Factors influencing recovery in patients with hemoblastoses and candidemia

Klyasova, Galina; В, Блохина Е; Gracheva, Alexandra; Кравченко, С К; Паровичникова, Е Н; Охмат, В А; Коробова, А Г; Galstyan, G. M.; Kulikov, Sergey

doi:10.17116/terarkh201587777-87

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…Использование флуконазола допустимо при реализации ступенчатой терапии для больных с кандидемией, у которых при стартовом применении эхинокандина достигнуто клиническое улучшение и выделены изоляты Candida spp., чувствительные к флуконазолу. В исследованиях, представленных нами ранее, также отмечено статистически значимое увеличение выживаемости при кандидемии, если в первой линии терапии использовали эхинокандин [28]. Результаты этой работы также подтвердили более высокую выживаемость при кандидемии, вызванной как C. albicans, так и C. non-albicans, если лечение проводили эхинокандином в сравнении с другим противогрибковым препаратом.…”

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Treatment of candidemia caused by Candida albicans and Candida non - albicans in patients with hematological malignancies

Klyasova¹,

Мальчикова²,

Тандилова³

et al. 2019

Terapevticheskii arkhiv

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Aim. To study the risk factors, symptoms and outcomes of candidemia caused by C. albicans and C. non - albicans in patients with hematological malignancies. Materials and methods. The study included patients with hematological malignancies and candidemia. The diagnosis of candidemia was established according to the single isolation of Candida spp. from blood culture and the presence of symptoms of infection. Results and discussion. Over 12 years (2006-2017), candidemia was diagnosed in 75 patients aged 17 to 77 years (median 48 years). The causative agents of candidemia were C. albicans in 34.7% of patients, C. non - albicans - in 65.3%. Candidemia caused by C. albicans prevailed in patients of the older age group (median 56.5 years, p=0.04) and in patients with lymphoma (61.5%, p=0.01) with colonization of the gut by the same species of Candida (88.5%, p=0.002). Isolation of C. non - albicans from blood culture was more common in patients with acute leukemia (51%, p=0.01) and in recipients of allogeneic hematopoietic stem cells (22.5%, p=0.01). The ability to form biofilms was observed more frequently among C. non - albicans (59.2%) than C. albicans (19.2%, p=0.001). The clinical symptoms of candidemia were non - specific (fever was in 97%). Septic shock developed in 25 (33%) patients with comparable frequency in both groups. Concomitant infections was also comparable (73% vs. 73.5%). Overall 30-day survival in patients with candidemia caused by C. albicans and C. non - albicans was 61.2% and 61.5%. Treatment with echinocandin was associated with increase of survival compared to other antifungal agents among patients with C. albicans candidaemia (88.9% versus 40%, p=0.02) and among C. non - albicans (77.3% versus 47.8%). Conclusion. C. non - albicans constituted a high proportion among causative agents of candidemia. High mortality rate was observed in both groups. Initial therapy with echinocandin was associated with increase of survival.

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Section: время дниunclassified

Treatment of candidemia caused by Candida albicans and Candida non - albicans in patients with hematological malignancies

Klyasova¹,

Мальчикова²,

Тандилова³

et al. 2019

Terapevticheskii arkhiv

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Biofilm formation by Candida spp. isolated from blood culture in patients with or without hematological malignancies

Мальчикова

Klyasova

2018

CMAC

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Objective. To evaluate the biofilm formation by isolates of Candida spp. obtained from blood culture in patients with or without hematological malignancies. Materials and Methods. Biofilm formation by Candida spp. was determined by the method of Pierce C. and Tumbarello M. Isolates with optical density (OD) >0.1 were considered as biofilm-forming. Results. A total of 109 isolates of Candida spp. (C. albicans [n=22], C. parapsilosis [n=22], C. tropicalis [n=22], C. krusei [n=21], C. glabrata [n=22]) obtained from patients with or without hematological malignancies (55 and 54 isolates, respectively) were studied. Biofilm formation was determined in 54% of Candida spp. isolates (n=59). Biofilm production was observed more often in non-albicans species compared to C. albicans (60% versus 32%, p=0.02). The incidence of biofilm formation was significantly higher in isolates of C. tropicalis (82%) and C. krusei (81%) compared to isolates of C. parapsilosis (50%), C. albicans (32%), and C. glabrata (27%) (p<0.05). The leading biofilm-forming species were C. tropicalis and C. krusei in the both patient cohorts. Biofilm production was more frequent in C. parapsilosis isolated from patients with hematological malignancies compared to patients without hematological malignancies (73% versus 27%, p=0.03). The lowest incidence of biofilm formation was found in C. albicans (18%) isolated from patients with hematological malignancies and C. glabrata (18%) isolated from patients without hematological malignancies. Conclusions. Biofilm formation varied among the Candida spp., with the highest incidence in C. tropicalis (82%) and C. krusei (81%). There were differences in the biofilm formation incidence among Candida spp. isolated from patients with or without hematological malignancies.

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Factors influencing recovery in patients with hemoblastoses and candidemia

Cited by 2 publications

References 25 publications

Treatment of candidemia caused by Candida albicans and Candida non - albicans in patients with hematological malignancies

Treatment of candidemia caused by Candida albicans and Candida non - albicans in patients with hematological malignancies

Biofilm formation by Candida spp. isolated from blood culture in patients with or without hematological malignancies

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