“…Thus, a larger sample size would be desirable for a prospective follow-up study, preferably one comparing the results of other software programs using different mesh deformation models to the model used in the present study. Literature has shown a variety of factors affecting the accuracy of predictions of soft tissue outcomes: gender, race, soft tissue thickness, mean ratios of soft tissue to hard tissue movements, biological factors, relapse, method-related factors (reproducibility in landmark identification and computer digitization), magnitude of skeletal repositioning, number of oral surgeons involved, pre-surgical orthodontics, condylar displacement, and mandibular center of rotation [ 53 ].…”