Factors influencing drug and protein transport and release from ionic hydrogels

Ende, Mary T. am; Hariharan, D.; Peppas, Nicholas A.

doi:10.1016/0923-1137(94)00040-c

Cited by 170 publications

(114 citation statements)

References 18 publications

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“…They also are found to be valuable in artificial snow, 1,2 agriculture, [3][4][5] horticulture, 3,6 drilling fluid additives, 7 polymer concrete suited for use in repairing cracks, 8 dewpreventing coating, 9 fighting fire, 10 sealing composite in long distance cable, 11,12 and drug delivery. 13,14 Aqueous solution polymerization can be used to prepare superabsorbents. However, relatively low monomer concentration was used in the recent reports.…”

Section: Inroductionmentioning

confidence: 99%

An efficient preparation method for superabsorbent polymers

Chen

Yao-ming

1999

J. Appl. Polym. Sci.

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High water-absorbent polyacrylates could be prepared by concentrated aqueous solution polymerization within a short time period, heating the monomer mixture by water bath. The influences of initiator content, bath temperature, crosslinker content (Cc), and degree of neutralization on water absorbency (Q) were investigated. The temperature changing of the monomer mixture during polymerization was thoroughly analyzed. The increase of initiator content as well as the increase of bath temperature results in the increase of water absorbency and reduces the crosslinking efficiency. The results are in conformity with Flory's network theory and also illustrate that lower crosslinking efficiency occurs when the polymerization rate is faster. An empirical relation of Q ϭ 1.40 Cc Ϫ0.665 is obtained and its exponent is very close to Ϫ0.6 in a derived relation.

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Section: Inroductionmentioning

confidence: 99%

An efficient preparation method for superabsorbent polymers

Chen

Yao-ming

1999

J. Appl. Polym. Sci.

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“…Therefore, superabsorbents have great advantages over traditional water-absorbing materials such as cotton, pulp, and sponge, and have found a variety of valuable applications. [1][2][3] Because of their excellent characteristics, these superabsorbents are widely used in many fields such as agriculture and horticulture, 4,5 sanitary goods, 6 sealing composites, 7 and medicine for drug-delivery systems, 8 for example. The synthesis of new superabsorbents and the development of their applications are still interesting research areas.…”

Section: Introductionmentioning

confidence: 99%

Studies on poly(acrylic acid)/attapulgite superabsorbent composite. I. Synthesis and characterization

Liu¹,

Wang²,

Chen³

2004

J of Applied Polymer Sci

268

156

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A novel poly(acrylic acid)/attapulgite superabsorbent composite was synthesized by graft copolymerization reaction of acrylic acid (AA) on attapulgite micropowder using N,NЈ-methylenebisacrylamide (MBA) as a crosslinker and ammonium persulfate (APS) as an initiator in aqueous solution. The effects on water absorbency of such factors as reaction temperature, initial monomer concentration, degree of neutralization of AA, amount of crosslinker, initiator, and attapulgite were investigated. These crosslinked superabsorbent composites were characterized by thermogravimetetric analysis and scanning electron microscopy. The graft copolymerization reaction of AA on attapulgite micropowder was characterized by FTIR. The water absorbencies for these superabsorbent composites in water and saline solutions were investigated and water-retention tests were carried out. Results obtained from this study show that the water absorbency of the superabsorbent composite synthesized under optimal synthesis conditions with an attapulgite content of 10% exhibited an absorption of 1017 g H 2 O/g sample and 77 g H 2 O/g sample in distilled water and in 0.9 wt % NaCl solution, respectively.

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“…They are also found to be valuable in artificial snow, 1,2 agriculture, [3][4][5] horticulture, 3,6 drilling fluid additives, 7 polymer concrete suited for use in repairing cracks, 8 dew-preventing coatings, 9 fire fighting, 10 sealing composites in long distance cable, 11,12 and drug delivery. 13,14 In our previous studies, 15,16 polyacrylate superabsorbents were prepared by concentrated aqueous solution polymerization in a stainlesssteel dish, which was heated by hot air in a thermostatic oven 15 or heated from one side by a water bath. 16 Polymeric gel was formed at the end of the polymerization.…”

Section: Introductionmentioning

confidence: 99%

Relationship between water absorbency and reaction conditions in aqueous solution polymerization of polyacrylate superabsorbents

Chen

Yao-ming

2000

J. Appl. Polym. Sci.

159

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Polyacrylate superabsorbents were prepared by in situ aqueous solution polymerization in a polyethylene bag, which was submerged in a water bath. The influence of the initiator content, bath temperature, isopropanol content, initial monomer concentration, and crosslinker content (Cc) on water absorbency (Q) were investigated. The temperature change of the monomer mixture during polymerization was also analyzed. Increase of the chain ends in networks resulting from decrease of the molecular weight in free-radical polymerization causes an increase of the water absorbency of superabsorbents and also reduces the crosslinking efficiency. The results are in conformity with the classical network theory. An empirical relation of Q ϭ 2.45 Cc Ϫ0.600 was obtained and the validity of Flory's swelling equation was confirmed indirectly.

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Factors influencing drug and protein transport and release from ionic hydrogels

Cited by 170 publications

References 18 publications

An efficient preparation method for superabsorbent polymers

An efficient preparation method for superabsorbent polymers

Studies on poly(acrylic acid)/attapulgite superabsorbent composite. I. Synthesis and characterization

Relationship between water absorbency and reaction conditions in aqueous solution polymerization of polyacrylate superabsorbents

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