Factors governing prepulse inhibition and prepulse facilitation of the acoustic startle response in mice

Plappert, Claudia F.; Pilz, P.; Schnitzler, Hans‐Ulrich

doi:10.1016/j.bbr.2003.10.025

Cited by 69 publications

(109 citation statements)

References 36 publications

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“…These results show that for the full interpretation of drug effects on PPI, an extended protocol, including multiple prepulse intensities and ISIs, is preferable. Particularly at the shorter ISIs, modulation of the startle responses is a mix of true PPI and of negative PPI or prepulse facilitation (PPF) (Plappert et al, 2004;Swerdlow et al, 2004a,b). The regulation and functional significance of PPF is poorly understood.…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Antipsychotic Drugs on Serotonin-1A Receptor-Mediated Disruption of Prepulse Inhibition

Buuse¹,

Gogos²

2006

J Pharmacol Exp Ther

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Serotonin-1A (5-HT 1A ) receptors have been implicated in the symptoms of schizophrenia. However, there is limited in vivo evidence for an interaction of antipsychotic drugs with 5-HT 1A receptor-mediated behavioral effects. We therefore investigated in rats the action of several antipsychotic drugs on prepulse inhibition (PPI), a measure of sensorimotor gating that is deficient in schizophrenia. Disruption of PPI at the 100-ms interstimulus interval (ISI), but not the 30-ms ISI, was induced by treatment with 0.5 mg/kg 8-hydroxy-di-propylaminotetralin

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Section: Discussionmentioning

confidence: 99%

Differential Effects of Antipsychotic Drugs on Serotonin-1A Receptor-Mediated Disruption of Prepulse Inhibition

Buuse¹,

Gogos²

2006

J Pharmacol Exp Ther

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“…Random intertrial intervals (15-30 s) were used between all trials. These conditions were selected based on the reported optimal conditions for measuring PPI in C57BL/6 mice (Plappert et al, 2004). For each individual mouse, the baseline response was used as correction by subtracting an average of six no-stimulation responses, three after the initial acclimation period and three after the test phase in the second series.…”

Section: Prepulse Inhibitionmentioning

confidence: 99%

“…PPI was assessed by comparing the startle response to the acoustic stimuli following prepulse to the initial response using the following formula: % response ¼ 100 Â ((SÀPS)/S)), where S is the mean startle amplitude without prepulses and PS is the mean startle response following the prepulse condition. Response (100%) means that there was no effect of prepulse on the startle response (Plappert et al, 2004).…”

Section: Prepulse Inhibitionmentioning

confidence: 99%

“…For assessments of PPI, each mouse was tested in one session consisting of two series of acoustic stimuli followed by a testing phase. All conditions were selected based on the reported optimal conditions for measuring PPI in C57BL/6 mice (Plappert et al, 2004). Compared to SA-treated mice, there was a reduction in PPI following a postpulse of 120 db in MAtreated female mice and following a postpulse of 110 or 120 db in MA-treated male mice.…”

Section: Prepulse Inhibitionmentioning

confidence: 99%

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Sex- and Histamine-Dependent Long-Term Cognitive Effects of Methamphetamine Exposure

Acevedo

Esch

Raber

2006

Neuropsychopharmacol

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As prenatal methamphetamine (MA) exposure results in long-term hippocampus-dependent cognitive deficits, the increased MA use in women of childbearing age is of great concern. As mice are most commonly used in genetic models, we started to study the potential effects of neonatal MA exposure in female and male mice on brain function 3 months later. As histamine (HA) might mediate some effects of MA in adulthood, we also tested whether in neonates HA might mediate the long-term effects of MA using HA H 3 receptor agonists and antagonists. Stimulation of HA H 3 receptors by H 3 agonists inhibits HA synthesis and release, whereas inhibition of H 3 receptors by H 3 receptor antagonists increases HA release. MA (5 mg/kg), the H 3 receptor antagonist thioperamide (5 mg/kg), and the H 3 receptor agonist immepip (5 mg/kg) alone or in the presence of MA (5 mg/kg) were administered once daily from postnatal days 11 to 20 and the mice were tested at 3 months of age. Here we show that in mice exposure to MA early in life causes sex-dependent impairments in object recognition, spatial learning, and memory in the water maze, and pre-pulse inhibition in adulthood. HA mediates these impairments. Increasing HA release mimicked, whereas inhibiting HA release blocked the long-term detrimental MA effects. This model could be used to determine the role of genetic and environmental factors in MA-dependent cognitive impairments and to develop therapeutic strategies to inhibit them. Neuropsychopharmacology (2007) 32, 665-672.

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“…There is a critical time interval, called the lead time interval T or the interstimulus interval, between 20 and 800 ms in rodents (Hoffman and Ison 1980;Yeomans et al 2006;Plappert et al 2004) or between 45 and 2,020 ms in monkeys (Winslow et al 2002), between the prepulse onset and the pulse onset, relation (8), which comes from the transmission time difference between PPI pathway and ASR pathway, converging at the NRPC. The strongest inhibition of ASR occurs when the prepulse, with 10-30-ms duration, precedes the startle stimulus by the lead interval (Swerdlow 1992).…”

Section: Model Neural Network For Acoustic Startle Reflex and Prepulsmentioning

confidence: 99%

A computational model for the modulation of the prepulse inhibition of the acoustic startle reflex

Ramirez-Moreno

Sejnowski

2012

Biol Cybern

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The acoustic startle reflex (ASR), a defensive response, is a contraction of the skeletal and facial muscles in response to an abrupt, intense (>80 db) auditory stimulus, which has been extensively studied in rats and humans. Prepulse inhibition (PPI) of ASR is the normal suppression of the startle reflex when an intense stimulus is preceded by a weak non-starting pre-stimulus. PPI, a measure of sensory motor gating, is impaired in various neuropsychiatric disorders, including schizophrenia, and is modulated by cognitive and emotional contexts such as fear and attention. We have modeled the fear modulation of PPI of ASR based on its anatomical substrates and taking into account data from behaving rats and humans. The model replicates the principal features of both phenomena and predicts underlying neural mechanisms. In addition, the model yields testable predictions.

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Factors governing prepulse inhibition and prepulse facilitation of the acoustic startle response in mice

Cited by 69 publications

References 36 publications

Differential Effects of Antipsychotic Drugs on Serotonin-1A Receptor-Mediated Disruption of Prepulse Inhibition

Differential Effects of Antipsychotic Drugs on Serotonin-1A Receptor-Mediated Disruption of Prepulse Inhibition

Sex- and Histamine-Dependent Long-Term Cognitive Effects of Methamphetamine Exposure

A computational model for the modulation of the prepulse inhibition of the acoustic startle reflex

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