Factors determining direct arterial pressure and its variability in hypertensive man.

Watson, R. Douglas; Stallard, T. J.; Flinn, R. M.; Littler, W. A.

doi:10.1161/01.hyp.2.3.333

Cited by 137 publications

(49 citation statements)

References 46 publications

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“…33 This was the case also when the baroreceptor reflex sensitivity was estimated by the blood pressure response to the alteration in carotid baroreceptor activity induced by a neck chamber. 33 Most important, the inverse relation between baroreceptor reflex sensitivity and blood pressure variability, a finding confirmed by other studies, 34 " 36 was also found within individual subjects in whom hourly blood pressure variability was plotted versus hourly baroreceptor reflex sensitivity estimated by computer analysis of the beat-to-beat relation of the systolic blood pressure and pulse interval values (see below) ( Figure 8). It is thus clear that, in line with classic animal data, the arterial baroreceptor reflex limits the blood pressure variations occurring in humans partly via opposite changes in heart rate and cardiac output. "…”

Section: Average Use) Powers Normalized Over Total Variancesupporting

confidence: 75%

Ambulatory blood pressure monitoring use in hypertension research and clinical practice.

1993

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Section: Average Use) Powers Normalized Over Total Variancesupporting

confidence: 75%

Ambulatory blood pressure monitoring use in hypertension research and clinical practice.

1993

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“…40,41 Apart from increased left ventricular mass in Africans, Li et al 44 indicated recently that African Americans have higher BP variability than European Americans, contradicting a small study performed in England (N¼26) that indicated no ethnic differences. 45 Li et al 44 argue that the higher BP variability values of Africans are consistent with the prognostic value of BP variability, and the higher incidence and mortality of cardiovascular disease in Africans. Our study indicates contrasting results.…”

Section: Discussionmentioning

confidence: 91%

Blood pressure variability is significantly associated with ECG left ventricular mass in normotensive Africans: The SABPA Study

Schutte

Huisman

et al. 2011

Hypertens Res

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The prognostic significance of blood pressure (BP) variability has lately enjoyed considerable attention. The need for early markers of cardiovascular dysfunction is imperative in black South Africans who have a significant risk for cardiovascular disease. We therefore compared 24-h BP variability with various traditional and advanced BP measurements, regarding their association with sub-clinical organ damage in black and white South Africans. The study included 409 African and Caucasian teachers aged 25-60 yrs. We measured office BP, 1-min continuous (finger) BP, ambulatory BP, BP reactivity and determined weighted 24-h BP variability. Albumin-to-creatinine ratio, Cornell product and carotid cross-sectional wall area (CSWA) were measures of organ damage. Africans had higher 24-h BP, BP variability, BP reactivity and sub-clinical organ damage (Po0.001). Correlations of BP variability with organ damage were overall weak when compared with other BP measurements. In normotensive groups, we found an independent association of 24-h systolic BP (SBP) variability with Cornell product only in Africans (r¼0.37; P¼0.01), confirmed in multiple regression models, with 24-h SBP included in the model. Only in hypertensive Caucasians, a significant correlation between CSWA and 24-h SBP variability was evident (r¼0.30; P¼0.01), although CSWA indicated stronger correlations with office or 24-h SBP than 24-h SBP variability. To conclude, 24-h SBP variability could potentially be an effective measure for the early detection of normotensive Africans at increased risk for the development of cardiovascular complications. Its usefulness based on associations with target organ damage in hypertensive groups seems to be less than traditional office or 24-h BP measurements. Hypertension Research (2011Research ( ) 34, 1127Research ( -1134 doi:10.1038/hr.2011; published online 28 July 2011Keywords: albumin-to-creatinine ratio; ethnicity; intima-media thickness; left ventricular hypertrophy INTRODUCTIONThe prognostic significance of blood pressure (BP) variability has lately enjoyed considerable attention in the literature. [1][2][3][4][5][6][7][8][9][10] Where some papers emphasize the importance of BP variability in prediction of risk of vascular events, 1,2,6,9 others question its prediction of cardiovascular outcome. 4,5,10 Despite this upsurge of recent papers, consistent evidence over the past three decades lends support that both target organ damage and the rate of cardiovascular events of hypertensive patients are significantly and independently related to the degree of BP variability. [11][12][13][14][15] A limitation of many of these papers is that either BP variability alone was investigated, or various measures of BP variability (such as s.d. of 24-h BP, average real variability index 16 and weighted 24-h BP s.d. 17 ) were being compared, regarding the strength of their association with target organ damage.The question therefore arises how BP variability would benchmark against a comprehensive range of both traditional and advanced

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“…Cardiovagal baroreflex sensitivity has been related to blood pressure (negatively) and HRV (positively), primarily in patients with essential hypertension. 16,26 However, correlations were modest at best, explaining only 25% or less of the inter-individual variance, and were related in part to baseline blood pressure. 16 The absence of significant correlations in the present study may be attributed in part to the fact that our subjects were normotensive and/or that cardiovascular variability was measured over a short duration, whereas previous associations were established with 24-hour recordings.…”

Section: Discussionmentioning

confidence: 97%

Baroreflex Buffering Is Reduced With Age in Healthy Men

et al. 2003

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Factors determining direct arterial pressure and its variability in hypertensive man.

Cited by 137 publications

References 46 publications

Ambulatory blood pressure monitoring use in hypertension research and clinical practice.

Ambulatory blood pressure monitoring use in hypertension research and clinical practice.

Blood pressure variability is significantly associated with ECG left ventricular mass in normotensive Africans: The SABPA Study

Baroreflex Buffering Is Reduced With Age in Healthy Men

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