Factors modulating neural reactivity to drug cues in addiction: A survey of human neuroimaging studies

Jasinska, Agnes J.; Stein, Elliot A.; Kaiser, Jochen; Naumer, Marcus J.; Yalachkov, Yavor

doi:10.1016/j.neubiorev.2013.10.013

Cited by 451 publications

(435 citation statements)

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“…And activation of the dorsal striatum resulted in activation in the insula, which subsequently influenced prefrontal ROIs. The involvement of dorsal striatum in this pathway is important as it has been long implicated in chronic drug use in both human and animal studies (Jasinska et al, 2014;Vollstädt-Klein et al, 2010b). To propose a theoretical model based on our results, we speculate that the early stage of drug-cue processing may reflect activation of the cocaine users' long-term memory of drug cues and contexts (Jasinska et al, 2014;Spaniol et al, 2009;Tiffany, 1990;Volkow et al, 2002), consistent with the activation of amygdala and hippocampus and the causal influence of amygdala on hippocampus.…”

Section: Discussionsupporting

confidence: 72%

“…As hippocampus and parahippocampal gyrus are a part of the hippocampal complex (Nadel et al, 2003), and activation in both of these regions has been reported in earlier drug cue reactivity studies (Charboneau et al, 2013;Janes et al, 2010b;Langleben et al, 2008), we decided to include the parahippocampal gyrus ((right; anterior division); Figure 1j) as one of the ROIs in our analysis. Altogether, these 10 ROIs encompass the major areas of the brain's mesocorticolimbic and nigrostriatal systems (Jasinska et al, 2014). For bilateral activation, the mean voxel-based time series for the right brain area (for example, right amygdala) and the left brain area (for example, left amygdala) were averaged to create the mean voxel-based time series for that brain area (amygdala).…”

Section: Imaging Resultsmentioning

confidence: 99%

“…of decision making/craving/motivated behavior related to continued drug use (Balleine et al, 2007;Jasinska et al, 2014). This theoretical model incorporates the considerable overlap between certain regions within the long-term memory network and the drug-cue processing network (Jasinska et al, 2014;Spaniol et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…This theoretical model incorporates the considerable overlap between certain regions within the long-term memory network and the drug-cue processing network (Jasinska et al, 2014;Spaniol et al, 2009). The present study extends the previous research by establishing for the first time that exposure to cocaine cues initiates a causal interaction between the ROIs within the drug-cue processing network, which is a component of the brain's mesocorticolimbic and nigrostriatal systems.…”

Section: Discussionmentioning

confidence: 99%

“…Neuroimaging studies demonstrate that the areas activated by exposure to drug cues in chronic drug users include the prefrontal cortex (medial prefrontal cortex, orbital frontal cortex, dorsolateral prefrontal cortex), ventral tegmental area, anterior cingulate cortex, insula, striatum, amygdala, and hippocampus (see Jasinska et al, 2014 for a review). These areas comprise the mesocorticolimbic system of the brain, which is implicated in reward, motivation, and goal-directed behavior.…”

Section: Introductionmentioning

confidence: 99%

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Modeling Causal Relationship Between Brain Regions Within the Drug-Cue Processing Network in Chronic Cocaine Smokers

Ray

Haney

Hanson

et al. 2015

Neuropsychopharmacol

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The cues associated with drugs of abuse have an essential role in perpetuating problematic use, yet effective connectivity or the causal interaction between brain regions mediating the processing of drug cues has not been defined. The aim of this fMRI study was to model the causal interaction between brain regions within the drug-cue processing network in chronic cocaine smokers and matched control participants during a cocaine-cue exposure task. Specifically, cocaine-smoking (15M; 5F) and healthy control (13M; 4F) participants viewed cocaine and neutral cues while in the scanner (a Siemens 3 T magnet). We examined whole brain activation, including activation related to drug-cue processing. Time series data extracted from ROIs determined through our General Linear Model (GLM) analysis and prior publications were used as input to IMaGES, a computationally powerful Bayesian search algorithm. During cocaine-cue exposure, cocaine users showed a particular feed-forward effective connectivity pattern between the ROIs of the drug-cue processing network (amygdala → hippocampus → dorsal striatum → insula → medial frontal cortex, dorsolateral prefrontal cortex, anterior cingulate cortex) that was not present when the controls viewed the cocaine cues. Cocaine craving ratings positively correlated with the strength of the causal influence of the insula on the dorsolateral prefrontal cortex in cocaine users. This study is the first demonstration of a causal interaction between ROIs within the drug-cue processing network in cocaine users. This study provides insight into the mechanism underlying continued substance use and has implications for monitoring treatment response.

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Section: Discussionsupporting

confidence: 72%

Section: Imaging Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Modeling Causal Relationship Between Brain Regions Within the Drug-Cue Processing Network in Chronic Cocaine Smokers

Ray

Haney

Hanson

et al. 2015

Neuropsychopharmacol

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Impaired Functional Connectivity Within and Between Frontostriatal Circuits and Its Association With Compulsive Drug Use and Trait Impulsivity in Cocaine Addiction

