The growth of the senior population and the rise in chronic illnesses such as non-communicable diseases (NCDs) are placing significant strain on modern healthcare systems. The demand for resources from hospital beds to doctors and nurses is high in Upper-Middle-Income countries like Malaysia. The use of IoT technologies can give aged people at home uninterrupted access to healthcare resources and better control over their health. This study aims to analyze the key antecedents of the actual behavior of IoT technologies among aged NCD patients in Malaysia under a framework covering the unified theory of acceptance and use of technology model, technology acceptance model, and theory of planned behavior. This cross-sectional study used a purposive sampling technique and data were analyzed using SmartPLS. The outcome is expected to help the government and healthcare policymakers develop awareness among the senior community on the use of IoT-based smart wearables for routine self-monitoring of NCDs.