Factors influencing the outcome of Escherichia coli mastitis in the dairy cow

Hill, Arthur W.

doi:10.1016/s0034-5288(18)32532-3

Cited by 182 publications

(64 citation statements)

References 9 publications

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“…Thus, all affected buffaloes were at early period of lactation (two weeks-two month). In cattle, clinical mastitis with grave systemic symptoms was found to occur at parturition and during early lactation, whereas during mid and late lactation signs are mild to moderate (Hill 1981). Moreover, many high producing cows are extremely sensitive for E. coli infections around parturition and during early lactation (Burvenich et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Acute coliform mastitis in buffaloes (Bubalus bubalis): Clinical findings and treatment outcomes

El-Khodery

Osman

2007

Trop Anim Health Prod

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This report was delineated to study the clinical, bacteriological and therapeutic aspects concerned with acute coliform mastitis in buffaloes. Bacteriological examination of 80 quarter milk samples obtained aseptically from 56 buffaloes with acute mastitis revealed that coliform bacteria was the most common pathogen (45 cases) followed by Staphylococcus aureus (seven cases) then Streptococcus uberis (three cases), and Streptococcus agalactiae (one case). Clinically, hotness, swelling and painful reaction with serous excretion containing clots was recorded in buffaloes with coliform mastitis. The efficacy of ceftiofur was evaluated in the treatment of buffaloes with acute coliform mastitis. Parenteral ceftiofur neither improved clinical signs nor returned milk to pre-infection production level, whereas intramammary ceftiofur and combination of intramammary with parenteral ceftiofur improved the clinical signs in 10/15 and 12/15 buffaloes, respectively. On quarter level, 3/17, 12/17 and 15/21 quarters recovered in groups received parenteral, intramammary and combination therapy, respectively. This study demonstrates that systemic ceftofur is not effective in the treatment of clinical coliform mastitis in buffaloes.

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Section: Discussionmentioning

confidence: 99%

Acute coliform mastitis in buffaloes (Bubalus bubalis): Clinical findings and treatment outcomes

El-Khodery

Osman

2007

Trop Anim Health Prod

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“…Their higher susceptibility was attributed to an inability to reduce bacterial growth during the first few hours after the bacterial inoculation because of a low somatic cell count before challenge and poor up-regulation of CD18 expression by stimulated neutrophils. Susceptibility to coliform mastitis has previously been associated with impaired recruitment of leucocytes to the infected gland in cows with a low somatic cell count (Hill 1981).…”

Section: Discussionmentioning

confidence: 99%

Case control study of risk factors for toxic mastitis in 26 dairy herds

et al. 1998

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A retrospective case control study of farm level risk factors for toxic mastitis was carried out in November and December 1996. Twenty-six farms from mid-Somerset were visited: 13 case farms (had had a cow with toxic mastitis in the previous year) and 13 geographically matched controls (no case of toxic mastitis). The farmers were interviewed and the buildings were examined. Information was collected on the type and quality of housing, usual milking routines, milk quality and mastitis prevalence in the previous year. All the data were collected on to pretested recording sheets and loaded into a database. Simple and complex analysis was done. The following variable were significantly (P < 0.05) associated with an increased risk of toxic mastitis in the simple analysis: housing cows in October rather than November; a low number of calving boxes per cow; a high proportion of cows with intermediate body condition and low herd bulk milk somatic cell counts (HBMSCC). In the final model low HBMSCC and a high proportion of cows with intermediate body condition remained significant. The authors conclude that, despite the small size sample, the results of this study are consistent, plausible and support the information from previous experimental and observational studies about the role of somatic cell counts in toxic mastitis.

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“…The mechanisms by which vaccination achieves these results are not convincingly identified. What is known is that neutrophils are critical to the control of infection and that a favorable outcome of E. coli mastitis depends on the prompt recruitment of active neutrophils into the mammary gland and milk 2, 3 . The role of antibodies is disputed 4 .…”

Section: Introductionmentioning

confidence: 99%

Local immunization impacts the response of dairy cows to Escherichia coli mastitis

Herry

Gitton

Tabouret

et al. 2017

Sci Rep

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Current vaccines to Escherichia coli mastitis have shown some albeit limited efficacy. Their mode of action has not been documented, and immune responses protecting the mammary gland against E. coli are not completely understood. To improve our knowledge of mammary gland immune protection, cows immunized either intramuscularly or intramammarily with the E. coli P4 were submitted to a homologous mastitis challenge. A third group of mock-immunized cows serve as challenge controls. Local immunization modified favorably the course of infection, by improving bacterial clearance while limiting inflammation. Systemic clinical signs and reduction in milk secretion were also contained. This occurred with a modification of the cytokine profile, such as an increase in IFN-γ and a reduction in TNF-α concentrations in milk. Concentrations of IL-17A and IL-22 increased in milk at the onset of the inflammatory response and remained high up to the elimination of bacteria, but concentrations did not differ between groups. Accelerated bacteriological cure was not linked to an increase in the initial efficiency of phagocytosis in milk. Results support the idea that antibodies did not play a major role in the improvement, and that cell-mediated immunity is the key to understanding E. coli vaccine-induced protection of the mammary gland.

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Factors influencing the outcome of Escherichia coli mastitis in the dairy cow

Cited by 182 publications

References 9 publications

Acute coliform mastitis in buffaloes (Bubalus bubalis): Clinical findings and treatment outcomes

Acute coliform mastitis in buffaloes (Bubalus bubalis): Clinical findings and treatment outcomes

Case control study of risk factors for toxic mastitis in 26 dairy herds

Local immunization impacts the response of dairy cows to Escherichia coli mastitis

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