1984
DOI: 10.1016/0090-1229(84)90273-3
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Factors influencing the human cytotoxic T cell response to autologous lymphoblastoid cell lines in vitro

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Cited by 18 publications
(7 citation statements)
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“…In both cases it was more prominent when keratinocytes were stimulated with IFN gamma, inducing HLA class IT antigen expression and increasing the intensity of HLA class I expression. Similar results have also been reported in which CD4+ lymphocyte mediated cytotoxicity was found to be specific for components of FCS present in the culture medium and taken up by target cells (21). In our experiments, human serum was used in culture medium for HSV antigen priming of T lymphocytes and the keratinocytes were cultured in FCS.…”
Section: Resultssupporting
confidence: 68%
“…In both cases it was more prominent when keratinocytes were stimulated with IFN gamma, inducing HLA class IT antigen expression and increasing the intensity of HLA class I expression. Similar results have also been reported in which CD4+ lymphocyte mediated cytotoxicity was found to be specific for components of FCS present in the culture medium and taken up by target cells (21). In our experiments, human serum was used in culture medium for HSV antigen priming of T lymphocytes and the keratinocytes were cultured in FCS.…”
Section: Resultssupporting
confidence: 68%
“…la.b.c)., although scif-prelerred lysis was dominant throughout. Both the FCS-and HS-grown autologous LCL were lysed equally well by the EBV-specilk CTL in keeping wiih previous findings thai virus-specific lysis is independent of scrum effects [19]. Second, the haploidentieal LCL target cells (donors 4,5,8) bearing the HLA-AI, -B8, -DR3 paternal haplotype were not lysed by the specific CTL (Fig.…”
Section: Cytotoxieity Asiayssupporting
confidence: 55%
“…It has been suggested that stimulation of CTL in the presence of FBS can result in FBS-specific killing (32,33). When PBMC from EBV-seropositive donors were reactivated with LCL in presence of either 10% FBS or 10% HABS, there was little difference in the increase in expression of CD25, which peaked at Ïł9 -11 days (Table IV).…”
Section: Cd25-sorted Ctl Are Ebv Specific Even When Fbs Is Present Imentioning
confidence: 97%