Factors Influencing Protein Secretion in Human Saliva

Dawes, C.M

doi:10.1159/000400254

Cited by 26 publications

(20 citation statements)

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“…Together with our results, this is a reasonable explanation for the failure to detect sIgA in studies with a similar age group but a smaller study population [7][8][9][10]. The concentration of sIgA in saliva depends on a number of factors [18][19][20] including the concentration of proteins and the amount of water produced by different glands or penetrating passively into the oral cavity. Appearance of high values of albumin is explained with a leakage from serum mainly caused by mucosal inflammation [4].…”

Section: Discussionsupporting

confidence: 77%

“…We aspirated saliva with a syringe connected to a sterile polyethylene tube. Though this technique may have caused some degree of stimulation and variability [16,17], we noticed it as being non-invasive and causing only minimal stress for the infant; the latter has been discussed as an interfering factor on the secretion of sIgA [18][19][20]. Furthermore, centrifugation of saliva may lead to an underestimation of sIgA values due to binding of salivary proteins to pellet compounds [21].…”

Section: Discussionmentioning

confidence: 99%

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Determination of Secretory IgA and Albumin in Saliva of Newborn Infants

Seidel

Schulze²,

Kieß³

et al. 2000

Neonatology

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As a first line of defence against microbial invasion, secretory IgA (sIgA) is the dominant immunoglobulin on all mucosal surfaces. In this study sIgA was determined by radial immunodiffusion in saliva samples of 63 newborn infants divided into the following age groups: (1) 1 day and younger, (2) 2–10 days. Concentrations of sIgA and albumin as well as their relation to age, postprandial time, gestational age and birth weight were analysed. sIgA could be detected in 75.0% (group 1) and 77.1% (group 2) of the saliva samples with a mean concentration of 190.2 mg/l (group 1) and 216.4 mg/l (group 2). Differences failed to reach significance. Concentration of sIgA was found to be independent of age but positively related to the concentration of albumin in the same saliva sample. In conclusion, this study provides evidence that high levels of sIgA are found in saliva of newborn infants, indicating the existence of a competent oral mucosal immune system as early as within the first 10 days of life.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Determination of Secretory IgA and Albumin in Saliva of Newborn Infants

Seidel

Schulze²,

Kieß³

et al. 2000

Neonatology

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“…The composition of saliva is dependent on a number of factors, including flow rate and circadian rhythms (24), intake of drugs (25,26) and certain diseases. Before commencing saliva analyses, there are aspects to be considered and these include the total number of parameters to be determined and volume of saliva required, the types of salivary samples (stimulated, unstimulated, whole saliva or that from individual glands), storage conditions (no storage, 4°C,-20°C or below) and pretreatment of saliva (centrifugation, sonication, dividing into aliquots).…”

Section: Available Data -How Conclusive Is It In Comparing Studiesmentioning

confidence: 99%

Saliva In Research And Clinical Diagnosis

Rahim

1998

ADUM

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Saliva collection is non-invasive and less stressful when compared with blood collection. Extensive studies on saliva has been carried out and the use of saliva as a biological sample in clinical diagnosis and for monitoring hormones, drugs and pollutants and viruses has been recommended. The complexities associated with saliva such as proper collection device and strict standardisation of a number of factors which include time of collection, types of saliva and storage made it less favourable to blood.

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“…All samples were collected between the hours of 2:00 pm and 3:00 pm as earlier studies had indicated some diurnal variation in saliva production and presumably composition [4,35,36]. Both the collection time and the volume produced were recorded for all individuals so that flow rates could be calculated.…”

Section: Sample Procurementmentioning

confidence: 99%

“…In addition to moistening the mucosa, aiding the digestive process, providing ions for remineralization, and chemically buffering the oral cavity, saliva provides lubrication of oral tissues I- [1][2][3][4][5][6][7][8][9][10][11][12]. The lubricating capacity of saliva has intuitively been correlated with the viscosity of the secretion by previous investigators [7,[12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Rheology of stimulated whole saliva in a typical pre-orthodontic sample population

Kusy

Schäfer

1995

J Mater Sci: Mater Med

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The dynamic viscosity (t~) of stimulated whole saliVa in a typical pre-orthodontic sample population was characterized as a function of temperature (T). Samples were collected from 30 adolescents or young adults, after screening for factors that are known to have an effect on salivary viscosity. Using a cone and plate viscometer, 1.5 ml of stimulated whole saliva was evaluated at a constant shear rate of 450s -1 from T=20°C to T= 40°C. Data from the I~-T plots showed a negative dependence of the form, p = a-bT, over a range of I~ from 1.08 to 2.45 centipoise (cps) at 34 °C. Most of the samples fell into a narrow envelope, where the mean I~ of the saliva samples ranged from 2.42+0.61 cps at 20°C to 1.57_+0.32 cps at 37°C. With regard to sample stability, viscosity-time plots indicated that a small but predictable decrease in t~ occurred during the 3 h period. The i~-Tplots generated from fresh and frozen saliva samples demonstrated an appreciable change in p as a result of refrigeration. With regard to sample reproducibility, viscometric data obtained from a typical pre-orthodontic patient over a 1-week period fluctuated within a fairly broad envelope of values.

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Factors Influencing Protein Secretion in Human Saliva

Cited by 26 publications

References 0 publications

Determination of Secretory IgA and Albumin in Saliva of Newborn Infants

Determination of Secretory IgA and Albumin in Saliva of Newborn Infants

Saliva In Research And Clinical Diagnosis

Rheology of stimulated whole saliva in a typical pre-orthodontic sample population

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