Factors influencing the functional outcome of restorative proctocolectomy in ulcerative colitis

Karlbom, Urban; Raab, Yngve; Ejerblad, S; Graf, Wilhelm; Thörn, Magnus; Påhlman, Lars

doi:10.1046/j.1365-2168.2000.01533.x

Cited by 36 publications

(28 citation statements)

References 25 publications

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“…Seven percent of these patients had developed chronic pouchitis. Although pouchitis has been reported to contribute to pouch dysfunction, 17 in the present study, it did not. Other authors have also reported that in patients followed up for more than ten years, function may remain good despite occasional episodes of pouchitis.…”

Section: Discussioncontrasting

confidence: 77%

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Is Ileoanal Pouch Function Stable with Time?

Bullard

Madoff

Gemlo

2002

Diseases of the Colon &Amp; Rectum

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Section: Discussioncontrasting

confidence: 77%

“…Median follow-up for the 37 patients with J-pouches was nine (mean, 9.4 Ϯ 1.6, range, [8][9][10][11][12][13][14][15][16][17] years. Major daytime incontinence was unchanged in 89 percent and worse in 11 percent.…”

Section: Resultsmentioning

confidence: 99%

Is Ileoanal Pouch Function Stable with Time?

Bullard

Madoff

Gemlo

2002

Diseases of the Colon &Amp; Rectum

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“…These data are in agreement with other reports 7,8 . Of the 3 deaths in the late follow-up, 2 patients died of cancer, 1 of which was colonic.…”

Section: Discussionsupporting

confidence: 83%

“…To what extent the presence of extraintestinal manifestations should influence the choice of surgical treatment is not clear. Further studies are required to address this issue 7 .…”

mentioning

confidence: 99%

Short- and long-term outcomes of ileal pouch-anal anastomosis for ulcerative colitis

et al. 2003

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Ileal pouch-anal anastomosis was an important advancement in the treatment of ulcerative colitis. The aim of this study was to determine whether early complications of ileal pouch-anal anastomosis in patients with ulcerative colitis are associated with poor late functional results. PATIENTS AND METHODS:Eighty patients were operated on from 1986 to 2000, 62 patients with ileostomy and 18 without. The early and late complications were recorded. Specific emphasis has been placed on the incidence of pouchitis with prolonged follow-up. RESULTS:The ileostomy was closed an average of 9.2 months after the first operation. Fourteen patients were excluded from the long-term evaluation; 6 patients were lost to regular follow-up, 4 died, and 4 patients still have the ileostomy. Of the 4 patients that died, 1 died from surgical complications. Early complications after operation (41) occurred in 34 patients (42.5%). Late complications (29) occurred in 25 patients as follows: 16 had pouchitis, 3 associated with stenosis and 1 with sexual dysfunction; 5 had stenosis; and there was 1 case each of incisional hernia, ileoanal fistula, hepatic cancer, and endometriosis. Pouchitis occurred in 6 patients (9.8%) 1 year after ileal pouch-anal anastomosis, 9 (14.8%) after 3 years, 13 (21.3%) after 5 years, and 16 (26.2%) after more than 6 years. The mean daily stool frequency was 12 before and 5.8 after operation. One pouch was removed because of fistulas that appeared 2 years later.CONCLUSIONS: Ileal pouch-anal anastomosis is associated with a considerable number of early complications. There was no correlation between pouchitis and severe disease, operation with or without ileostomy, or early postoperative complications. The incidence of pouchitis was directly proportional to duration of time of follow-up.

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“…Although this procedure is associated with low mortality, the postoperative morbidity caused by functional problems and complications is high. [3][4][5] In patients with UC, the most common long-term complication after IPAA is pouchitis. 4,[6][7][8][9] This acute, nonspecific, inflammatory condition of the ileal pouch can mimic inflammatory bowel disease.…”

mentioning

confidence: 99%

Delay of the First Onset of Pouchitis by Oral Intake of the Probiotic Strain Lactobacillus rhamnosus GG

Gosselink¹,

Schouten

Lieshout³

et al. 2004

Diseases of the Colon &Amp; Rectum

196

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Factors influencing the functional outcome of restorative proctocolectomy in ulcerative colitis

Abstract: While preoperative data may help in selecting patients suitable for restorative proctocolectomy, prevention of late complications seems most important in improving the functional outcome.

Cited by 36 publications

References 25 publications

Is Ileoanal Pouch Function Stable with Time?

Is Ileoanal Pouch Function Stable with Time?

Short- and long-term outcomes of ileal pouch-anal anastomosis for ulcerative colitis

Delay of the First Onset of Pouchitis by Oral Intake of the Probiotic Strain Lactobacillus rhamnosus GG

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