2005
DOI: 10.1007/s00280-005-0024-5 View full text |Buy / Rent full text
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Abstract: There are potential advantages to detecting pharmacodynamic (PD) and pharmacokinetic (PK) endpoints in a tissue-based compartment such as the skin during the development of molecularly targeted drugs. We explored regional differences between inner arm, inner thigh, lower back and buttocks in 12 healthy male Caucasian volunteers in the tolerability of skin biopsy procedures; the Ki67 proliferation index; the frequency of detecting hair follicles and sweat glands; and the percentage of melanocytes. We also explo… Show more

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“…24, 35 Normal proliferative indices (PI; stained cells:total cells) vary based on numerous factors including the anatomical location of the skin and the age of the individual. 36, 37 The data shown here indicate that the PI values for StrataGraft skin substitute are more uniform than those for cryopreserved cadaver allograft. These data suggest that StrataGraft is a more consistent source of viable keratinocytes which will respond reliably within the context of a wound bed.…”
Section: Discussionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…24, 35 Normal proliferative indices (PI; stained cells:total cells) vary based on numerous factors including the anatomical location of the skin and the age of the individual. 36, 37 The data shown here indicate that the PI values for StrataGraft skin substitute are more uniform than those for cryopreserved cadaver allograft. These data suggest that StrataGraft is a more consistent source of viable keratinocytes which will respond reliably within the context of a wound bed.…”
Section: Discussionmentioning
“…Several studies were performed in order to evaluate the optimal body site for skin biopsies and to assess PD and PK end points [89] , or to assess the feasibility of detecting signals for a range of different immunohistochemistry markers within the buccal mucosa [90] and plucked human hair [91] .…”
Section: Surrogate Tissuesmentioning