Factors influencing quality of life in patients with active tuberculosis

Marra, Carlo; Marra, Fawziah; Cox, Victoria; Palepu, Anita; FitzGerald, J. Mark

doi:10.1186/1477-7525-2-58

Cited by 77 publications

(75 citation statements)

References 14 publications

(12 reference statements)

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“…The long treatment period was poorly understood by patients [23,26,28,38–40,46,52]; and adherence appeared to be facilitated where patients understood the importance of completing treatment [24,26,32,36,39,44,55,58,59]. One study on adherence to prophylaxis reported that nonadherent patients had little information on TB as a disease, but were very aware of the potential adverse effects caused by treatment [44].…”

Section: Resultsmentioning

confidence: 99%

“…Patients' beliefs about the efficacy of treatment, both positive [39,41,52,59] and negative [22,23,26,28,32,34,36,39,44,52,54–56], may impact on adherence. Patients may question the efficacy of the pills or think that only injections are “medicine” [22], or even question the validity of diagnostic tests that are not considered sophisticated enough for such a dangerous disease [52].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research

et al. 2007

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BackgroundTuberculosis (TB) is a major contributor to the global burden of disease and has received considerable attention in recent years, particularly in low- and middle-income countries where it is closely associated with HIV/AIDS. Poor adherence to treatment is common despite various interventions aimed at improving treatment completion. Lack of a comprehensive and holistic understanding of barriers to and facilitators of, treatment adherence is currently a major obstacle to finding effective solutions. The aim of this systematic review of qualitative studies was to understand the factors considered important by patients, caregivers and health care providers in contributing to TB medication adherence.Methods and FindingsWe searched 19 electronic databases (1966–February 2005) for qualitative studies on patients', caregivers', or health care providers' perceptions of adherence to preventive or curative TB treatment with the free text terms “Tuberculosis AND (adherence OR compliance OR concordance)”. We supplemented our search with citation searches and by consulting experts. For included studies, study quality was assessed using a predetermined checklist and data were extracted independently onto a standard form. We then followed Noblit and Hare's method of meta-ethnography to synthesize the findings, using both reciprocal translation and line-of-argument synthesis. We screened 7,814 citations and selected 44 articles that met the prespecified inclusion criteria. The synthesis offers an overview of qualitative evidence derived from these multiple international studies. We identified eight major themes across the studies: organisation of treatment and care; interpretations of illness and wellness; the financial burden of treatment; knowledge, attitudes, and beliefs about treatment; law and immigration; personal characteristics and adherence behaviour; side effects; and family, community, and household support. Our interpretation of the themes across all studies produced a line-of-argument synthesis describing how four major factors interact to affect adherence to TB treatment: structural factors, including poverty and gender discrimination; the social context; health service factors; and personal factors. The findings of this study are limited by the quality and foci of the included studies.ConclusionsAdherence to the long course of TB treatment is a complex, dynamic phenomenon with a wide range of factors impacting on treatment-taking behaviour. Patients' adherence to their medication regimens was influenced by the interaction of a number of these factors. The findings of our review could help inform the development of patient-centred interventions and of interventions to address structural barriers to treatment adherence.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research

et al. 2007

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“…Although previous studies suggested that discrimination experience was negatively related to perceived QOL [7,11,17,18], it is still unclear whether effects of discrimination experience on QOL would be mediated by some individual's cognitive variables, such as the premigratory expectation or aspiration. The theory of goal-striving stress (TGSS) proposes that discrepancy between a migrant's premigratory aspiration and postmigration achievement (e.g., goal-striving stress or unfulfilled aspiration) is the source of mental distress [33].…”

Section: Introductionmentioning

confidence: 96%

Discrimination experience and quality of life among rural-to-urban migrants in China: the mediation effect of expectation–reality discrepancy

Zhang

Fang

et al. 2009

Qual Life Res

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“…21 Also, most of the respondents in this study group were married (61.6%) and this can be compared to a study done in North India which showed that about two-thirds of the participants were married among many other earlier studies which also supported the same finding. 21,25,26 About three-fifth of the respondents in this study were Christians; this is adjudged to be closely linked with the predominance of both Yoruba and Ibo tribes in the study population and more reflective of Christianity as the more predominant religion among both ethnic groups. More than half of the respondents earn income lower than 40,000 naira ($200) monthly and about two-third earned below the national monthly minimum wage of 20,000 naira ($100); which would have constituted a great problem to the control of this communicable disease.…”

Section: Socio-demographic Profile Of Participantsmentioning

confidence: 99%

“…Similar findings have been observed on the influence of age, sex, marital status and income on the QoL of people with TB. 26 More over a cross-sectional study in Estonia found similar socio-demographic factors (including age under 30 years, female gender and being employed) to significantly increased QoL.…”

Section: Profile Of Qol and The Determinants Among Participantsmentioning

confidence: 99%

Evaluation of the roles of HIV co-infection and socio-demographic factors as determinants of Quality of Life among Nigerians with Tuberculosis

Olagunju

Odukoya

Olagunju

et al. 2018

Bangladesh J Med Sci

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Background: Tuberculosis [TB] remains a major global public health problem, and particularly in resource-restricted settings with disproportionately high burden. This study is aimed at assessing quality of life [QoL] and the roles of HIV co-infection along with socio-demographic factors on QoL among subjects with TB. Methodology: This is a multi-center cross-sectional study among 440 participants recruited by multi-stage sampling technique across 40 Directly Observed Treatment Short-course [DOTS] centres. Interviews were done using designed questionnaire to collect information on socio-demographic and clinical details of respondents. Subsequently, the World Health Organization Quality of Life-BREF [WHOQOL-BREF] questionnaire was used to evaluate QoL. Results: Most (61.1%) of the participants was aged between 21 and 40 years, 61.6% were married and 74.5% had a paid job. Majority of the subjects reported fair QoL across all domains. Employment status and monthly income were significantly associated with participants overall QoL and their satisfaction with health (p<0.05). Also, age, gender, marital status, ethnicity and educational status were significantly associated with the social domain of QoL. The HIV co-infection was found to be significantly associated with the physical aspect of their QoL (p<0.05). Conclusion: Optimal treatment of HIV co-infection and incorporation of psychosocial medicine into TB management are indicated for improved QoL. Similarly, routine assessment of QoL is desirable.

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Factors influencing quality of life in patients with active tuberculosis

Cited by 77 publications

References 14 publications

Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research

Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research

Discrimination experience and quality of life among rural-to-urban migrants in China: the mediation effect of expectation–reality discrepancy

Evaluation of the roles of HIV co-infection and socio-demographic factors as determinants of Quality of Life among Nigerians with Tuberculosis

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