Factors influencing the capillary separation of leukocytes from whole blood in a plastic-based microfluidic chip

Isoda, Takaaki; Urushibara, I.; Umino, Kosuke; Ishida, Yasuaki; Sato, Hiroto

doi:10.1016/j.snb.2008.02.013

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Capillary flow does not require any power source and can proceed spontaneously. It has been widely used in microfluidics [30,31] based on its unique advantages of high economic performance, strong repeatability, and simple operation such as noninvasive sensing of sweat [32], detection of uric acid [33] or virus [34]. The dynamic process study of mixing and concentration gradient generation of two solutions under capillarity is lacking.…”

Section: Introductionmentioning

confidence: 99%

An embedded obstacle type micromixer‐concentration gradient generator based on capillary driven

Huang,

Wu,

Wang

et al. 2023

Electrophoresis

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An embedded obstacle‐type micromixer‐concentration gradient generator based on capillary self‐driven is proposed and studied. Herringbone structure (HS) for mixing and palisade‐shape small channels at the outlet are designed in the device (named HS). Simulation and experimentation are done to study the liquid mixing efficiency in the small channels and concentration gradient at the outlet, and the experimental results agree with the simulation results. For three cases of liquid dripping (sequential, reverse, and delayed drippings), mixing analysis shows that the mixing efficiency increases along both mixing channel and palisade length, and is high in the middle small channel of the palisade‐shape area and low on both sides. An obvious concentration gradient at the outlet can form compared with the device without the palisade‐shape area. Finally, water pH value detection is done as one of the applications of HS. This study can provide guidance for the application of HS in biochemical detection, cell research, drug screening, etc. based on the capillary‐driven effect.

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Section: Introductionmentioning

confidence: 99%

An embedded obstacle type micromixer‐concentration gradient generator based on capillary driven

Huang,

Wu,

Wang

et al. 2023

Electrophoresis

View full text Add to dashboard Cite

show abstract

“…Those have been generally applied to the measurement of small analytes such as therapeutic drugs and hormones [2,3]. However, heterogeneous immunoassay requires an extra step to remove unbound antibody or antigen from the site, usually utilizing a solid phase support such as a magnetic particle [4,5], plastic bead [6,7], and nitrocellulose membrane [8][9][10][11][12][13]. Covalent crosslinking of antibodies on chemically-activated solid surfaces is the most common and stable method for antibody immobilization.…”

Section: Introductionmentioning

confidence: 99%

Preliminary studies of application of eggshell membrane as immobilization platform in sandwich immunoassay

Tang

Kang

et al. 2009

Sensors and Actuators B: Chemical

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Factors influencing the capillary separation of leukocytes from whole blood in a plastic-based microfluidic chip

Cited by 2 publications

References 21 publications

An embedded obstacle type micromixer‐concentration gradient generator based on capillary driven

An embedded obstacle type micromixer‐concentration gradient generator based on capillary driven

Preliminary studies of application of eggshell membrane as immobilization platform in sandwich immunoassay

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