et al. 2015

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IMPORTANCE Converging evidence has long identified both impulsivity and compulsivity as key psychological constructs in drug addiction. Although dysregulated striatal-cortical network interactions have been identified in cocaine addiction, the association between these brain networks and addiction is poorly understood. OBJECTIVES To test the hypothesis that cocaine addiction is associated with disturbances in striatal-cortical communication as captured by resting-state functional connectivity (rsFC), measured from coherent spontaneous fluctuations in the blood oxygenation level-dependent functional magnetic resonance imaging signal, and to explore the relationships between striatal rsFC, trait impulsivity, and uncontrolled drug use in cocaine addiction. DESIGN, SETTING, AND PARTICIPANTS A case-control, cross-sectional study was conducted at the National Institute on Drug Abuse Intramural Research Program outpatient magnetic resonance imaging facility. Data used in the present study were collected between December 8, 2005, and September 30, 2011. Participants included 56 non-treatment-seeking cocaine users (CUs) (52 with cocaine dependence and 3 with cocaine abuse) and 56 healthy individuals serving as controls (HCs) matched on age, sex, years of education, race, estimated intelligence, and smoking status. MAIN OUTCOMES AND MEASURES Voxelwise statistical parametric analysis testing the rsFC strength differences between CUs and HCs in brain regions functionally connected to 6 striatal subregions defined a priori. RESULTS Increased rsFC strength was observed predominantly in striatal-frontal circuits; decreased rsFC was found between the striatum and cingulate, striatal, temporal, hippocampal/amygdalar, and insular regions in the CU group compared with the HCs. Increased striatal-dorsal lateral prefrontal cortex connectivity strength was positively correlated with the amount of recent cocaine use (uncorrected P < .046) and elevated trait impulsivity in the CUs (uncorrected P < .012), and an index reflecting the balance between striatal-dorsal anterior cingulate cortex and striatal-anterior prefrontal/orbitofrontal cortex circuits was significantly associated with loss of control over cocaine use (corrected P < .012). CONCLUSIONS AND RELEVANCE Cocaine addiction is associated with disturbed rsFC in several specific striatal-cortical circuits. Specifically, compulsive cocaine use, a defining characteristic of dependence, was associated with a balance of increased striatal-anterior prefrontal/orbitofrontal and decreased striatal-dorsal anterior cingulate connectivity; trait impulsivity, both a risk factor for and a consequence of cocaine use, was associated with increased dorsal striatal-dorsal lateral prefrontal cortex connectivity uniquely in CUs. These findings provide new insights toward the neurobiological mechanisms of addiction and suggest potential novel therapeutic targets for treatment.

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Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving

et al. 2017

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IMPORTANCE A relapse into nicotine addiction during abstinence often occurs after the reactivation of nicotine reward memories, either by acute exposure to nicotine (a smoking episode) or by smoking-associated conditioned stimuli (CS). Preclinical studies suggest that drug reward memories can undergo memory reconsolidation after being reactivated, during which they can be weakened or erased by pharmacological or behavioral manipulations. However, translational clinical studies using CS-induced memory retrieval-reconsolidation procedures to decrease drug craving reported inconsistent results. OBJECTIVE To develop and test an unconditioned stimulus (UCS)-induced retrieval-reconsolidation procedure to decrease nicotine craving among people who smoke. DESIGN, SETTING, AND PARTICIPANTS A translational rat study and human study in an academic outpatient medical center among 96 male smokers (aged 18–45 years) to determine the association of propranolol administration within the time window of memory reconsolidation (after retrieval of the nicotine-associated memories by nicotine UCS exposure) with relapse to nicotine-conditioned place preference (CPP) and operant nicotine seeking in rats, and measures of preference to nicotine-associated CS and nicotine craving among people who smoke. INTERVENTION The study rats were injected noncontingently with the UCS (nicotine 0.15 mg/kg, subcutaneous) in their home cage, and the human study participants administered a dose of propranolol (40 mg, per os; Zhongnuo Pharma). MAIN OUTCOMES AND MEASURES Nicotine CPP and operant nicotine seeking in rats, and preference and craving ratings for newly learned and preexisting real-life nicotine-associated CS among people who smoke. RESULTS Sixty-nine male smokers completed the experiment and were included for statistical analysis: 24 in the group that received placebo plus 1 hour plus UCS, 23 who received propranolol plus 1 hour plus UCS, and 22 who received UCS plus 6 hours plus propranolol. In rat relapse models, propranolol injections administered immediately after nicotine UCS-induced memory retrieval inhibited subsequent nicotine CPP and operant nicotine seeking after short (CPP, d = 1.72, 95% CI, 0.63–2.77; operant seeking, d = 1.61, 95% CI, 0.59–2.60) or prolonged abstinence (CPP, d = 1.46, 95% CI, 0.42–2.47; operant seeking: d = 1.69, 95% CI, 0.66–2.69), as well as nicotine priming-induced reinstatement of nicotine CPP (d = 1.28, 95% CI, 0.27–2.26) and operant nicotine seeking (d = 1.61, 95% CI, 0.59–2.60) after extinction. Among the smokers, oral propranolol administered prior to nicotine UCS-induced memory retrieval decreased subsequent nicotine preference induced by newly learned nicotine CS (CS1, Cohen d =0.61, 95% CI, 0.02–1.19 and CS2, d = 0.69, 95% CI, 0.10–1.28, respectively), preexisting nicotine CS (d = 0.57, 95% CI, −0.02 to 1.15), and nicotine priming (CS1, d = 0.82, 95% CI, 0.22–1.41 and CS2, d = 0.78, 95% CI, 0.18–1.37, respectively; preexisting nicotine CS, d = 0.92, 95% CI, 0.31–1.52), as well as nicotine c...

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Factors modulating neural reactivity to drug cues in addiction: A survey of human neuroimaging studies

Cited by 451 publications

References 154 publications

Modeling Causal Relationship Between Brain Regions Within the Drug-Cue Processing Network in Chronic Cocaine Smokers

Modeling Causal Relationship Between Brain Regions Within the Drug-Cue Processing Network in Chronic Cocaine Smokers

Impaired Functional Connectivity Within and Between Frontostriatal Circuits and Its Association With Compulsive Drug Use and Trait Impulsivity in Cocaine Addiction

Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving

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