Factors Influencing Stability of Prednisolone in Aqueous Solution

Oesterling, T.O.; Guttman, David E.

doi:10.1002/jps.2600531012

Cited by 35 publications

(12 citation statements)

References 6 publications

(3 reference statements)

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“…The results obtained with this chelating agent confirm that metallic-ion impurities are a major cause of degradation. The source of impurities was at first thought to be the buffer salts, since they can contain significant amounts of metallic-ion contaminants (6). However, in the present work, metallic impurities leached from the containers were more important.…”

contrasting

confidence: 45%

Factors Influencing Decomposition Rate of Amitriptyline Hydrochloride in Aqueous Solution

Enever

Shotton

1977

Journal of Pharmaceutical Sciences

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contrasting

confidence: 45%

Factors Influencing Decomposition Rate of Amitriptyline Hydrochloride in Aqueous Solution

Enever

Shotton

1977

Journal of Pharmaceutical Sciences

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“…In fact, the sum of PD and the degradation product was 100.9 8 6.2% of the target value. PD is susceptible to degradation which involves the 20-keto group resulting in the formation of the respective 17-ketosteroid [42] ; instability is enhanced by higher temperatures [43] . Verification of this product, however, was excluded as a reference substance was not available.…”

Section: Characterization Of the Formulationsmentioning

confidence: 99%

Drug Release and Skin Penetration from Solid Lipid Nanoparticles and a Base Cream: A Systematic Approach from a Comparison of Three Glucocorticoids

Schlupp

Blaschke²,

Kramer³

et al. 2011

Skin Pharmacol Physiol

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Solid lipid nanoparticles (SLNs) can enhance drug penetration into the skin, yet the mechanism of the improved transport is not known in full. To unravel the influence of the drug-particle interaction on penetration enhancement, 3 glucocorticoids (GCs), prednisolone (PD), the diester prednicarbate (PC) and the monoester betamethasone 17-valerate (BMV), varying in structure and lipophilicity, were loaded onto SLNs. Theoretical permeability coefficients (cm/s) of the agents rank BMV (–6.38) ≧ PC (–6.57) > PD (–7.30). GC-particle interaction, drug release and skin penetration were investigated including a conventional oil-in-water cream for reference. Both with SLN and cream, PD release was clearly superior to PC release which exceeded BMV release. With the cream, the rank order did not change when studying skin penetration, and skin penetration is thus predominantly influenced by drug release. Yet, the penetration profile for the GCs loaded onto SLNs completely changed, and differences between the steroids were almost lost. Thus, SLNs influence skin penetration by an intrinsic mechanism linked to a specific interaction of the drug-carrier complex and the skin surface, which becomes possible by the lipid nature and nanosize of the carrier and appears not to be derived by testing drug release. Interestingly, PC and PD uptake from SLN even resulted in epidermal targeting. Thus, SLNs are not only able to improve skin penetration of topically applied drugs, but may also be of particular interest when specifically aiming to influence epidermal dysfunction.

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“…Recent work has shown that the decomposition of 111 was metal catalyzed and that EDTA significantly decreased the rate of decomposition (12). Indeed, buffer effects were rationalized on the basis of trace metal contaminants both for hydrocortisone (12) and prednisolone (16).…”

mentioning

confidence: 99%

Kinetics of Decomposition and Formulation of Hydrocortisone Butyrate in Semiaqueous and Gel Systems

Yip

Pox

Irwin

1983

Journal of Pharmaceutical Sciences

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Factors Influencing Stability of Prednisolone in Aqueous Solution

Cited by 35 publications

References 6 publications

Factors Influencing Decomposition Rate of Amitriptyline Hydrochloride in Aqueous Solution

Factors Influencing Decomposition Rate of Amitriptyline Hydrochloride in Aqueous Solution

Drug Release and Skin Penetration from Solid Lipid Nanoparticles and a Base Cream: A Systematic Approach from a Comparison of Three Glucocorticoids

Kinetics of Decomposition and Formulation of Hydrocortisone Butyrate in Semiaqueous and Gel Systems

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