Factors Influencing Drug Absorption and Drug Availability

Development of formulations that enhance physical stability of viral vectors for gene therapy

“…Some excipients can enhance drug absorption. 19 As a result, less medicine is needed to exert the desired effect. Some excipients, however, have been implicated as causing, contributing to, or playing some role in certain human reactions not related to the active compound.…”

Technologies, Optimization and Analytical Parameters in Gastroretentive Drug Delivery Systems

“…volume, viscosity and caloric amount is important; therefore a high-fat meal will strongly increase the GRT. Other delayed gastric emptying approaches of interest include indigestible polymers or fatty acid salts that change the motility pattern of the stomach to a fed state, in that way falling the gastric emptying rate in addition to allowing substantial continuation of drugs release 23,24 . The frequency of food intake will also significantly increase the GRT.…”

High-amylose carboxymethyl starch matrices for oral sustained drug-release: In vitro and in vivo evaluation

“…Consequently, the tablet disintegrates into granules or aggregates of primary particles, which subsequently deaggregate into their primarily drug particles. A deaggregation directly into fine particles will set up conditions for the fastest dissolution of the drug (Leblanc, Aiache et al 1997;Alderborn 2002;Hoener and Benet 2002). However, drug dissolution can start before the complete fragmentation of the tablet.…”

“…After the drug is in solution in the gastrointestinal tract, absorption may take place. The rate-limiting step in the dissolution process can be either the rate of disintegration of the dosage form and the size of the resulting aggregates or the deaggregation process (Hoener and Benet 2002). A disintegrant is usually included in the formulation of IR tablets to ensure that the tablet, when in contact with a liquid, breaks up into small fragments, promoting rapid drug dissolution.…”