Factors influencing enlargement rate of small abdominal aortic aneurysms

Sterpetti, Antonio V.; Schultz, Richard D.; Feldhaus, Richard J.; Cheng, Shih E.; Peetz, Dwaine J.

doi:10.1016/0022-4804(87)90073-4

Cited by 127 publications

(65 citation statements)

References 5 publications

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“…The pathogenesis of aortic aneurysm appears to be characterized by widespread destruction of elastic lamellae in the media (1-3), medial neovascularization (4), a decrease in vascular smooth muscle cells (5), and a chronic inflammatory response in the of years with a substantial number of aneurysmal aortae eventually rupturing (13)(14)(15). The pathophysiology of the aneurysmal aorta includes aortic atherosclerosis, chronic inflammation within the outer aortic wall, and an imbalance between the production and degradation of structural extracellular matrix proteins (16).…”

Section: Introductionmentioning

confidence: 99%

Possible Roles of Angiotensin II-Forming Enzymes, Angiotensin Converting Enzyme and Chymase-like Enzyme, in the Human Aneurysmal Aorta.

et al. 2002

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Section: Introductionmentioning

confidence: 99%

Possible Roles of Angiotensin II-Forming Enzymes, Angiotensin Converting Enzyme and Chymase-like Enzyme, in the Human Aneurysmal Aorta.

et al. 2002

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“…Although the immediate risk associated with small symptomatic aneurysmal aorta is very low, the natural history of these lesions involves gradual expansion over a period of years with a substantial number of aneurysmal aorta eventually rupturing (Delin et al, 1985;Sterpetti et al, 1987;Nevitt et al, 1989). The pathophysiology of aneurysmal aorta includes aortic atheroscrelosis, chronic inflammation within the outer aortic wall, and an imbalance between the production and degradation of structural extracellular matrix proteins (White et al, 1993).…”

mentioning

confidence: 99%

A Specific Chymase Inhibitor, 2-(5-Formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide (NK3201), Suppresses Development of Abdominal Aortic Aneurysm in Hamsters

Tsunemi

Takai²,

Nishimoto³

et al. 2004

J Pharmacol Exp Ther

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In this study, we investigated the effect of a specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide (NK3201), in the development of abdominal aortic aneurysm in a hamster experimental model. The abdominal aortic aneurysm was induced by application of elastase onto the abdominal aorta in hamster. Each hamster was administered NK3201 (30 mg/kg/day p.o.) or placebo beginning 4 days before application of elastase and continuing through the experiments. Sham-operated hamsters received saline application onto the abdominal aorta. Two weeks after application of elastase, the aortic diameter in the placebo-treated group was significantly increased to 1.6-fold compared with the value for the sham-operated group, whereas that in the NK3201-treated group was significantly reduced. The chymase activities in the sham-operated and the placebo-treated groups were 0.35 Ϯ 0.01 and 3.44 Ϯ 0.62 mU/mg protein, respectively, and this difference was significant. NK3201 significantly reduced the chymase activity in the placebo-treated group. Here, we demonstrated for the first time that a chymase inhibitor prevented the development of abdominal aortic aneurysm in a hamster experimental model.

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“…Elevation of blood pressure is one of the causes for rapid expansion, but blood pressure was normally controlled and intentional hypertension was not induced to treat vasospasm in our case. 10) Intramural hemorrhage, which may be another factor causing acute enlargement of abdominal aortic aneurysm, was not present in our case. 1) The risk of rupture of incidental abdominal aortic aneurysm is dependent on its size.…”

Section: H Kanai Et Almentioning

confidence: 45%

Ruptured Intracranial Aneurysm Associated With Unruptured Abdominal Aortic Aneurysm. Case Report.

Kanai

Umezu

Koide

et al. 2001

Neurol. Med. Chir.(Tokyo)

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A 61-year-old male with hypertension presented with sudden onset of headache and nausea due to subarachnoid hemorrhage (SAH). He had two siblings with history of SAH due to ruptured intracranial aneurysms. Right carotid angiography on admission showed an anterior communicating artery aneurysm. At that time, the extracranial arteries were not examined. The aneurysm was clipped with no complications. A pulsating mass was palpable in the abdomen 37 days after the onset. Ultrasonography and computed tomography showed an abdominal aortic aneurysm with intraluminal thrombus, measuring 8 × 9 × 8 cm. Normal pressure hydrocephalus had already developed. The patient underwent elective abdominal aortic aneurysm resection before ventriculoperitoneal shunting. After shunting, he recovered fully. The present case indicates that unpredictable sudden enlargement of associated abdominal aortic aneurysm is possible in patients with ruptured intracranial aneurysms.

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Factors influencing enlargement rate of small abdominal aortic aneurysms

Cited by 127 publications

References 5 publications

Possible Roles of Angiotensin II-Forming Enzymes, Angiotensin Converting Enzyme and Chymase-like Enzyme, in the Human Aneurysmal Aorta.

Possible Roles of Angiotensin II-Forming Enzymes, Angiotensin Converting Enzyme and Chymase-like Enzyme, in the Human Aneurysmal Aorta.

A Specific Chymase Inhibitor, 2-(5-Formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[{3,4-dioxo-1-phenyl-7-(2-pyridyloxy)}-2-heptyl]acetamide (NK3201), Suppresses Development of Abdominal Aortic Aneurysm in Hamsters

Ruptured Intracranial Aneurysm Associated With Unruptured Abdominal Aortic Aneurysm. Case Report.

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