Factors Involved in Endothelial Dysfunction Related to Angiogenic Disbalance and Oxidative Stress, in Women at High Risk of Term Pre-Eclampsia

Abstract

Oxidative and inflammatory stress, angiogenic imbalance, and endothelial dysfunction are pathophysiological mechanisms occurring in pre-eclampsia (PE) that may persist over time and predispose women to a higher risk of cardiovascular disease (CVD) in the future. However, there is little evidence on the vascular function of women at risk of PE who have not developed the disease. The main objective of this research is to study factors and biomarkers involved in endothelial dysfunction related to oxidative stress, angiogenic disbalance, and inflammation in women at high risk of term PE who do not develop the disease. An observational, analytical, retrospective, and descriptive study was carried out in a selected sample of 68 high-risk and 57 non-risk of term PE participants in the STATIN study (FFIS/2016/02/ST EUDRACT No: 2016-005206-19). A significant increase in mean arterial pressure (MAP) levels and oxidative stress biomarkers (uric acid, homocysteine, and total serum antioxidant capacity) was found. Biomarkers of inflammation (interleukin-6 and growth differentiation factor 15) and endothelial function (asymmetric dimethylarginine) were significantly elevated in the group at risk of pre-eclampsia. A significative dependence relationship was also established between MAP and interleukin-6 and uric acid. These results suggest that women at high risk of term PE may represent pregnancies with pre-existing maternal risk factors for CVD, manifested by the own cardiovascular overload of pregnancy. A better understanding of maternal cardiovascular function in pregnancy would allow the improved prediction of CVD late in life in women.

lncRNA NEAT1/miR‐495‐3p regulates angiogenesis in burn sepsis through the TGF‐β1 and SMAD signaling pathways

“…Under normal conditions, the endothelium regulates vascular homeostasis by maintaining blood fluidity, nutrient trafficking, vasomotor tone, angiogenesis, and other processes 23 . The pathological process leading to endothelial cell dysfunction is very complex, including oxidative stress, angiogenic growth factor imbalance, vascular tone regulator molecules, and other factors 24 . Sepsis can alter endothelial permeability and the vasomotor response.…”

“… 23 The pathological process leading to endothelial cell dysfunction is very complex, including oxidative stress, angiogenic growth factor imbalance, vascular tone regulator molecules, and other factors. 24 Sepsis can alter endothelial permeability and the vasomotor response. These changes have been observed in animal models of sepsis as well as in human tissues.…”

Association between leucocyte telomere length and erectile dysfunction in US adults: a secondary study based on 2001–2002 NHANES data

“…Multiple mechanisms may contribute to ED, and numerous studies have reported risk factors for the occurrence and development of ED 6. Endothelial dysfunction, a major cause of ED, is thought to be associated with inflammatory and oxidative stress levels 7. Many vascular endothelial damage-associated diseases, such as cardiovascular disease (CVD)8 and type 2 diabetes, share this common pathological mechanism with ED 9.…”

“… 6 Endothelial dysfunction, a major cause of ED, is thought to be associated with inflammatory and oxidative stress levels. 7 Many vascular endothelial damage-associated diseases, such as cardiovascular disease (CVD) 8 and type 2 diabetes, share this common pathological mechanism with ED. 9 Therefore, ED is a harbinger of the severe development of these diseases.…”

Uric acid/superoxide dismutase can predict progression of gestational hypertension to preeclampsia

“…Moreover, superoxide dismutase (SOD) is an important antioxidant that protects tissue from oxidative damage and can protect blood vessels from ROS damage and maintain vascular function ( 14 ). SOD is significantly decreased in endothelial cell injury diseases ( 15 , 16 ). A meta-analysis of 2,953 PE pregnant women and 3,621 healthy pregnant women found that a total of 26 studies described the SOD level of 739 PE pregnant women and 906 healthy pregnant women.…”