Factors modulating the incubation of drug and non-drug craving and their clinical implications

Vènniro, Marco; Reverte, Ingrid; Ramsey, Leslie A.; Papastrat, Kimberly M.; D’Ottavio, Ginevra; Milella, Michele Stanislaw; Li, Xuan; Grimm, Jeffrey W.; Caprioli, Daniele

doi:10.1016/j.neubiorev.2021.09.050

Cited by 33 publications

(23 citation statements)

References 291 publications

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“…For example, negative experiences such as bullying, social conflict, and economic stress are found to be common triggers of drug relapse. On the other hand, positive social experiences, such as having friends and social support, can be restorative factors over relapse [22][23][24][25]. Therefore, it is not surprising that therapies that improve the adolescents' most important social environments -their families -are found to be helpful in the treatment of SUDs.…”

Section: New Ideas In Sud Prevention and Treatmentmentioning

confidence: 99%

Preventing Substance Abuse in Adolescents: A Review of High-Impact Strategies

Hsiung¹,

Patel²,

Hundal³

et al. 2022

Cureus

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Substance abuse has been an intractable societal concern in the US for more than half a century. The recent opioid epidemic has only accentuated this problem. Adolescents are significant long-term contributors to the crisis due to their susceptibilities to drug abuse and impressionable age. This review examines the particular vulnerabilities of the adolescent brain to drug abuse and the risk and protective factors thereof, especially in light of the Rat Park studies. In addition, the article provides an overview of the evidence-based prevention program registries and offers detailed summaries of two: Blueprints for Healthy Youth Development (Blueprints) and the Washington State Institute for Public Policy (WSIPP). By combining inputs from Blueprints and WSIPP, five programs with the highest benefit-cost ratios (BCR) were identified: Functional Family Therapy, Positive Family Support, Lifeskills Training, Positive Action, and Good Behavior Game. In light of their outstanding characteristics, these programs are poised to be widely implemented and to make a measurable difference in the fight against substance and opioid abuse.

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Section: New Ideas In Sud Prevention and Treatmentmentioning

confidence: 99%

Preventing Substance Abuse in Adolescents: A Review of High-Impact Strategies

Hsiung¹,

Patel²,

Hundal³

et al. 2022

Cureus

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“…Thus, in the present study, we first compared continuous‐ and intermittent‐access heroin self‐administration in male and female rats and modelled the brain concentration of heroin and its active metabolites, 6‐monoacetylmorphine (6‐MAM) and morphine (Inturrisi et al, 1983), based on available drug kinetics data (Gottas et al, 2013). We then assessed the impact of these distinct self‐administration procedures on relapse to drug‐seeking after two different abstinence conditions, forced and choice‐based voluntary abstinence (Caprioli, Venniro, et al, 2015; Venniro et al, 2020; Venniro et al, 2021; Venniro, Zhang, et al, 2017). The forced abstinence procedure resembles the human condition typically occurring during hospitalization or incarceration.…”

Section: Introductionmentioning

confidence: 99%

Increased heroin intake and relapse vulnerability in intermittent relative to continuous self‐administration: Sex differences in rats

D’Ottavio

Reverte

Ragozzino

et al. 2022

British J Pharmacology

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Background and Purpose Studies using intermittent‐access drug self‐administration show increased motivation to take and seek cocaine and fentanyl, relative to continuous access. In this study, we examined the effects of intermittent‐ and continuous‐access self‐administration on heroin intake, patterns of self‐administration and cue‐induced heroin‐seeking, after forced or voluntary abstinence, in male and female rats. We also modelled brain levels of heroin and its active metabolites. Experimental Approach Rats were trained to self‐administer a palatable solution and then heroin (0.075 mg·kg−1 per inf) either continuously (6 h·day−1; 10 days) or intermittently (6 h·day−1; 5‐min access every 30‐min; 10 days). Brain levels of heroin and its metabolites were modelled using a pharmacokinetic software. Next, heroin‐seeking was assessed after 1 or 21 abstinence days. Between tests, rats underwent either forced or voluntary abstinence. The oestrous cycle was measured using a vaginal smear test. Key Results Intermittent access exacerbated heroin self‐administration and was characterized by a burst‐like intake, yielding higher brain peaks of heroin and 6‐monoacetylmorphine concentrations. Moreover, intermittent access increased cue‐induced heroin‐seeking during early, but not late abstinence. Heroin‐seeking was higher in females after intermittent, but not continuous access, and this effect was independent of the oestrous cycle. Conclusions and Implications Intermittent heroin access in rats resembles critical features of heroin use disorder: a self‐administration pattern characterized by repeated large doses of heroin and higher relapse vulnerability during early abstinence. This has significant implications for refining animal models of substance use disorder and for better understanding of the neuroadaptations responsible for this disorder. LINKED ARTICLES This article is part of a themed issue on Advances in Opioid Pharmacology at the Time of the Opioid Epidemic. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v180.7/issuetoc

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“…Studies have shown an abstinence-dependent increase in cocaine craving for humans (4), later supported in rodents, as an increase in operant responding over time for cocaine cues ("incubation of craving") (5). Incubation of craving has now been observed across several drug classes and foods (for a thorough analysis on incubation of craving, we refer the readers to the following reviews: Grimm (6) and Venniro et al (7)). Therefore, incubation of craving may contribute to an individual's inability to maintain a healthy diet plan.…”

Section: Introductionmentioning

confidence: 99%

“…In clinical trials, exercise decreased cannabis, alcohol, and nicotine craving (7) and reduced heightened neural activity to food images (8). Exercise is correlated with a reduction in preference for high-fat food and it may reduce food reward (both liking and wanting) to curb hedonic eating (9).…”

Section: Introductionmentioning

confidence: 99%

Acute high‐intensity interval exercise attenuates incubation of craving for foods high in fat

Kirkpatrick

Dingess

Aadland

et al. 2022

Obesity

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Objective: Food-seeking behaviors can be driven by food-associated cues, and palatable food seeking in response to food cues is a risk factor for obesity development.Cue-induced food seeking increases following a period of abstinence, a behavioral phenomenon known as "incubation of craving," which may contribute to an individual's difficulty abstaining from palatable foods. Pharmacological and environmental manipulations have been employed to try and reduce incubation of craving, albeit primarily in drug abuse paradigms. The goal of this study was to determine whether forced exercise can attenuate incubation of high-fat food craving.Methods: Male Sprague Dawley rats learned to self-administer high-fat pellets (60%) in combination with a compound cue (light + tone). The influence of high-intensity interval exercise on the time-dependent increase in cue-induced lever responding was investigated 30 days after the first cue test.Results: Rats exposed to exercise during abstinence did not express incubation of craving. Conclusions:The results suggest that high-intensity exercise can prevent the establishment of incubation of craving for foods high in fat and may reduce cue-induced maladaptive food-seeking behaviors that contribute to overeating and obesity.How to cite this article: Kirkpatrick GE, Dingess PM, Aadland JA, Brown TE. Acute high-intensity interval exercise attenuates incubation of craving for foods high in fat. Obesity

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Factors modulating the incubation of drug and non-drug craving and their clinical implications

Cited by 33 publications

References 291 publications

Preventing Substance Abuse in Adolescents: A Review of High-Impact Strategies

Preventing Substance Abuse in Adolescents: A Review of High-Impact Strategies

Increased heroin intake and relapse vulnerability in intermittent relative to continuous self‐administration: Sex differences in rats

Acute high‐intensity interval exercise attenuates incubation of craving for foods high in fat

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