Factors influencing pre‐operative urinary calcium excretion in primary hyperparathyroidism

Kaderli, Reto; Riss, Philipp; Geroldinger, Angelika; Selberherr, Andreas; Scheuba, Christian; Niederle, Bruno

doi:10.1111/cen.13348

Cited by 2 publications

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“…Kaderli et al showed that the parameters affecting CCCR in subjects with PHPT were 1,25(OH)2D and osteocalcin. 12 Analyzing CCCR, 20.2% of the patients in our study showed evidence of FHH, 30.7% showed evidence of PHPT, and 49.1% were in the gray area. Unfortunately, CCCR was of little assistance in confirming diagnoses.…”

Section: Discussionmentioning

confidence: 62%

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Efficacy of calcium excretion and calcium/creatinine clearance ratio in the differential diagnosis of familial hypocalciuric hypercalcemia and primary hyperparathyroidism

et al. 2018

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Background Twenty‐four‐hour renal calcium‐excretion (CE) and calcium/creatinine‐clearance‐ratio (CCCR), respectively, are widely used to rule out familial hypocalciuric hypercalcemia (FHH) in patients with suspected primary hyperparathyroidism before surgery. The aim was to evaluate the practicability of CE compared to CCCR. Patients and Methods We analyzed biochemical parameters, surgical treatment, gene mutation results, and long‐term follow‐up data of 198 patients (including 14 patients with FHH) and the discriminative power of CE and CCCR. Results Twenty four patients (12.1%) had a low CE and 35 patients (20.2%) had a CCCR indicating FHH. However, eight patients with FHH (57.1%) had a normal or increased CE. Correspondingly, only eight cases of FHH (57.1%) were correctly predicted by CCCR. Sensitivity/specificity were 42.9%/89.9% for CE and 64.3%/79.9% for CCCR, showing no statistical differences (P = 0.482) between both methods. Conclusion Neither CE nor CCCR was able to distinguish between PHPT and FHH but may help to narrow down potential FHH patients.

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Section: Discussionmentioning

confidence: 62%

“…On the other hand, the evaluation of CCCR yielded 35 FHH (20.2%) and 53 PHPT (30.7%) suspected cases in our study group. Kaderli et al showed that the parameters affecting CCCR in subjects with PHPT were 1,25(OH)2D and osteocalcin …”

Section: Discussionmentioning

confidence: 99%

Efficacy of calcium excretion and calcium/creatinine clearance ratio in the differential diagnosis of familial hypocalciuric hypercalcemia and primary hyperparathyroidism

et al. 2018

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Calcium-Creatinine Clearance Ratio is not Helpful in Differentiating Primary Hyperparathyroidism from Familial Hypercalcemic Hypocalciuria: A Study of 1,000 Patients

et al. 2018

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Factors influencing pre‐operative urinary calcium excretion in primary hyperparathyroidism

Abstract: In multivariable analysis, 1,25-(OH)2 D3 and osteocalcin were the only factors correlating with CCCR. Vitamin D3 replacement may therefore impair the diagnostic value of CCCR and increase the importance of close monitoring of urinary Ca excretion during treatment.

Cited by 2 publications

References 25 publications

Efficacy of calcium excretion and calcium/creatinine clearance ratio in the differential diagnosis of familial hypocalciuric hypercalcemia and primary hyperparathyroidism

Efficacy of calcium excretion and calcium/creatinine clearance ratio in the differential diagnosis of familial hypocalciuric hypercalcemia and primary hyperparathyroidism

Calcium-Creatinine Clearance Ratio is not Helpful in Differentiating Primary Hyperparathyroidism from Familial Hypercalcemic Hypocalciuria: A Study of 1,000 Patients

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