Factors influencing survival after resection for ductal adenocarcinoma of the head of the pancreas

Benassai, Giacomo; M, Mastrorilli; Quarto, Gennaro; Cappiello, Antonino Pierluigi; Giani, Umberto; Forestieri, Pietro; Mazzeo, F

doi:10.1002/(sici)1096-9098(200004)73:4<212::aid-jso5>3.0.co;2-d

Cited by 177 publications

(131 citation statements)

References 46 publications

(47 reference statements)

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“…RT is not implemented in metastatic patients except palliative treatment might have caused patient selection bias. The fact that the tumor grade is an important prognostic factor is shown in many studies [17][18][19]. However, no relationship is determined between the tumor grade and survival in our study.…”

Section: Discussioncontrasting

confidence: 64%

Clinicopathologic Prognostic Factors in Locally Advanced Pancreatic Cancer Patients Treated with Radiation Therapy

Kaya¹

2015

Ann Clin Anal Med

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Anahtar KelimelerPankreas Kanseri; Radyoterapi; Lenf Nodu Durumu; Tümör Çapı Abstract Aim: The prognosis of pancreatic cancer is one of the worst malignancies. In randomized clinical trials done in recent times, the answer is researched for adjuvant chemotherapy, chemoradiotherapy. Our study investigated the clinicopathologic prognostic factors for pancreatic cancer. Material and Method: Patients diagnosed with histopathologically confirmed pancreatic cancer, followed by Akdeniz University School of Medicine, Department of Radiation Oncology between the years 2000-2008 were included in the study. Results: A total number of 32 patients were taken to the study. The tumor diameter values in predicting survival were analyzed using ROC (Receiver Operating Characteristics) curve analysis. Patients were grouped according to their tumor diameters: the tumor diameter lower than 4 cm (Group A), the tumor diameter higher than 4 cm (Group B). The mean survival of patients is determined as 17.3 months. The fact that there is whether or not lymph node involvement is found to be related with survival (p=0.009). A significant relationship between Group A and B in terms of survival is determined (p=0.029). Conclusions: While treatment is considered in patients who are planned to receive radiation therapy because of pancreatic cancer, the tumor diameter and the lymph node status should be taken into account as prognostic factors.

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Section: Discussioncontrasting

confidence: 64%

Clinicopathologic Prognostic Factors in Locally Advanced Pancreatic Cancer Patients Treated with Radiation Therapy

Kaya¹

2015

Ann Clin Anal Med

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“…The median operating time for patient undergoing pancreatic resection for pancreatic adenocarcinoma was 6.3 hours as per 8 studies providing these data comprising of 4906 patients. 4,[17][18][19][34][35][36]44 Peri-operative mortality or mortality within 30 days of the date of operation was found to be 2.12% (N=117) in 13 studies providing this data with total of 5512 patients. [34][35][36]41 including 504 patients compared data of 3-year survival rates.…”

Section: Systematic Review Operation Intra-operative and Post-operatmentioning

confidence: 97%

“…8,[30][31][32] Finally, 18 articles were included after reading the full papers (Table 1). 4,[15][16][17][18][19][33][34][35][36][37][38][39][40][41][42][43][44] …”

Section: Search Strategy and Study Identificationmentioning

confidence: 99%

“…Three year survival rate of 25.6% and 14.36% was seen with tumor size <3 cm and >3 cm respectively and the result being statistically significant (P<0.01) (Table 3). Finally, a total of 5 studies 18,19,35,36,41 with 958 patients provided data on 5-year survival rates. 5-year survival rate of 23.72% and 9.70% was seen with tumor size <3 cm and >3 cm respectively and the result being statistically significant (P<0.001) ( Table 3).…”

Section: Systematic Review Operation Intra-operative and Post-operatmentioning

confidence: 99%

“…Tumor diameter with 3cm and 4 cm cut-offs are not specified in the staging and thus causing conflicts about selection of the tumor size cut-off in defining the tumor stage. Many studies have favored the AJCC tumor staging cut-off of 2 cm, [14][15][16] whereas there are studies [17][18][19] which reports the indication for reconsideration of the tumor stage cut-off, to provide more precise reference for staging and predicting survival outcome. Moreover, the impact of tumor size on survival outcome also remains controversial.…”

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confidence: 99%

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Impact of tumor size on survival outcome of pancreatic carcinoma following pancreatic resection: A systematic review and meta-analysis

Shrestha

Baskota

et al. 2018

Asian J Med Sci

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A B S T R A C T REVIEW ARTICLE ASIAN JOURNAL OF MEDICAL SCIENCESThe aim of the study was to evaluate the influence of tumor size on long-term survival outcome of pancreatic tumors following pancreatic resection and the possibility of implementing another tumor size cut-off point in AJCC pancreatic tumor staging. Literature searches was conducted on electronic database to identify relevant studies on tumor size related survival outcome following pancreatic resection for pancreatic adenocarcinoma. Meta-analysis was done using the effect estimates and the use of 95% confidence intervals (CIs) was done to calculate the pooled risk estimates; heterogeneity among studies was examined using I 2 statistic. Total of 18 trials (13 retrospective and 5 prospective studies) including 6230 elderly patients was included in this study. The pooled HR of the tumor size with 2 cm cut-off was 1.43 with 95% CI of [1.27-1.62], I 2 = 17%, p<0.00001 and was statistically significant. Median survival for tumor size <2, >2, <3, >3, <4 and >4 were 41.02 months, 16.20 months, 19.41 months, 10.79 months, 24.2 months and 15.14 months respectively and the 1-, 3-, and 5-year survival rate decreased with increasing tumor diameter. Importantly, a total of four studies results indicated that 3-year survival rate and a total of five studies results indicated that 5-year survival rate had statistical significance with 3 cm cut-off. Tumor diameter of 2 cm seems to be a reasonable but relatively less comprehensive cut-off point. 3 cm cut-off maybe become a new potential tumor size cut-off point in addition to the current sole 2 cm cut-off point defining tumor stage.

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Significance of the Depth of Portal Vein Wall Invasion After Curative Resection for Pancreatic Adenocarcinoma

Fukuda

Oussoultzoglou²,

Bachellier³

et al. 2007

Arch Surg

109

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Factors influencing survival after resection for ductal adenocarcinoma of the head of the pancreas

Cited by 177 publications

References 46 publications

Clinicopathologic Prognostic Factors in Locally Advanced Pancreatic Cancer Patients Treated with Radiation Therapy

Clinicopathologic Prognostic Factors in Locally Advanced Pancreatic Cancer Patients Treated with Radiation Therapy

Impact of tumor size on survival outcome of pancreatic carcinoma following pancreatic resection: A systematic review and meta-analysis

Significance of the Depth of Portal Vein Wall Invasion After Curative Resection for Pancreatic Adenocarcinoma

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