Factors influencing the spontaneous reporting of adverse drug reactions—the experience of the Slovak Republic

Tisonova, J; Szalayova, A; Kriska, M; Gibala, P; Foltan, V

doi:10.1002/pds.889

Cited by 4 publications

(1 citation statement)

References 6 publications

(7 reference statements)

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“…The number of reports reached its climax in 1988 (Czechoslovakia) with 5,036 reports [1]. In the 1990s, the Czech State Institute for Drug Control (SÚ KL) recorded a significant drop in ADRs in CZ in spite of the fact that the number of granted drug licences significantly increased, including new molecules and vaccines [2].…”

Section: Introductionmentioning

confidence: 99%

Adverse drug reaction reporting in the Czech Republic 2005–2009

et al. 2011

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Our assessment of adverse drug reactions spontaneous reports received by the Czech Institute for Drug Control during 2005-2009 showed that the reporting rate is relatively low and remains constant over the 5 year period. More emphasis on academic/professional training is needed to educate all potential reporters on the mechanism of reporting of adverse drug reactions and to also emphasize the importance of the whole pharmacovigilance process.

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Section: Introductionmentioning

confidence: 99%

Adverse drug reaction reporting in the Czech Republic 2005–2009

et al. 2011

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Current awareness: Pharmacoepidemiology and drug safety

2004

Pharmacoepidemiology and Drug

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Adverse drug reactions of antidepressants and antipsychotics: Experience, knowledge and attitudes among Norwegian psychiatrists

Castberg

Reimers

Sandvik

et al. 2006

Nordic Journal of Psychiatry

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Efficient prevention of adverse drug reactions (ADRs) requires knowledge about their severity and pharmacological mechanisms and is dependent on reliable data on their frequencies and possible risk factors. The study was conducted to investigate the prescribers' experience and understanding of the ADRs of psychotropic drugs, and their attitude towards reporting these. In a questionnaire, physicians treating adult psychiatric patients were asked which ADRs that they regarded bothersome for some of the most widely used antidepressants and antipsychotics. Questions about the relationship between blockade of drug receptors and ADRs, and about the physicians' personal experience of and attitudes towards reporting of ADRs were also included. In total, 70 of 91 questionnaires (78%) were returned. The mean number of ADRs regarded bothersome ranged from 2.4 to 9.3 for the various drugs/drug classes. Qualified psychiatrists stated a significantly higher number of bothersome ADRs than did the residents. The percentage of physicians associating blockade of a receptor with a specific ADR varied from 76% (histamine receptor blockade and sedation) to 37% (alpha(1)-adrenergic blockade and tachycardia). Thirty-nine per cent of the physicians had never reported an ADR to the Norwegian Medicines Agency. The number of ADRs considered bothersome was relatively high. The pattern of these ADRs generally mirrored the typical ADR profiles of the drugs. The knowledge of the underlying mechanisms of ADRs was more or less incomplete. The reporting rate of ADRs to the national regulatory authorities was low.

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Factors influencing the spontaneous reporting of adverse drug reactions—the experience of the Slovak Republic

Cited by 4 publications

References 6 publications

Adverse drug reaction reporting in the Czech Republic 2005–2009

Adverse drug reaction reporting in the Czech Republic 2005–2009

Current awareness: Pharmacoepidemiology and drug safety

Adverse drug reactions of antidepressants and antipsychotics: Experience, knowledge and attitudes among Norwegian psychiatrists

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