baseline data, and the functionality of the events surveillance network over 8 months indicated good perspective for the feasibility of a large cohort. We recorded a 3.8% prevalence of daily smoking, 3.6% of harmful use of alcohol, 10.7% of obesity, 25.5% of high blood pressure, and 3.5% of diabetes. Prevalence of angina pectoris (2.7%), intermittent claudication (2.0%), congestive heart failure (0.9%), and stroke survival with motor impairment (3‰) were also recorded. Ten deaths occurred during the first 8 months, all within households; a cardiovascular cause was suspected in four cases. Conclusion: These preliminary results support the feasibility of establishing a cohort in Benin. It would require technical and resource support.

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Factors of Risk in the Development of Coronary Heart Disease—Six-Year Follow-up Experience

Cited by 1,495 publications

References 8 publications

Social connectedness is associated with fibrinogen level in a human social network

Social connectedness is associated with fibrinogen level in a human social network

The impact of genome‐wide association studies on the pathophysiology and therapy of cardiovascular disease

Feasibility of a cardiovascular cohort in a Sub-Saharan Africa community: preliminary report of the pilot project TAHES (Tanvè Health Study) in Benin

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