Factors Influencing Weight Gain After Renal Transplantation

Johnson, Christopher P.; Gallagher-Lepak, Susan; Zhu, Yong-Ran; Porth, Carol M.; Kelber, Sheryl T.; Roza, Allan M.; Adams, Mark B.

doi:10.1097/00007890-199310000-00008

Cited by 151 publications

(120 citation statements)

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“…O ganho excessivo de peso após o transplante renal está relacionado a vários fatores, entre eles idade, sexo, raça, história familiar, nível educacional, além da terapia imunossupressora (10) . A frequência de DMPT encontrada neste estudo foi de 1,4%, estando de acordo com a literatura.…”

Section: Discussionunclassified

Fatores de risco cardiovascular em pacientes pediátricos após um ano de transplante renal

et al. 2010

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. Results: A half of patients (50.5%) used high blood pressure medications prior to undergoing renal transplant. A year after renal transplant the use of high blood pressure medications by the pediatric patients was reduced by 28%. Before transplant, 13.5% of the patients were overweighed and did not have any significant changes in their weight after the transplant (12.6%). There was an increase in the number of overweight patients after a year of renal transplant by 50.0%. Approximately 1.0% of the patients developed diabetes mellitus after the renal transplant. Conclusion: Obesity, high blood pressure, and diabetes mellitus were common conditions among pediatric patients after renal transplant.

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Section: Discussionunclassified

Fatores de risco cardiovascular em pacientes pediátricos após um ano de transplante renal

et al. 2010

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“…The average weight gain during the 1st year after transplantation is approximately 10 %; thereafter, women especially are prone to gain more weight (up to 20 % in 5 years) [5]. This increase induces changes in lipid metabolism that may be significant in terms of altering the risk of cardiovascular morbidity [5,6,8], which has been found to be the most common cause of patient death after renal transplantation. Another significant risk factor in overweight recipients after renal transplantation is the development of insulin-dependent diabetes [2,4].…”

Section: Discussionmentioning

confidence: 99%

“…Another significant risk factor in overweight recipients after renal transplantation is the development of insulin-dependent diabetes [2,4]. In recipients with a BMI greater than or equal to 30 before transplantation, the weight gain may have more serious consequences, even if the amount of weight gained has not been found to correlate with preexisting obesity [5].…”

Section: Discussionmentioning

confidence: 99%

Is obesity still a risk factor in renal transplantation?

Halme¹,

Eklund²,

Kyllönen³

et al. 1997

Transplant International

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At our center, since 1982, a body mass index (BMI) of less than 30 has been a prerequisite for placing a patient on the waiting list for renal transplantation. This decision was made because obese transplant recipients seemed to have a less than favorable post-transplant outcome. The aim of this study was to evaluate whether this requirement is still justified. Forty-six patients with a BMI above 30 underwent primary cadaveric renal transplantation between 1972 and 1993. For each of these obese patients, five consecutive nonobese (BMI 20-25) control patients were selected. Patient and graft survival, causes of graft loss, and acute rejection rate were evaluated for the two patient groups before and after the year 1982. Within the first 30 post-transplant days, one patient (2 Yo) and 11 grafts (24 Yo) were lost in the group of obese patients whereas seven patients (3 %) and 36 grafts (16 YO) were lost in the control group. Among the obese patients, renal circulatory complications were a major cause of graft loss. In the period 1973-1 981, the 1 -year patient survival rate was 65 O/O among obese patients versus 75 YO among controls from 1982 to 1993, this was 90 Yo versus 93 %. From 1973 to 1981, the 1-year graft survival rate was 25 YO among obese patients versus 53 YO among controls ( P < 0.05); from 1982 to 1993, it was 68 YO versus 84 YO ( P = NS). Multivariate analysis showed that the immunosuppressive regimen, age of the patient, BMI, and cold ischemia time of the graft had a significant influence on graft survival. The acute rejection rate within the first 30 days was 28 YO among obese patients and 35 YO among controls ( P = NS). We conclude that a BMI below or equal to 30 is still justified as a prerequisite for placement on the waiting list for renal transplantation, for despite an overall improvement, the outcome of renal transplantation in obese patients remains worse than that in non-obese patients.

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“…In transplant recipients, obesity is also associated with heightened risk of infections, and post-transplant diabetes (49)(50)(51)(52)(53). One single-center study which included 2013 adult kidney transplants performed between 1984 and 1998, superficial or deep wound infections occurred in 4.8%, whereas 3.6% developed either a fascial dehiscence or hernia of the wound (54).…”

Section: Post-operative Complicationsmentioning

confidence: 99%

“…Delayed graft function (DGF), defined as the need for dialysis therapy in the first week after kidney transplantation, places a recipient at increased risk for chronic rejection and decreased graft survival. Only a minority of single-center studies have shown that obesity increases risk for decreased graft survival after kidney transplantation (46)(47)(48)(49)(50)(51)(52)(53) but this may be due to small sample sizes in these single-center studies. In a large study which included 51,927 kidney transplant recipients, severe obesity (BMI > 35 kg/m 2 ) was associated with a 51% increased risk of DGF compared to the transplant recipients with a BMI between 22-24 kg/m 2 (41).…”

Section: Post-operative Complicationsmentioning

confidence: 99%